The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5 F Hayashi, KD Smith, A Ozinsky, TR Hawn, EC Yi, DR Goodlett, JK Eng, ... Nature 410 (6832), 1099-1103, 2001 | 4941 | 2001 |
Toll-like receptors in the induction of the innate immune response A Aderem, RJ Ulevitch Nature 406 (6797), 782-787, 2000 | 4480 | 2000 |
Mechanisms of phagocytosis in macrophages A Aderem, DM Underhill Annual review of immunology 17 (1), 593-623, 1999 | 4194 | 1999 |
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors A Ozinsky, DM Underhill, JD Fontenot, AM Hajjar, KD Smith, CB Wilson, ... Proceedings of the National Academy of Sciences 97 (25), 13766-13771, 2000 | 2869 | 2000 |
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron TH Flo, KD Smith, S Sato, DJ Rodriguez, MA Holmes, RK Strong, S Akira, ... Nature 432 (7019), 917-921, 2004 | 2211 | 2004 |
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens DM Underhill, A Ozinsky, AM Hajjar, A Stevens, CB Wilson, M Bassetti, ... Nature 401 (6755), 811-815, 1999 | 1869 | 1999 |
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria EA Miao, IA Leaf, PM Treuting, DP Mao, M Dors, A Sarkar, SE Warren, ... Nature immunology 11 (12), 1136-1142, 2010 | 1472 | 2010 |
The evolution of vertebrate Toll-like receptors JC Roach, G Glusman, L Rowen, A Kaur, MK Purcell, KD Smith, LE Hood, ... Proceedings of the National Academy of Sciences 102 (27), 9577-9582, 2005 | 1461 | 2005 |
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf EA Miao, CM Alpuche-Aranda, M Dors, AE Clark, MW Bader, SI Miller, ... Nature immunology 7 (6), 569-575, 2006 | 1404 | 2006 |
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans TD Querec, RS Akondy, EK Lee, W Cao, HI Nakaya, D Teuwen, A Pirani, ... Nature immunology 10 (1), 116-125, 2009 | 1281 | 2009 |
Caspase‐1‐induced pyroptotic cell death EA Miao, JV Rajan, A Aderem Immunological reviews 243 (1), 206-214, 2011 | 1270 | 2011 |
Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages DM Underhill, A Ozinsky, KD Smith, A Aderem Proceedings of the National Academy of Sciences 96 (25), 14459-14463, 1999 | 1127 | 1999 |
Pyogenic bacterial infections in humans with IRAK-4 deficiency C Picard, A Puel, M Bonnet, CL Ku, J Bustamante, K Yang, C Soudais, ... Science 299 (5615), 2076-2079, 2003 | 1110 | 2003 |
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility KD Smith, E Andersen-Nissen, F Hayashi, K Strobe, MA Bergman, ... Nature immunology 4 (12), 1247-1253, 2003 | 1019 | 2003 |
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity JW Schoggins, DA MacDuff, N Imanaka, MD Gainey, B Shrestha, ... Nature 505 (7485), 691-695, 2014 | 981 | 2014 |
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism C Werts, RI Tapping, JC Mathison, TH Chuang, V Kravchenko, ... Nature immunology 2 (4), 346-352, 2001 | 975 | 2001 |
Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome EA Miao, DP Mao, N Yudkovsky, R Bonneau, CG Lorang, SE Warren, ... Proceedings of the National Academy of Sciences 107 (7), 3076-3080, 2010 | 934 | 2010 |
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4 M Gilchrist, V Thorsson, B Li, AG Rust, M Korb, K Kennedy, T Hai, ... Nature 441 (7090), 173-178, 2006 | 904 | 2006 |
Systems biology of vaccination for seasonal influenza in humans HI Nakaya, J Wrammert, EK Lee, L Racioppi, S Marie-Kunze, WN Haining, ... Nature immunology 12 (8), 786-795, 2011 | 901 | 2011 |
MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin JH Hartwig, M Thelen, A Resen, PA Janmey, AC Nairn, A Aderem Nature 356 (6370), 618-622, 1992 | 901 | 1992 |