Obg and membrane depolarization are part of a microbial bet-hedging strategy that leads to antibiotic tolerance N Verstraeten, WJ Knapen, CI Kint, V Liebens, B Van den Bergh, ... Molecular cell 59 (1), 9-21, 2015 | 338 | 2015 |
Bacterial heterogeneity and antibiotic survival: understanding and combatting persistence and heteroresistance L Dewachter, M Fauvart, J Michiels Molecular cell 76 (2), 255-267, 2019 | 197 | 2019 |
The persistence-inducing toxin HokB forms dynamic pores that cause ATP leakage D Wilmaerts, M Bayoumi, L Dewachter, W Knapen, JT Mika, J Hofkens, ... MBio 9 (4), 10.1128/mbio. 00744-18, 2018 | 87 | 2018 |
An integrative view of cell cycle control in Escherichia coli L Dewachter, N Verstraeten, M Fauvart, J Michiels FEMS Microbiology Reviews 42 (2), 116-136, 2018 | 86 | 2018 |
HokB monomerization and membrane repolarization control persister awakening D Wilmaerts, L Dewachter, PJ De Loose, C Bollen, N Verstraeten, ... Molecular cell 75 (5), 1031-1042. e4, 2019 | 74 | 2019 |
The dynamic transition of persistence toward the viable but nonculturable state during stationary phase is driven by protein aggregation L Dewachter, C Bollen, D Wilmaerts, E Louwagie, P Herpels, P Matthay, ... MBio 12 (4), 10.1128/mbio. 00703-21, 2021 | 66 | 2021 |
Protein aggregation as a bacterial strategy to survive antibiotic treatment C Bollen, L Dewachter, J Michiels Frontiers in molecular biosciences 8, 669664, 2021 | 58 | 2021 |
Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis B Van den Bergh, H Schramke, JE Michiels, TEP Kimkes, JL Radzikowski, ... Nature communications 13 (1), 546, 2022 | 37 | 2022 |
Deep mutational scanning of essential bacterial proteins can guide antibiotic development L Dewachter, AN Brooks, K Noon, C Cialek, A Clark-ElSayed, T Schalck, ... nature communications 14 (1), 241, 2023 | 29 | 2023 |
A single-amino-acid substitution in Obg activates a new programmed cell death pathway in Escherichia coli L Dewachter, N Verstraeten, D Monteyne, CI Kint, W Versées, ... MBio 6 (6), 10.1128/mbio. 01935-15, 2015 | 28 | 2015 |
A mutant isoform of ObgE causes cell death by interfering with cell division L Dewachter, N Verstraeten, M Jennes, T Verbeelen, J Biboy, D Monteyne, ... Frontiers in microbiology 8, 1193, 2017 | 21 | 2017 |
Reactive oxygen species do not contribute to ObgE*-mediated programmed cell death L Dewachter, P Herpels, N Verstraeten, M Fauvart, J Michiels Scientific Reports 6 (1), 33723, 2016 | 20 | 2016 |
Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq L Dewachter, J Dénéréaz, X Liu, V de Bakker, C Costa, M Baldry, ... Elife 11, e75607, 2022 | 19 | 2022 |
Biochemical determinants of ObgE‐mediated persistence N Verstraeten, S Gkekas, CI Kint, B Deckers, B Van den Bergh, P Herpels, ... Molecular microbiology 112 (5), 1593-1608, 2019 | 10 | 2019 |
The bacterial cell cycle checkpoint protein Obg and its role in programmed cell death L Dewachter, N Verstraeten, M Fauvart, J Michiels Microbial cell 3 (6), 255, 2016 | 9 | 2016 |
GTP binding is necessary for the activation of a toxic mutant isoform of the essential GTPase ObgE L Dewachter, B Deckers, E Martin, P Herpels, S Gkekas, W Versées, ... International journal of molecular sciences 21 (1), 16, 2019 | 4 | 2019 |
YbiB: a novel interactor of the GTPase ObgE B Deckers, S Vercauteren, V De Kock, C Martin, T Lazar, P Herpels, ... Nucleic acids research 51 (7), 3420-3435, 2023 | 3 | 2023 |
Composition and liquid-to-solid maturation of protein aggregates contribute to bacterial dormancy development and recovery C Bollen, S Louwagie, F Deroover, W Duverger, L Khodaparast, ... Nature Communications 16 (1), 1046, 2025 | | 2025 |
The role of the essential GTPase ObgE in regulating lipopolysaccharide synthesis in Escherichia coli L Dewachter, B Deckers, I Mares-Mejía, E Louwagie, S Vercauteren, ... Nature communications 15 (1), 9684, 2024 | | 2024 |
The rise and future of CRISPR-based approaches for high-throughput genomics S Vercauteren, S Fiesack, L Maroc, N Verstraeten, L Dewachter, ... FEMS microbiology reviews 48 (5), fuae020, 2024 | | 2024 |