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Alexander J Ohnmacht
Alexander J Ohnmacht
Helmholtz Munich
Zweryfikowany adres z helmholtz-munich.de
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Artificial intelligence in early drug discovery enabling precision medicine
F Boniolo, E Dorigatti, AJ Ohnmacht, D Saur, B Schubert, MP Menden
Expert Opinion on Drug Discovery 16 (9), 991-1007, 2021
1072021
The Oncology Biomarker Discovery framework reveals cetuximab and bevacizumab response patterns in metastatic colorectal cancer
AJ Ohnmacht, A Stahler, S Stintzing, DP Modest, JW Holch, ...
Nature communications 14 (1), 5391, 2023
92023
Can artificial intelligence accelerate preclinical drug discovery and precision medicine?
A Farnoud, AJ Ohnmacht, M Meinel, MP Menden
Expert Opinion on Drug Discovery 17 (7), 661-665, 2022
62022
The pharmacoepigenomic landscape of cancer cell lines reveals the epigenetic component of drug sensitivity
AJ Ohnmacht, A Rajamani, G Avar, G Kutkaite, E Gonçalves, D Saur, ...
Communications Biology 6 (1), 825, 2023
52023
Refining first-line treatment decision in RAS wildtype (RAS-WT) metastatic colorectal cancer (mCRC) by combining clinical biomarkers: Results of the randomized phase 3 trial …
JW Holch, AJ Ohnmacht, S Stintzing, K Heinrich, B Westphalen, L Weiss, ...
Journal of Clinical Oncology 42 (3_suppl), 13-13, 2024
22024
Inferred ancestral origin of cancer cell lines associates with differential drug response
PBH Nguyen, AJ Ohnmacht, S Sharifli, MJ Garnett, MP Menden
International Journal of Molecular Sciences 22 (18), 10135, 2021
22021
The pharmacogenomic assessment of molecular epithelial-mesenchymal transition signatures reveals drug susceptibilities in cancer cell lines
AJ Ohnmacht, G Avar, MK Schübel, TJ O’Neill, D Krappmann, ...
bioRxiv, 2024.01. 16.575190, 2024
12024
Enhancing Gene Expression Representation and Drug Response Prediction with Data Augmentation and Gene Emphasis
D Lu, DPS Pamar, AJ Ohnmacht, G Kutkaite, MP Menden
bioRxiv, 2024.05. 15.592959, 2024
2024
DNA methylation profiling refines the prognostic classification of acute myeloid leukemia patients treated with intensive chemotherapy
S Vosberg, AJ Ohnmacht, C Moser, A Arneth, V Jurinovic, KH Metzeler, ...
HemaSphere 6, 378-379, 2022
2022
FOLFIRI with Cetuximab or Bevacizumab in RAS Wild-Type Metastatic Colorectal Cancer: Refining First-Line Treatment Selection by Combining Clinical Parameters-A post hoc …
JW Holch, AJ Ohnmacht, S Stintzing, K Heinrich, L Weiss, V Probst, ...
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