| The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration CL Le Maitre, AJ Freemont, JA Hoyland Arthritis research & therapy 7, 1-14, 2005 | 1010 | 2005 |
| Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile CL Le Maitre, JA Hoyland, AJ Freemont Arthritis research & therapy 9, 1-11, 2007 | 698 | 2007 |
| Matrix synthesis and degradation in human intervertebral disc degeneration CL Le Maitre, A Pockert, DJ Buttle, AJ Freemont, JA Hoyland Biochemical Society Transactions 35 (4), 652-655, 2007 | 627 | 2007 |
| Nerve growth factor expression and innervation of the painful intervertebral disc AJ Freemont, A Watkins, C Le Maitre, P Baird, M Jeziorska, MTN Knight, ... The Journal of pathology 197 (3), 286-292, 2002 | 597 | 2002 |
| Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc CL Le Maitre, AJ Freemont, JA Hoyland The Journal of Pathology: A Journal of the Pathological Society of Great …, 2004 | 584 | 2004 |
| Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration CL Le Maitre, AJ Freemont, JA Hoyland Arthritis research & therapy 9, 1-12, 2007 | 544 | 2007 |
| Molecular mechanisms of biological aging in intervertebral discs NV Vo, RA Hartman, PR Patil, MV Risbud, D Kletsas, JC Iatridis, ... Journal of orthopaedic research 34 (8), 1289-1306, 2016 | 419 | 2016 |
| Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc JA Hoyland, C Le Maitre, AJ Freemont Rheumatology 47 (6), 809-814, 2008 | 342 | 2008 |
| Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration AJ Pockert, SM Richardson, CL Le Maitre, M Lyon, JA Deakin, DJ Buttle, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2009 | 310 | 2009 |
| Current understanding of cellular and molecular events in intervertebral disc degeneration: implications for therapy AJ Freemont, A Watkins, C Le Maitre, M Jeziorska, JA Hoyland The Journal of Pathology: A Journal of the Pathological Society of Great …, 2002 | 294 | 2002 |
| Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic … CL Le Maitre, JA Hoyland, AJ Freemont Arthritis research & therapy 9, 1-12, 2007 | 218 | 2007 |
| Tumor necrosis factor α–and interleukin‐1β–dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1 J Wang, Y Tian, KLE Phillips, N Chiverton, G Haddock, RA Bunning, ... Arthritis & rheumatism 65 (3), 832-842, 2013 | 191 | 2013 |
| Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration A La Binch, AA Cole, LM Breakwell, ALR Michael, N Chiverton, AK Cross, ... Arthritis research & therapy 16, 1-15, 2014 | 184 | 2014 |
| Potential roles of cytokines and chemokines in human intervertebral disc degeneration: interleukin-1 is a master regulator of catabolic processes KLE Phillips, K Cullen, N Chiverton, ALR Michael, AA Cole, LM Breakwell, ... Osteoarthritis and cartilage 23 (7), 1165-1177, 2015 | 174 | 2015 |
| A preliminary in vitro study into the use of IL‐1Ra gene therapy for the inhibition of intervertebral disc degeneration CL Le Maitre, AJ Freemont, JA Hoyland International journal of experimental pathology 87 (1), 17-28, 2006 | 145 | 2006 |
| Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration KLE Phillips, N Jordan-Mahy, MJH Nicklin, CL Le Maitre Annals of the rheumatic diseases 72 (11), 1860-1867, 2013 | 144 | 2013 |
| An in vitrostudy investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue CL Le Maitre, P Baird, AJ Freemont, JA Hoyland Arthritis research & therapy 11, 1-10, 2009 | 143 | 2009 |
| The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc KLE Phillips, N Chiverton, ALR Michael, AA Cole, LM Breakwell, ... Arthritis research & therapy 15, 1-15, 2013 | 139 | 2013 |
| Human disc degeneration is associated with increased MMP 7 expression CL Le Maitre, AJ Freemont, JA Hoyland Biotechnic & Histochemistry 81 (4-6), 125-131, 2006 | 136 | 2006 |
| Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration H Wang, Y Tian, J Wang, KLE Phillips, ALA Binch, S Dunn, A Cross, ... Journal of Biological Chemistry 288 (23), 16761-16774, 2013 | 125 | 2013 |
