| Genetic alterations during colorectal-tumor development B Vogelstein, ER Fearon, SR Hamilton, SE Kern, AC Preisinger, ... New England Journal of Medicine 319 (9), 525-532, 1988 | 9407 | 1988 |
| ras Oncogenes in Human Cancer: A Review JL Bos Cancer research 49 (17), 4682-4689, 1989 | 5790 | 1989 |
| Prevalence of ras gene mutations in human colorectal cancers JL Bos, ER Fearon, SR Hamilton, MV Vries, JH van Boom, AJ van der Eb, ... Nature 327 (6120), 293-297, 1987 | 2514 | 1987 |
| Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP J De Rooij, FJT Zwartkruis, MHG Verheijen, RH Cool, SMB Nijman, ... Nature 396 (6710), 474-477, 1998 | 2489 | 1998 |
| GEFs and GAPs: critical elements in the control of small G proteins JL Bos, H Rehmann, A Wittinghofer Cell 129 (5), 865-877, 2007 | 2474 | 2007 |
| Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress GJPL Kops, TB Dansen, PE Polderman, I Saarloos, KWA Wirtz, PJ Coffer, ... Nature 419 (6904), 316-321, 2002 | 1863 | 2002 |
| AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 RH Medema, GJPL Kops, JL Bos, BMT Burgering Nature 404 (6779), 782-787, 2000 | 1845 | 2000 |
| Direct control of the Forkhead transcription factor AFX by protein kinase B GJPL Kops, ND Ruiter, AMM De Vries-Smits, DR Powell, JL Bos, ... Nature 398 (6728), 630-634, 1999 | 1418 | 1999 |
| Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 A Garami, FJT Zwartkruis, T Nobukuni, M Joaquin, M Roccio, H Stocker, ... Molecular cell 11 (6), 1457-1466, 2003 | 1298 | 2003 |
| The ras gene family and human carcinogenesis JL Bos Mutation Research/Reviews in Genetic Toxicology 195 (3), 255-271, 1988 | 1116 | 1988 |
| K-ras Oncogene Activation as a Prognostic Marker in Adenocarcinoma of the Lung RJC Slebos, RE Kibbelaar, O Dalesio, A Kooistra, J Stam, CJLM Meijer, ... New England Journal of Medicine 323 (9), 561-565, 1990 | 999 | 1990 |
| Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase T Nobukuni, M Joaquin, M Roccio, SG Dann, SY Kim, P Gulati, MP Byfield, ... Proceedings of the National Academy of Sciences 102 (40), 14238-14243, 2005 | 963 | 2005 |
| FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK MAG Essers, S Weijzen, AMM de Vries‐Smits, I Saarloos, ND de Ruiter, ... The EMBO journal 23 (24), 4802-4812, 2004 | 933 | 2004 |
| K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele … RH Hruban, AD Van Mansfeld, GJ Offerhaus, DH Van Weering, ... The American journal of pathology 143 (2), 545, 1993 | 896 | 1993 |
| A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK JM Enserink, AE Christensen, J de Rooij, M van Triest, F Schwede, ... Nature cell biology 4 (11), 901-906, 2002 | 845 | 2002 |
| KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas VT Smit, AJM Boot, AMM Smits, GJ Fleuren, CJ Cornelisse, JL Bos Nucleic acids research 16 (16), 7773-7782, 1988 | 818 | 1988 |
| Rap1 signalling: adhering to new models JL Bos, J de Rooij, KA Reedquist Nature reviews Molecular cell biology 2 (5), 369-377, 2001 | 769 | 2001 |
| An organoid platform for ovarian cancer captures intra-and interpatient heterogeneity O Kopper, CJ De Witte, K Lõhmussaar, JE Valle-Inclan, N Hami, L Kester, ... Nature medicine 25 (5), 838-849, 2019 | 740 | 2019 |
| Epac proteins: multi-purpose cAMP targets JL Bos Trends in biochemical sciences 31 (12), 680-686, 2006 | 689 | 2006 |
| Mutational Activation of the K-ras Oncogene S Rodenhuis, ML van de Wetering, WJ Mooi, SG Evers, N van Zandwijk, ... New England Journal of Medicine 317 (15), 929-935, 1987 | 689 | 1987 |
