| Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines … RA Sperling, PS Aisen, LA Beckett, DA Bennett, S Craft, AM Fagan, ... Alzheimer's & dementia 7 (3), 280-292, 2011 | 8553 | 2011 |
| Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium IG McKeith, DW Dickson, J Lowe, M Emre, JT O'brien, H Feldman, ... Neurology 65 (12), 1863-1872, 2005 | 5984 | 2005 |
| Membrane transporters in drug development Nature reviews Drug discovery 9 (3), 215-236, 2010 | 3629 | 2010 |
| Lecanemab in early Alzheimer’s disease CH Van Dyck, CJ Swanson, P Aisen, RJ Bateman, C Chen, M Gee, ... New England Journal of Medicine 388 (1), 9-21, 2023 | 3197 | 2023 |
| α-Synuclein is phosphorylated in synucleinopathy lesions H Fujiwara, M Hasegawa, N Dohmae, A Kawashima, E Masliah, ... Nature cell biology 4 (2), 160-164, 2002 | 2435 | 2002 |
| Visualization of Aβ42 (43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: evidence that an initially deposited species is Aβ42 (43) T Iwatsubo, A Odaka, N Suzuki, H Mizusawa, N Nukina, Y Ihara Neuron 13 (1), 45-53, 1994 | 2344 | 1994 |
| Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature PT Nelson, I Alafuzoff, EH Bigio, C Bouras, H Braak, NJ Cairns, ... Journal of Neuropathology & Experimental Neurology 71 (5), 362-381, 2012 | 2330 | 2012 |
| Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. M Baba, S Nakajo, PH Tu, T Tomita, K Nakaya, VM Lee, JQ Trojanowski, ... The American journal of pathology 152 (4), 879, 1998 | 2172 | 1998 |
| APP processing and synaptic function F Kamenetz, T Tomita, H Hsieh, G Seabrook, D Borchelt, T Iwatsubo, ... Neuron 37 (6), 925-937, 2003 | 2136 | 2003 |
| Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease RS Doody, RG Thomas, M Farlow, T Iwatsubo, B Vellas, S Joffe, ... New England Journal of Medicine 370 (4), 311-321, 2014 | 1867 | 2014 |
| AMPAR removal underlies Aβ-induced synaptic depression and dendritic spine loss H Hsieh, J Boehm, C Sato, T Iwatsubo, T Tomita, S Sisodia, R Malinow Neuron 52 (5), 831-843, 2006 | 1384 | 2006 |
| A phase 3 trial of semagacestat for treatment of Alzheimer's disease RS Doody, R Raman, M Farlow, T Iwatsubo, B Vellas, S Joffe, K Kieburtz, ... New England Journal of Medicine 369 (4), 341-350, 2013 | 1377 | 2013 |
| The amyloid-β pathway in Alzheimer’s disease H Hampel, J Hardy, K Blennow, C Chen, G Perry, SH Kim, VL Villemagne, ... Molecular psychiatry 26 (10), 5481-5503, 2021 | 1245 | 2021 |
| The role of presenilin cofactors in the γ-secretase complex N Takasugi, T Tomita, I Hayashi, M Tsuruoka, M Niimura, Y Takahashi, ... Nature 422 (6930), 438-441, 2003 | 1182 | 2003 |
| Two randomized phase 3 studies of aducanumab in early Alzheimer’s disease S Budd Haeberlein, PS Aisen, F Barkhof, S Chalkias, T Chen, S Cohen, ... The journal of prevention of Alzheimer's disease 9 (2), 197-210, 2022 | 963 | 2022 |
| Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein P Tu, JE Galvin, M Baba, B Giasson, T Tomita, S Leight, S Nakajo, ... Annals of neurology 44 (3), 415-422, 1998 | 763 | 1998 |
| Dominant and differential deposition of distinct β-amyloid peptide species, AβN3 (pE), in senile plaques TC Saido, T Iwatsubo, DMA Mann, H Shimada, Y Ihara, S Kawashima Neuron 14 (2), 457-466, 1995 | 758 | 1995 |
| Constitutive phosphorylation of the Parkinson's disease associated α-synuclein M Okochi, J Walter, A Koyama, S Nakajo, M Baba, T Iwatsubo, L Meijer, ... Journal of Biological Chemistry 275 (1), 390-397, 2000 | 741 | 2000 |
| DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers CF Lippa, JE Duda, M Grossman, HI Hurtig, D Aarsland, BF Boeve, ... Neurology 68 (11), 812-819, 2007 | 710 | 2007 |
| Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver K Ito, T Iwatsubo, S Kanamitsu, K Ueda, H Suzuki, Y Sugiyama Pharmacological reviews 50 (3), 387-412, 1998 | 661 | 1998 |
