Morris F White

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1986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025245 314 463 625 584 697 876 1184 1552 1700 1829 2058 2254 2078 2003 2325 2360 2156 2509 2859 2637 2877 2868 2908 2804 2831 3083 3006 3019 2744 2652 2388 2396 2093 2104 2261 1978 1870 1615 266

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C. Ronald KahnJoslin Diabetes Center and Harvard Medical SchoolVerifisert e-postadresse på joslin.harvard.edu
Martin MyersUniversity of MichiganVerifisert e-postadresse på umich.edu
Xiao Jian SunThe University of MarylandVerifisert e-postadresse på medicine.umaryland.edu
Lynne YenushProfesor Departamento de Biotecnología Universidad Politécnica de ValenciaVerifisert e-postadresse på ibmcp.upv.es
Steven ShoelsonHarvard Medical SchoolVerifisert e-postadresse på joslin.harvard.edu
Gerald I ShulmanYale School of Medicine/Howard Hughes Medical InstituteVerifisert e-postadresse på yale.edu
Sebastian PonsInstituto de Biología Molecular de BarcelonaVerifisert e-postadresse på ibmb.csic.es
Zhiyong ChengUniversity of FloridaVerifisert e-postadresse på ufl.edu
Shaodong GuoTexas A&M University, College Station, Texas USAVerifisert e-postadresse på tamu.edu
Barry J. GoldsteinVice President and Therapeutic Area Head, Covance, IncVerifisert e-postadresse på covance.com
Bruce M. SpiegelmanStanley J. Korsmeyer Professor, Harvard Medical School and Dana-Farber Cancer InstituteVerifisert e-postadresse på dfci.harvard.edu
Hans-Ulrich HäringProfessor of Endocrinology and DiabetologyVerifisert e-postadresse på med.uni-tuebingen.de
Liangyou RuiLouis G. D'Alecy Collegiate Professor of Physiology, University of Michigan Medical SchoolVerifisert e-postadresse på umich.edu
Marianna SadagurskiWayne State UniversityVerifisert e-postadresse på wayne.edu
X. Charlie DongIndiana University School of MedicineVerifisert e-postadresse på iu.edu
John BlenisProfessor of Pharmacology, Weill Cornell MedicineVerifisert e-postadresse på med.cornell.edu
Stephen PrevisMerckVerifisert e-postadresse på merck.com
Joseph SchlessingerYale university School of MedicineVerifisert e-postadresse på Yale.edu
Susan Bonner-Weir , Susan Bonner W...Joslin Diabetes Center, Harvard Medical SchoolVerifisert e-postadresse på joslin.harvard.edu
Sunmin ParkHoseo UniversityVerifisert e-postadresse på hoseo.edu

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Morris F White

Professor of Pediatrics, Harvard Medical School

Verifisert e-postadresse på childrens.harvard.edu - Startside

insulin action insulin diabetes


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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α-and obesity-induced insulin resistance GS Hotamisligil, P Peraldi, A Budavari, R Ellis, MF White, BM Spiegelman Science 271 (5249), 665-670, 1996	3735	1996
Disruption of IRS-2 causes type 2 diabetes in mice DJ Withers, JS Gutierrez, H Towery, DJ Burks, JM Ren, S Previs, Y Zhang, ... Nature 391 (6670), 900-904, 1998	2152	1998
The insulin signaling system. MF White, CR Kahn Journal of Biological Chemistry 269 (1), 1-4, 1994	2110	1994
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein XJ Sun, P Rothenberg, CR Kahn, JM Backer, E Araki, PA Wilden, ... Nature 352 (6330), 73-77, 1991	2065	1991
The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307 V Aguirre, T Uchida, L Yenush, R Davis, MF White Journal of Biological Chemistry 275 (12), 9047-9054, 2000	1988	2000
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle C Yu, Y Chen, GW Cline, D Zhang, H Zong, Y Wang, R Bergeron, JK Kim, ... Journal of Biological Chemistry 277 (52), 50230-50236, 2002	1973	2002
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. ME Griffin, MJ Marcucci, GW Cline, K Bell, N Barucci, D Lee, LJ Goodyear, ... Diabetes 48 (6), 1270-1274, 1999	1733	1999
IRS proteins and the common path to diabetes MF White American Journal of Physiology-Endocrinology and Metabolism 283 (3), E413-E422, 2002	1335	2002
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action V Aguirre, ED Werner, J Giraud, YH Lee, SE Shoelson, MF White Journal of biological chemistry 277 (2), 1531-1537, 2002	1302	2002
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2 L Rui, M Yuan, D Frantz, S Shoelson, MF White Journal of Biological Chemistry 277 (44), 42394-42398, 2002	1206	2002
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 KD Copps, MF White Diabetologia 55, 2565-2582, 2012	1181	2012
Role of IRS-2 in insulin and cytokine signalling XJ Sun, LM Wang, Y Zhang, L Yenush, MG Myers Jr, E Glasheen, ... Nature 377 (6545), 173-177, 1995	1174	1995
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents K Morino, KF Petersen, S Dufour, D Befroy, J Frattini, N Shatzkes, ... The Journal of clinical investigation 115 (12), 3587-3593, 2005	1047	2005
The IRS-signalling system: a network of docking proteins that mediate insulin action MF White Insulin Action, 3-11, 1998	1013	1998
Insulin signaling in health and disease MF White Science 302 (5651), 1710-1711, 2003	958	2003
Insulin rapidly stimulates tyrosine phosphorylation of a M_r-185,000 protein in intact cells MF White, R Maron, CR Kahn Nature 318 (6042), 183-186, 1985	880	1985
The SH2/SH3 domain‐containing protein GRB2 interacts with tyrosine‐phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EY Skolnik, CH Lee, A Batzer, LM Vicentini, M Zhou, R Daly, MJ Myers Jr, ... The EMBO journal 12 (5), 1929-1936, 1993	874	1993
The insulin signalling system and the IRS proteins MF White Diabetologia 40, S2-S17, 1997	803	1997
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats ZY Jiang, YW Lin, A Clemont, EP Feener, KD Hein, M Igarashi, ... The Journal of clinical investigation 104 (4), 447-457, 1999	795	1999
Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser³⁰⁷ via distinct pathways L Rui, V Aguirre, JK Kim, GI Shulman, A Lee, A Corbould, A Dunaif, ... The Journal of clinical investigation 107 (2), 181-189, 2001	794	2001

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