| Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos E Zuo, Y Sun, W Wei, T Yuan, W Ying, H Sun, L Yuan, LM Steinmetz, Y Li, ... Science 364 (6437), 289-292, 2019 | 791 | 2019 |
| Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis C Zhou, Y Sun, R Yan, Y Liu, E Zuo, C Gu, L Han, Y Wei, X Hu, R Zeng, ... Nature 571 (7764), 275-278, 2019 | 464 | 2019 |
| Glia-to-neuron conversion by CRISPR-CasRx alleviates symptoms of neurological disease in mice H Zhou, J Su, X Hu, C Zhou, H Li, Z Chen, Q Xiao, BO Wang, W Wu, ... Cell 181 (3), 590-603. e16, 2020 | 404 | 2020 |
| In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice H Zhou, J Liu, C Zhou, N Gao, Z Rao, H Li, X Hu, C Li, X Yao, X Shen, ... Nature neuroscience 21 (3), 440-446, 2018 | 293 | 2018 |
| One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs E Zuo, YJ Cai, K Li, Y Wei, BA Wang, Y Sun, Z Liu, J Liu, X Hu, W Wei, ... Cell research 27 (7), 933-945, 2017 | 222 | 2017 |
| Integrated omics of metastatic colorectal cancer C Li, YD Sun, GY Yu, JR Cui, Z Lou, H Zhang, Y Huang, CG Bai, LL Deng, ... Cancer cell 38 (5), 734-747. e9, 2020 | 216 | 2020 |
| CRISPR/Cas9-mediated targeted chromosome elimination E Zuo, X Huo, X Yao, X Hu, Y Sun, J Yin, B He, X Wang, L Shi, J Ping, ... Genome biology 18, 1-18, 2017 | 209 | 2017 |
| A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects E Zuo, Y Sun, T Yuan, B He, C Zhou, W Ying, J Liu, W Wei, R Zeng, Y Li, ... Nature Methods 17 (6), 600-604, 2020 | 135 | 2020 |
| Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex A Chen, Y Sun, Y Lei, C Li, S Liao, J Meng, Y Bai, Z Liu, Z Liang, Z Zhu, ... Cell 186 (17), 3726-3743. e24, 2023 | 103 | 2023 |
| Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome-and transcriptome-wide off-target effects S Lee, N Ding, Y Sun, T Yuan, J Li, Q Yuan, L Liu, J Yang, Q Wang, ... Science advances 6 (29), eaba1773, 2020 | 89 | 2020 |
| Highly efficient base editing in human tripronuclear zygotes C Zhou, M Zhang, Y Wei, Y Sun, Y Sun, H Pan, N Yao, W Zhong, Y Li, ... Protein & cell 8 (10), 772-775, 2017 | 68 | 2017 |
| Cynomolgus monkey embryo model captures gastrulation and early pregnancy J Li, Q Zhu, J Cao, Y Liu, Y Lu, Y Sun, Q Li, Y Huang, S Shang, X Bian, ... Cell Stem Cell 30 (4), 362-377. e7, 2023 | 60 | 2023 |
| Programmable C‐to‐U RNA editing using the human APOBEC 3A deaminase X Huang, J Lv, Y Li, S Mao, Z Li, Z Jing, Y Sun, X Zhang, S Shen, X Wang, ... The EMBO Journal 39 (22), e104741, 2020 | 56 | 2020 |
| Global prioritizing disease candidate lncRNAs via a multi-level composite network Q Yao, L Wu, J Li, LG Yang, Y Sun, Z Li, S He, F Feng, H Li, Y Li Scientific reports 7 (1), 39516, 2017 | 56 | 2017 |
| Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing H Zhang, H Pan, C Zhou, Y Wei, W Ying, S Li, G Wang, C Li, Y Ren, G Li, ... Development 145 (20), dev168906, 2018 | 55 | 2018 |
| Optimization of C-to-G base editors with sequence context preference predictable by machine learning methods T Yuan, N Yan, T Fei, J Zheng, J Meng, N Li, J Liu, H Zhang, L Xie, W Ying, ... Nature communications 12 (1), 4902, 2021 | 54 | 2021 |
| Pharmaco-proteogenomic characterization of liver cancer organoids for precision oncology S Ji, L Feng, Z Fu, G Wu, Y Wu, Y Lin, D Lu, Y Song, P Cui, Z Yang, ... Science translational medicine 15 (706), eadg3358, 2023 | 50 | 2023 |
| Human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors M Zhang, C Zhou, Y Wei, C Xu, H Pan, W Ying, Y Sun, Y Sun, Q Xiao, ... Genome biology 20, 1-7, 2019 | 44 | 2019 |
| Whole-brain spatial organization of hippocampal single-neuron projectomes S Qiu, Y Hu, Y Huang, T Gao, X Wang, D Wang, B Ren, X Shi, Y Chen, ... Science 383 (6682), eadj9198, 2024 | 32 | 2024 |
| Disruption of splicing-regulatory elements using CRISPR/Cas9 to rescue spinal muscular atrophy in human iPSCs and mice JJ Li, X Lin, C Tang, YQ Lu, X Hu, E Zuo, H Li, W Ying, Y Sun, LL Lai, ... National Science Review 7 (1), 92-101, 2020 | 32 | 2020 |
