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Oscar G. Wilkins
Oscar G. Wilkins
Adresă de e-mail confirmată pe ucl.ac.uk
Titlu
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TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
AL Brown, OG Wilkins, MJ Keuss, SE Hill, M Zanovello, WC Lee, ...
Nature 603 (7899), 131-137, 2022
3352022
Highly disordered histone H1− DNA model complexes and their condensates
AL Turner, M Watson, OG Wilkins, L Cato, A Travers, JO Thomas, K Stott
Proceedings of the National Academy of Sciences 115 (47), 11964-11969, 2018
2052018
Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD
S Seddighi, YA Qi, AL Brown, OG Wilkins, C Bereda, C Belair, YJ Zhang, ...
Science translational medicine 16 (734), eadg7162, 2024
842024
FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation
N Birsa, AM Ule, MG Garone, B Tsang, F Mattedi, PA Chong, J Humphrey, ...
Science Advances 7 (30), eabf8660, 2021
572021
MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration
R Simone, F Javad, W Emmett, OG Wilkins, FL Almeida, ...
Nature 594 (7861), 117-123, 2021
512021
Ultraplex: A rapid, flexible, all-in-one fastq demultiplexer
OG Wilkins, C Capitanchik, NM Luscombe, J Ule
Wellcome Open Research 6, 141, 2021
302021
An improved iCLIP protocol
FCY Lee, AM Chakrabarti, H Hänel, E Monzón-Casanova, M Hallegger, ...
BioRxiv, 2021.08. 27.457890, 2021
262021
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS
S Seddighi, YA Qi, AL Brown, OG Wilkins, C Bereda, C Belair, Y Zhang, ...
FTD. bioRxiv 2023 (2023.525149), 10.1126, 2023
252023
Consortium
AL Brown, OG Wilkins, MJ Keuss, SE Hill, M Zanovello, WC Lee, ...
NA, Newcombe, J., Gustavsson, EK, Seddighi, S.,… Maggin, D, 2022
242022
Identifying ribosome heterogeneity using ribosome profiling
F Alkan, OG Wilkins, S Hernández-Pérez, S Ramalho, J Silva, J Ule, ...
Nucleic acids research 50 (16), e95-e95, 2022
192022
Creation of de novo cryptic splicing for ALS and FTD precision medicine
OG Wilkins, MZYJ Chien, JJ Wlaschin, S Barattucci, P Harley, F Mattedi, ...
Science 386 (6717), 61-69, 2024
82024
TDP-43 loss induces extensive cryptic polyadenylation in ALS/FTD
S Bryce-Smith, AL Brown, PR Mehta, F Mattedi, A Mikheenko, S Barattucci, ...
BioRxiv, 2024
82024
Loss of TDP-43 induces synaptic dysfunction that is rescued by UNC13A splice-switching ASOs
MJ Keuss, P Harley, E Ryadnov, RE Jackson, M Zanovello, OG Wilkins, ...
BioRxiv, 2024
72024
Ribocutter: Cas9-mediated rRNA depletion from multiplexed Ribo-seq libraries
OG Wilkins, J Ule
Biorxiv, 2021.07. 14.451473, 2021
62021
From computational models of the splicing code to regulatory mechanisms and therapeutic implications
C Capitanchik, OG Wilkins, N Wagner, J Gagneur, J Ule
Nature Reviews Genetics, 1-20, 2024
22024
Flow: a web platform and open database to analyse, store, curate and share bioinformatics data at scale
C Capitanchik, S Ireland, A Harston, C Cheshire, DM Jones, FCY Lee, ...
bioRxiv, 2023.08. 22.544179, 2023
22023
Mutual homeostasis of charged proteins
R Faraway, NC Heaven, H Digby, OG Wilkins, AM Chakrabarti, IA Iosub, ...
bioRxiv, 2023.08. 21.554177, 2023
22023
Therapeutics for the treatment of neurodegenerative disorders
P Fratta, AL Brown, O Wilkins, M Keuss, M Ward, S Hill
US Patent App. 18/920,273, 2025
2025
THERAPEUTICS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
P Fratta, AL Brown, O Wilkins, M Keuss, M Ward, S Hill
US Patent App. 18/266,210, 2024
2024
Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
AL Brown, OG Wilkins, MJ Keuss, SE Hill, M Zanovello, WC Lee, ...
Nature 631 (8020), E7-E7, 2024
2024
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