| Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis MJ Taylor, TW von Geldern, L Ford, MP Hübner, K Marsh, KL Johnston, ... Science translational medicine 11 (483), eaau2086, 2019 | 80 | 2019 |
| Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and … G Aljayyoussi, HE Tyrer, L Ford, H Sjoberg, N Pionnier, D Waterhouse, ... Scientific reports 7 (1), 210, 2017 | 78 | 2017 |
| AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis WD Hong, F Benayoud, GL Nixon, L Ford, KL Johnston, RH Clare, ... Proceedings of the National Academy of Sciences 116 (4), 1414-1419, 2019 | 72 | 2019 |
| The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming JM Gutiérrez, LO Albulescu, RH Clare, NR Casewell, TM Abd El-Aziz, ... Toxins 13 (7), 451, 2021 | 66 | 2021 |
| Development and Validation of a High-Throughput Anti-Wolbachia Whole-Cell Screen: A Route to Macrofilaricidal Drugs against Onchocerciasis and Lymphatic … RH Clare, DAN Cook, KL Johnston, L Ford, SA Ward, MJ Taylor Journal of biomolecular screening 20 (1), 64-69, 2015 | 63 | 2015 |
| Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides RH Clare, C Bardelle, P Harper, WD Hong, U Börjesson, KL Johnston, ... Nature communications 10 (1), 11, 2019 | 61 | 2019 |
| Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis JD Turner, R Sharma, G Al Jayoussi, HE Tyrer, J Gamble, L Hayward, ... Proceedings of the National Academy of Sciences 114 (45), E9712-E9721, 2017 | 60 | 2017 |
| Small molecule drug discovery for neglected tropical snakebite RH Clare, SR Hall, RN Patel, NR Casewell Trends in pharmacological sciences 42 (5), 340-353, 2021 | 51 | 2021 |
| Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis RT Jacobs, CS Lunde, YR Freund, V Hernandez, X Li, Y Xia, DS Carter, ... Journal of medicinal chemistry 62 (5), 2521-2540, 2019 | 44 | 2019 |
| Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic … R Sharma, GA Jayoussi, HE Tyrer, J Gamble, L Hayward, AF Guimaraes, ... Scientific reports 6 (1), 23458, 2016 | 43 | 2016 |
| Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library KL Johnston, DAN Cook, NG Berry, W David Hong, RH Clare, M Goddard, ... Science advances 3 (9), eaao1551, 2017 | 33 | 2017 |
| In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus SK Menzies, RH Clare, C Xie, A Westhorpe, SR Hall, RJ Edge, J Alsolaiss, ... Toxicon: X 14, 100118, 2022 | 21 | 2022 |
| Development of a High-Throughput Cytometric Screen to Identify Anti-Wolbachia Compounds: The Power of Public–Private Partnership RH Clare, R Clark, C Bardelle, P Harper, M Collier, KL Johnston, H Plant, ... SLAS DISCOVERY: Advancing Life Sciences R&D 24 (5), 537-547, 2019 | 13 | 2019 |
| Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors RH Clare, CA Dawson, A Westhorpe, LO Albulescu, CM Woodley, ... Frontiers in Pharmacology 14, 1328950, 2024 | 10 | 2024 |
| An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules RN Patel, RH Clare, L Ledsgaard, M Nys, J Kool, AH Laustsen, C Ulens, ... Biochemical pharmacology 216, 115758, 2023 | 9 | 2023 |
| Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis P McGillan, NG Berry, GL Nixon, SC Leung, PJH Webborn, MC Wenlock, ... ACS Medicinal Chemistry Letters 12 (9), 1421-1426, 2021 | 7 | 2021 |
| African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: evidence for increasing antivenom … G Solano, S Cunningham, RJ Edge, G Duran, A Sanchez, M Villalta, ... BMJ global health 9 (3), e014813, 2024 | 6 | 2024 |
| Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform LO Albulescu, A Westhorpe, RH Clare, CM Woodley, N James, J Kool, ... Frontiers in pharmacology 14, 1331224, 2024 | 4 | 2024 |
| Intraspecific venom variation in the medically important puff adder (Bitis arietans): Comparative venom gland transcriptomics, in vitro venom activity and … CA Dawson, KE Bartlett, MC Wilkinson, S Ainsworth, LO Albulescu, ... PLOS Neglected Tropical Diseases 18 (10), e0012570, 2024 | 3 | 2024 |
| Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis R Sharma, G Aljayyoussi, HE Tyrer, J Gamble, L Hayward, AF Guimaraes, ... Scientific Reports 8, 46934, 2018 | 2 | 2018 |
Kelly L. JohnstonSenior Lecturer in Tropical Disease Biology, Liverpool School of Tropical MedicineAdresă de e-mail confirmată pe lstmed.ac.uk