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Peter J. Chen
Peter J. Chen
Prime Medicine
Zweryfikowany adres z primemedicine.com
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Search-and-replace genome editing without double-strand breaks or donor DNA
AV Anzalone, PB Randolph, JR Davis, AA Sousa, LW Koblan, JM Levy, ...
Nature 576 (7785), 149-157, 2019
41602019
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes
PJ Chen, JA Hussmann, J Yan, F Knipping, P Ravisankar, PF Chen, ...
Cell 184 (22), 5635-5652. e29, 2021
5752021
Engineered pegRNAs improve prime editing efficiency
JW Nelson, PB Randolph, SP Shen, KA Everette, PJ Chen, AV Anzalone, ...
Nature biotechnology 40 (3), 402-410, 2022
5212022
Prime editing for precise and highly versatile genome manipulation
PJ Chen, DR Liu
Nature Reviews Genetics 24 (3), 161-177, 2023
3062023
Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase
C Wilson, PJ Chen, Z Miao, DR Liu
Nature biotechnology 38 (12), 1431-1440, 2020
2542020
Efficient prime editing in mouse brain, liver and heart with dual AAVs
JR Davis, S Banskota, JM Levy, GA Newby, X Wang, AV Anzalone, ...
Nature biotechnology 42 (2), 253-264, 2024
1102024
In vivo HSC prime editing rescues sickle cell disease in a mouse model
C Li, A Georgakopoulou, GA Newby, PJ Chen, KA Everette, K Paschoudi, ...
Blood, The Journal of the American Society of Hematology 141 (17), 2085-2099, 2023
882023
Designing and executing prime editing experiments in mammalian cells
JL Doman, AA Sousa, PB Randolph, PJ Chen, DR Liu
Nature protocols 17 (11), 2431-2468, 2022
812022
Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice
KA Everette, GA Newby, RM Levine, K Mayberry, Y Jang, T Mayuranathan, ...
Nature Biomedical Engineering 7 (5), 616-628, 2023
782023
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus
Q Ji, PJ Chen, G Qin, X Deng, Z Hao, Z Wawrzak, WS Yeo, JW Quang, ...
Nature communications 7 (1), 11000, 2016
392016
Continuous evolution of compact protein degradation tags regulated by selective molecular glues
JAM Mercer, SJ DeCarlo, SS Roy Burman, V Sreekanth, AT Nelson, ...
Science 383 (6688), eadk4422, 2024
192024
Rna programmable epigenetic rna modifiers and uses thereof
DR Liu, CG Wilson, PJ Chen
US Patent App. 17/259,147, 2022
182022
Efficient prime editing in two-cell mouse embryos using PEmbryo
RP Kim-Yip, R McNulty, B Joyce, A Mollica, PJ Chen, P Ravisankar, ...
Nature biotechnology 42 (12), 1822-1830, 2024
72024
Author Correction: Engineered pegRNAs improve prime editing efficiency
JW Nelson, PB Randolph, SP Shen, KA Everette, PJ Chen, AV Anzalone, ...
Nature biotechnology 40 (3), 432, 2022
42022
Prime editing guide rnas, compositions thereof, and methods of using the same
DR Liu, JW Nelson, PB Randolph, AV Anzalone, S Shen, K Everette, ...
US Patent App. 18/028,183, 2023
32023
METHODS AND COMPOSITIONS FOR PRIME EDITING RNA
DR Liu, AV Anzalone, JW Nelson, PJ Chen
US Patent App. 17/767,777, 2024
2024
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