The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin–proteasome system SH Park, N Bolender, F Eisele, Z Kostova, J Takeuchi, P Coffino, DH Wolf Molecular biology of the cell 18 (1), 153-165, 2007 | 211 | 2007 |
Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1 F Eisele, DH Wolf FEBS letters 582 (30), 4143-4146, 2008 | 197 | 2008 |
FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism X Chen, B Ji, X Hao, X Li, F Eisele, T Nyström, D Petranovic Nature Communications 11 (1), 867, 2020 | 63 | 2020 |
Opposing roles of U bp3‐dependent deubiquitination regulate replicative life span and heat resistance D Öling, F Eisele, K Kvint, T Nyström The EMBO journal 33 (7), 747-761, 2014 | 62 | 2014 |
Syntaxin 5 is required for the formation and clearance of protein inclusions during proteostatic stress R Babazadeh, D Ahmadpour, S Jia, X Hao, P Widlund, K Schneider, ... Cell reports 28 (8), 2096-2110. e8, 2019 | 41 | 2019 |
Bacterial genotoxin triggers FEN1-dependent RhoA activation, cytoskeleton remodeling and cell survival L Guerra, R Guidi, I Slot, S Callegari, R Sompallae, CL Pickett, S Åström, ... Journal of cell science 124 (16), 2735-2742, 2011 | 37 | 2011 |
An Hsp90 co-chaperone links protein folding and degradation and is part of a conserved protein quality control F Eisele, AM Eisele-Bürger, X Hao, LL Berglund, JL Höög, B Liu, ... Cell reports 35 (13), 2021 | 28 | 2021 |
Mutants of the deubiquitinating enzyme Ubp14 decipher pathway diversity of ubiquitin–proteasome linked protein degradation F Eisele, B Braun, T Pfirrmann, DH Wolf Biochemical and biophysical research communications 350 (2), 329-333, 2006 | 26 | 2006 |
Differential role of cytosolic Hsp70s in longevity assurance and protein quality control R Andersson, AM Eisele-Bürger, S Hanzén, K Vielfort, D Öling, F Eisele, ... PLoS genetics 17 (1), e1008951, 2021 | 22 | 2021 |
The Cdc48–Ufd1–Npl4 complex is central in ubiquitin–proteasome triggered catabolite degradation of fructose-1, 6-bisphosphatase L Barbin, F Eisele, O Santt, DH Wolf Biochemical and biophysical research communications 394 (2), 335-341, 2010 | 22 | 2010 |
Arabidopsis metacaspase MC1 localizes in stress granules, clears protein aggregates, and delays senescence N Ruiz-Solaní, J Salguero-Linares, L Armengot, J Santos, I Pallarès, ... The Plant Cell 35 (9), 3325-3344, 2023 | 16 | 2023 |
Rapid PROTAC discovery platform: nanomole-scale array synthesis and direct screening of reaction mixtures MP Plesniak, EK Taylor, F Eisele, CMBK Kourra, IN Michaelides, A Oram, ... ACS Medicinal Chemistry Letters 14 (12), 1882-1890, 2023 | 15 | 2023 |
Using reporters of different misfolded proteins reveals differential strategies in processing protein aggregates KL Schneider, D Ahmadpour, KS Keuenhof, AM Eisele-Bürger, ... Journal of Biological Chemistry 298 (11), 2022 | 12 | 2022 |
Ubiquitylation in the ERAD pathway F Eisele, A Schäfer, DH Wolf Conjugation and Deconjugation of Ubiquitin Family Modifiers: Subcellular …, 2010 | 11 | 2010 |
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders SCC Lucas, A Ahmed, SN Ashraf, A Argyrou, MR Bauer, GM De Donatis, ... Journal of Medicinal Chemistry 67 (7), 5538-5566, 2024 | 3 | 2024 |
Components and mechanisms of cytoplasmic protein quality control and elimination of regulatory enzymes F Eisele | 3 | 2011 |
Calmodulin regulates protease versus co-chaperone activity of a metacaspase AM Eisele-Bürger, F Eisele, SM Hill, X Hao, KL Schneider, R Imamoglu, ... Cell Reports 42 (11), 2023 | 1 | 2023 |
Rapid PROTAC discovery platform: nanomole scale array synthesis and direct screening of reaction mixtures to facilitate the expedited discovery and follow-up of PROTAC hits. M Plesniak, EK Taylor, F Eisele, CMBK Kourra, I Michaelides, A Oram, ... | 1 | 2023 |
The cytoplasmic Hsp70 chaperone machinery subjects misfolded and ER import incompetent proteins to degradation via the ubiquitin-proteasome system. SH Park, N Bolender, F Eisele, Z Kostova, J Takeuchi, P Coffino, DH Wolf | 1 | |
Unveiling the Power of PROTAC Valency: Navigating Cell Type-Specific Hook Effects A Chitsazan, F Eisele, P Rabieifar, H Park, M Nordberg, J Liu, ... bioRxiv, 2024.06. 12.598404, 2024 | | 2024 |