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Bernardo P. de Almeida
Bernardo P. de Almeida
AI Senior Research Scientist, InstaDeep
Email confirmado em instadeep.com
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DeepSTARR predicts enhancer activity from DNA sequence and enables the de novo design of synthetic enhancers
BP de Almeida, F Reiter, M Pagani, A Stark
Nature genetics 54 (5), 613-624, 2022
1882022
Nucleotide Transformer: building and evaluating robust foundation models for human genomics
H Dalla-Torre, L Gonzalez, J Mendoza-Revilla, N Lopez Carranza, ...
Nature Methods, 1-11, 2024
1682024
Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers
BP de Almeida, JD Apolónio, A Binnie, P Castelo-Branco
BMC cancer 19, 1-12, 2019
1442019
Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
G Marteil, A Guerrero, AF Vieira, BP De Almeida, P Machado, ...
Nature communications 9 (1), 1258, 2018
1402018
Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome
BP de Almeida, AF Vieira, J Paredes, M Bettencourt-Dias, ...
PLoS computational biology 15 (3), e1006832, 2019
582019
Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis
S Braun, M Enculescu, ST Setty, M Cortés-López, BP de Almeida, ...
Nature communications 9 (1), 3315, 2018
542018
Allosteric antagonist modulation of TRPV2 by piperlongumine impairs glioblastoma progression
J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, BB Sousa, ...
ACS Central Science 7 (5), 868-881, 2021
502021
The nucleotide transformer: Building and evaluating robust foundation models for human genomics. bioRxiv
H Dalla-Torre, L Gonzalez, J Mendoza-Revilla, NL Carranza, ...
482023
Targeted design of synthetic enhancers for selected tissues in the Drosophila embryo
BP de Almeida, C Schaub, M Pagani, S Secchia, EEM Furlong, A Stark
Nature 626 (7997), 207-211, 2024
472024
Expression of receptor activator of NFkB (RANK) drives stemness and resistance to therapy in ER+ HER2-breast cancer
I Gomes, BP de Almeida, S Dâmaso, A Mansinho, I Correia, S Henriques, ...
Oncotarget 11 (19), 1714, 2020
282020
A foundational large language model for edible plant genomes
J Mendoza-Revilla, E Trop, L Gonzalez, M Roller, H Dalla-Torre, ...
Communications Biology 7 (1), 835, 2024
222024
Enhancers display constrained sequence flexibility and context-specific modulation of motif function
F Reiter, BP de Almeida, A Stark
Genome Research 33 (3), 346-358, 2023
122023
Advancing dna language models: The genomics long-range benchmark
CH Kao, E Trop, MK Polen, Y Schiff, BP de Almeida, A Gokaslan, T Pierrot, ...
ICLR 2024 Workshop on Machine Learning for Genomics Explorations, 2024
102024
SegmentNT: annotating the genome at single-nucleotide resolution with DNA foundation models
BP de Almeida, H Dalla-Torre, G Richard, C Blum, L Hexemer, M Gélard, ...
bioRxiv, 2024.03. 14.584712, 2024
102024
Chatnt: A multimodal conversational agent for dna, rna and protein tasks
G Richard, BP de Almeida, H Dalla-Torre, C Blum, L Hexemer, P Pandey, ...
bioRxiv, 2024.04. 30.591835, 2024
92024
Natural product–drug conjugates for modulation of TRPV1-expressing tumors
C Baker, T Rodrigues, BP de Almeida, NL Barbosa-Morais, ...
Bioorganic & Medicinal Chemistry 27 (12), 2531-2536, 2019
92019
Dissecting celastrol with machine learning to unveil dark pharmacology
T Rodrigues, BP de Almeida, NL Barbosa-Morais, GJL Bernardes
Chemical Communications 55 (45), 6369-6372, 2019
92019
Systematic identification and characterization of repressive domains in Drosophila transcription factors
L Klaus, BP de Almeida, A Vlasova, F Nemčko, A Schleiffer, K Bergauer, ...
The EMBO Journal 42 (3), e112100, 2023
82023
Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant
L Correia, R Magno, JM Xavier, BP de Almeida, I Duarte, F Esteves, ...
NPJ breast cancer 8 (1), 71, 2022
82022
DeepSTARR predicts enhancer activity from DNA sequence and enables the de novo design of enhancers
BP de Almeida, F Reiter, M Pagani, A Stark
bioRxiv, 2021.10. 05.463203, 2021
52021
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