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Lawrence Harris
Lawrence Harris
Principal Scientist, Ferrier Institute, Victoria University of Wellington
Zweryfikowany adres z vuw.ac.nz
Tytuł
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Cytowane przez
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Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective
M Seifert, SC Bera, P Van Nies, RN Kirchdoerfer, A Shannon, TTN Le, ...
Elife 10, e70968, 2021
732021
Alkyl 4-chlorobenzoyloxycarbamates as highly effective nitrogen source reagents for the base-free, intermolecular aminohydroxylation reaction
L Harris, SPH Mee, RH Furneaux, GJ Gainsford, A Luxenburger
The Journal of organic chemistry 76 (2), 358-372, 2011
572011
Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis
TV Pham, AS Murkin, MM Moynihan, L Harris, PC Tyler, N Shetty, ...
Proceedings of the National Academy of Sciences 114 (29), 7617-7622, 2017
522017
Substituted diaryldiazomethanes and diazofluorenes: structure, reactivity and stability
PJ Davis, L Harris, A Karim, AL Thompson, M Gilpin, MG Moloney, ...
Tetrahedron letters 52 (14), 1553-1556, 2011
502011
Synthesis and use of a trifluoromethylated azomethine ylide precursor
G Tran, R Meier, L Harris, DL Browne, SV Ley
The Journal of Organic Chemistry 77 (24), 11071-11078, 2012
402012
E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function
TD Godwin, ST Kelly, TP Brew, NM Bougen-Zhukov, AB Single, A Chen, ...
Gastric Cancer 22, 273-286, 2019
392019
A designed approach to enantiodivergent enamine catalysis
J Macharia, V Wambua, Y Hong, L Harris, JS Hirschi, GB Evans, ...
Angewandte Chemie 129 (30), 8882-8886, 2017
352017
Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases
Y Zhang, GB Evans, K Clinch, DR Crump, LD Harris, RFG Fröhlich, ...
Journal of Biological Chemistry 288 (48), 34746-34754, 2013
342013
Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication
JCC Hsu, M Laurent-Rolle, JB Pawlak, H Xia, A Kunte, JS Hee, J Lim, ...
Molecular cell 82 (9), 1631-1642. e6, 2022
312022
Chemical synthesis of the antiviral nucleotide analogue ddhCTP
JM Wood, GB Evans, TL Grove, SC Almo, SA Cameron, RH Furneaux, ...
The Journal of Organic Chemistry 86 (13), 8843-8850, 2021
162021
Uncatalysed diaryldiazo cyclopropanations on bicyclic lactams: access to annulated prolines
L Harris, M Gilpin, AL Thompson, AR Cowley, MG Moloney
Organic & Biomolecular Chemistry 13 (23), 6522-6550, 2015
152015
Signatures and mechanisms of efficacious therapeutic ribonucleotides against SARS-CoV-2 revealed by analysis of its replicase using magnetic tweezers
M Seifert, SC Bera, P van Nies, RN Kirchdoerfer, A Shannon, X Meng, ...
132020
Narrow-spectrum antibiotic targeting of the radical SAM enzyme MqnE in menaquinone biosynthesis
AG Carl, LD Harris, M Feng, LU Nordstrøm, GJ Gerfen, GB Evans, ...
Biochemistry 59 (27), 2562-2575, 2020
122020
Synthesis of 12β-methyl-18-nor-avicholic acid analogues as potential TGR5 agonists
EM Ure, LD Harris, SA Cameron, A Weymouth-Wilson, RH Furneaux, ...
Organic & Biomolecular Chemistry 20 (17), 3511-3527, 2022
82022
Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2R,3S)-2-Hydroxy-3-(nitromethyl)succinic acid
DM Mellott, D Torres, IV Krieger, SA Cameron, Z Moghadamchargari, ...
Journal of the American Chemical Society 143 (42), 17666-17676, 2021
72021
Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase
LD Harris, RK Harijan, RG Ducati, GB Evans, BM Hirsch, VL Schramm
ACS chemical biology 13 (1), 152-160, 2018
72018
A novel class of azatricyclononanes: pentasubstituted cyclopropanes from an uncatalysed reaction
L Harris, M Gilpin, AL Thompson, AR Cowley, MG Moloney
Tetrahedron: Asymmetry 20 (6-8), 726-729, 2009
72009
Synthesis of 12β-Methyl-18-nor-bile Acids
A Luxenburger, LD Harris, EM Ure, RA Landaeta Aponte, AD Woolhouse, ...
ACS omega 6 (38), 25019-25039, 2021
62021
The post-lockdown period should be used to acquire effective therapies for future resurgence in SARS-Cov-2 infections.
KL Krause, R Furneaux, P Benjes, M Brimble, T Davidson, W Denny, ...
Open Access Victoria University of Wellington| Te Herenga Waka, 2020
62020
Synthesis of novel C/D ring modified bile acids
RA Landaeta Aponte, A Luxenburger, SA Cameron, A Weymouth-Wilson, ...
Molecules 27 (7), 2364, 2022
52022
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