| A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases RC Coll, AAB Robertson, JJ Chae, SC Higgins, R Muñoz-Planillo, ... Nature medicine 21 (3), 248-255, 2015 | 2553 | 2015 |
| A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis AB Begovich, VEH Carlton, LA Honigberg, SJ Schrodi, AP Chokkalingam, ... The American Journal of Human Genetics 75 (2), 330-337, 2004 | 1925 | 2004 |
| Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes MF McDermott, I Aksentijevich, J Galon, EM McDermott, BW Ogunkolade, ... Cell 97 (1), 133-144, 1999 | 1699 | 1999 |
| Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci EA Stahl, S Raychaudhuri, EF Remmers, G Xie, S Eyre, BP Thomson, Y Li, ... Nature genetics 42 (6), 508-514, 2010 | 1619 | 2010 |
| Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease SL Masters, A Simon, I Aksentijevich, DL Kastner Annual review of immunology 27 (1), 621-668, 2009 | 1353 | 2009 |
| Activated STING in a vascular and pulmonary syndrome Y Liu, AA Jesus, B Marrero, D Yang, SE Ramsey, ... New England Journal of Medicine 371 (6), 507-518, 2014 | 1347 | 2014 |
| STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus EF Remmers, RM Plenge, AT Lee, RR Graham, G Hom, TW Behrens, ... New England Journal of Medicine 357 (10), 977-986, 2007 | 1341 | 2007 |
| The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP GS Lee, N Subramanian, AI Kim, I Aksentijevich, R Goldbach-Mansky, ... Nature 492 (7427), 123-127, 2012 | 1115 | 2012 |
| An autoinflammatory disease with deficiency of the interleukin-1–receptor antagonist I Aksentijevich, SL Masters, PJ Ferguson, P Dancey, J Frenkel, ... New England Journal of Medicine 360 (23), 2426-2437, 2009 | 1089 | 2009 |
| Neonatal-onset multisystem inflammatory disease responsive to interleukin-1β inhibition R Goldbach-Mansky, NJ Dailey, SW Canna, A Gelabert, J Jones, BI Rubin, ... New England Journal of Medicine 355 (6), 581-592, 2006 | 1075 | 2006 |
| TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study RM Plenge, M Seielstad, L Padyukov, AT Lee, EF Remmers, B Ding, ... New England Journal of Medicine 357 (12), 1199-1209, 2007 | 1062 | 2007 |
| Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS) AC Bulua, A Simon, R Maddipati, M Pelletier, H Park, KY Kim, MN Sack, ... Journal of Experimental Medicine 208 (3), 519-533, 2011 | 1021 | 2011 |
| Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease DB Beck, MA Ferrada, KA Sikora, AK Ombrello, JC Collins, W Pei, ... New England Journal of Medicine 383 (27), 2628-2638, 2020 | 917 | 2020 |
| Early-onset stroke and vasculopathy associated with mutations in ADA2 Q Zhou, D Yang, AK Ombrello, AV Zavialov, C Toro, AV Zavialov, ... New England Journal of Medicine 370 (10), 911-920, 2014 | 876 | 2014 |
| De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal‐onset multisystem inflammatory disease (NOMID … I Aksentijevich, M Nowak, M Mallah, JJ Chae, WT Watford, SR Hofmann, ... Arthritis & Rheumatism 46 (12), 3340-3348, 2002 | 873 | 2002 |
| A guiding map for inflammation MG Netea, F Balkwill, M Chonchol, F Cominelli, MY Donath, ... Nature immunology 18 (8), 826-831, 2017 | 794 | 2017 |
| Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease EF Remmers, F Cosan, Y Kirino, MJ Ombrello, N Abaci, C Satorius, JM Le, ... Nature genetics 42 (8), 698-702, 2010 | 793 | 2010 |
| The B30. 2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1β production JJ Chae, G Wood, SL Masters, K Richard, G Park, BJ Smith, DL Kastner Proceedings of the National Academy of Sciences 103 (26), 9982-9987, 2006 | 753 | 2006 |
| Replication of putative candidate-gene associations with rheumatoid arthritis in> 4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4 … RM Plenge, L Padyukov, EF Remmers, S Purcell, AT Lee, EW Karlson, ... The American Journal of Human Genetics 77 (6), 1044-1060, 2005 | 746 | 2005 |
| Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1 Y Kirino, G Bertsias, Y Ishigatsubo, N Mizuki, I Tugal-Tutkun, E Seyahi, ... Nature genetics 45 (2), 202-207, 2013 | 627 | 2013 |
