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Brian Leber
Brian Leber
Professor of Medicine, McMaster University
Adresă de e-mail confirmată pe mcmaster.ca
Titlu
Citat de
Citat de
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Azacitidine and venetoclax in previously untreated acute myeloid leukemia
CD DiNardo, BA Jonas, V Pullarkat, MJ Thirman, JS Garcia, AH Wei, ...
New England journal of medicine 383 (7), 617-629, 2020
23062020
Telomerase activity in normal leukocytes and in hematologic malignancies
CM Counter, J Gupta, CB Harley, B Leber, S Bacchetti
11761995
Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis
E Daugas, SA Susin, N Zamzami, KF Ferri, T Irinopoulou, N Larochette, ...
The FASEB Journal 14 (5), 729-739, 2000
10772000
Mechanisms of action of Bcl-2 family proteins
A Shamas-Din, J Kale, B Leber, DW Andrews
Cold Spring Harbor perspectives in biology 5 (4), a008714, 2013
9162013
Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
JF Lovell, LP Billen, S Bindner, A Shamas-Din, C Fradin, B Leber, ...
Cell 135 (6), 1074-1084, 2008
7142008
Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells
E Sachlos, RM Risueño, S Laronde, Z Shapovalova, JH Lee, J Russell, ...
Cell 149 (6), 1284-1297, 2012
5752012
BH3-only proteins: Orchestrators of apoptosis
A Shamas-Din, H Brahmbhatt, B Leber, DW Andrews
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1813 (4), 508-520, 2011
5422011
Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator
C Brenner, H Cadiou, HLA Vieira, N Zamzami, I Marzo, Z Xie, B Leber, ...
Oncogene 19 (3), 329-336, 2000
5142000
Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes
B Leber, J Lin, DW Andrews
Apoptosis 12, 897-911, 2007
4772007
Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis
MG Annis, EL Soucie, PJ Dlugosz, JA Cruz‐Aguado, LZ Penn, B Leber, ...
The EMBO journal 24 (12), 2096-2103, 2005
4762005
Bcl‐2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.
W Zhu, A Cowie, GW Wasfy, LZ Penn, B Leber, DW Andrews
The EMBO journal 15 (16), 4130-4141, 1996
4341996
Bcl-XL inhibits membrane permeabilization by competing with Bax
LP Billen, CL Kokoski, JF Lovell, B Leber, DW Andrews
PLoS biology 6 (6), e147, 2008
3972008
Long-term outcome of a pediatric-inspired regimen used for adults aged 18–50 years with newly diagnosed acute lymphoblastic leukemia
DJ DeAngelo, KE Stevenson, SE Dahlberg, LB Silverman, S Couban, ...
Leukemia 29 (3), 526-534, 2015
3532015
Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin
S Assouline, B Culjkovic, E Cocolakis, C Rousseau, N Beslu, A Amri, ...
Blood 114 (2), 257-260, 2009
3462009
Bcl‐2 changes conformation to inhibit Bax oligomerization
PJ Dlugosz, LP Billen, MG Annis, W Zhu, Z Zhang, J Lin, B Leber, ...
The EMBO journal 25 (11), 2287-2296, 2006
3442006
Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy
CJ Owen, CL Toze, A Koochin, DL Forrest, CA Smith, JM Stevens, ...
Blood, The Journal of the American Society of Hematology 112 (12), 4639-4645, 2008
2862008
Campath-1H treatment of T-cell prolymphocytic leukemia in patients for whom at least one prior chemotherapy regimen has failed
MJ Keating, B Cazin, S Coutre, R Birhiray, T Kovacsovics, W Langer, ...
Journal of Clinical Oncology 20 (1), 205-213, 2002
2492002
Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis
JA Yethon, RF Epand, B Leber, RM Epand, DW Andrews
Journal of Biological Chemistry 278 (49), 48935-48941, 2003
2412003
Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche
AL Boyd, JC Reid, KR Salci, L Aslostovar, YD Benoit, Z Shapovalova, ...
Nature cell biology 19 (11), 1336-1347, 2017
2122017
Still embedded together binding to membranes regulates Bcl-2 protein interactions
B Leber, J Lin, DW Andrews
Oncogene 29 (38), 5221-5230, 2010
2092010
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