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Enhanced prime editing systems by manipulating cellular determinants of editing outcomes PJ Chen, JA Hussmann, J Yan, F Knipping, P Ravisankar, PF Chen, ... Cell 184 (22), 5635-5652. e29, 2021 | 575 | 2021 |
Engineered pegRNAs improve prime editing efficiency JW Nelson, PB Randolph, SP Shen, KA Everette, PJ Chen, AV Anzalone, ... Nature biotechnology 40 (3), 402-410, 2022 | 521 | 2022 |
Prime editing for precise and highly versatile genome manipulation PJ Chen, DR Liu Nature Reviews Genetics 24 (3), 161-177, 2023 | 306 | 2023 |
Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase C Wilson, PJ Chen, Z Miao, DR Liu Nature biotechnology 38 (12), 1431-1440, 2020 | 254 | 2020 |
Efficient prime editing in mouse brain, liver and heart with dual AAVs JR Davis, S Banskota, JM Levy, GA Newby, X Wang, AV Anzalone, ... Nature biotechnology 42 (2), 253-264, 2024 | 110 | 2024 |
In vivo HSC prime editing rescues sickle cell disease in a mouse model C Li, A Georgakopoulou, GA Newby, PJ Chen, KA Everette, K Paschoudi, ... Blood, The Journal of the American Society of Hematology 141 (17), 2085-2099, 2023 | 88 | 2023 |
Designing and executing prime editing experiments in mammalian cells JL Doman, AA Sousa, PB Randolph, PJ Chen, DR Liu Nature protocols 17 (11), 2431-2468, 2022 | 81 | 2022 |
Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice KA Everette, GA Newby, RM Levine, K Mayberry, Y Jang, T Mayuranathan, ... Nature Biomedical Engineering 7 (5), 616-628, 2023 | 78 | 2023 |
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus Q Ji, PJ Chen, G Qin, X Deng, Z Hao, Z Wawrzak, WS Yeo, JW Quang, ... Nature communications 7 (1), 11000, 2016 | 39 | 2016 |
Continuous evolution of compact protein degradation tags regulated by selective molecular glues JAM Mercer, SJ DeCarlo, SS Roy Burman, V Sreekanth, AT Nelson, ... Science 383 (6688), eadk4422, 2024 | 19 | 2024 |
Rna programmable epigenetic rna modifiers and uses thereof DR Liu, CG Wilson, PJ Chen US Patent App. 17/259,147, 2022 | 18 | 2022 |
Efficient prime editing in two-cell mouse embryos using PEmbryo RP Kim-Yip, R McNulty, B Joyce, A Mollica, PJ Chen, P Ravisankar, ... Nature biotechnology 42 (12), 1822-1830, 2024 | 7 | 2024 |
Author Correction: Engineered pegRNAs improve prime editing efficiency JW Nelson, PB Randolph, SP Shen, KA Everette, PJ Chen, AV Anzalone, ... Nature biotechnology 40 (3), 432, 2022 | 4 | 2022 |
Prime editing guide rnas, compositions thereof, and methods of using the same DR Liu, JW Nelson, PB Randolph, AV Anzalone, S Shen, K Everette, ... US Patent App. 18/028,183, 2023 | 3 | 2023 |
METHODS AND COMPOSITIONS FOR PRIME EDITING RNA DR Liu, AV Anzalone, JW Nelson, PJ Chen US Patent App. 17/767,777, 2024 | | 2024 |