| The art of CHO cell engineering: A comprehensive retrospect and future perspectives S Fischer, R Handrick, K Otte Biotechnology advances 33 (8), 1878-1896, 2015 | 393 | 2015 |
| Unveiling the principle of microRNA-mediated redundancy in cellular pathway regulation S Fischer, R Handrick, A Aschrafi, K Otte RNA biology 12 (3), 238-247, 2015 | 88 | 2015 |
| A functional high‐content miRNA screen identifies miR‐30 family to boost recombinant protein production in CHO cells S Fischer, T Buck, A Wagner, C Ehrhart, J Giancaterino, S Mang, M Schad, ... Biotechnology journal 9 (10), 1279-1292, 2014 | 85 | 2014 |
| miRNA engineering of CHO cells facilitates production of difficult‐to‐express proteins and increases success in cell line development S Fischer, KF Marquart, LA Pieper, J Fieder, M Gamer, I Gorr, P Schulz, ... Biotechnology and Bioengineering 114 (7), 1495-1510, 2017 | 67 | 2017 |
| miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells M Flum, M Kleemann, H Schneider, B Weis, S Fischer, R Handrick, K Otte Journal of cell communication and signaling 12, 451-466, 2018 | 65 | 2018 |
| Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology L Stepper, FA Filser, S Fischer, J Schaub, I Gorr, R Voges Bioprocess and Biosystems Engineering 43, 1431-1443, 2020 | 60 | 2020 |
| miR‐2861 as novel HDAC5 inhibitor in CHO cells enhances productivity while maintaining product quality S Fischer, AJ Paul, A Wagner, S Mathias, M Geiss, F Schandock, ... Biotechnology and bioengineering 112 (10), 2142-2153, 2015 | 59 | 2015 |
| GATA4 is a key regulator of steroidogenesis and glycolysis in mouse Leydig cells A Schrade, A Kyrönlahti, O Akinrinade, M Pihlajoki, M Häkkinen, S Fischer, ... Endocrinology 156 (5), 1860-1872, 2015 | 57 | 2015 |
| GATA4 regulates blood-testis barrier function and lactate metabolism in mouse Sertoli cells A Schrade, A Kyrönlahti, O Akinrinade, M Pihlajoki, S Fischer, ... Endocrinology 157 (6), 2416-2431, 2016 | 56 | 2016 |
| Unraveling what makes a monoclonal antibody difficult‐to‐express: From intracellular accumulation to incomplete folding and degradation via ERAD S Mathias, A Wippermann, N Raab, N Zeh, R Handrick, I Gorr, P Schulz, ... Biotechnology and Bioengineering 117 (1), 5-16, 2020 | 53 | 2020 |
| Transient recombinant protein expression in a human amniocyte cell line: The CAP‐T® cell system S Fischer, N Charara, A Gerber, J Wölfel, G Schiedner, B Voedisch, ... Biotechnology and bioengineering 109 (9), 2250-2261, 2012 | 52 | 2012 |
| CRISPR/Cas9‐mediated knockout of microRNA‐744 improves antibody titer of CHO production cell lines N Raab, S Mathias, K Alt, R Handrick, S Fischer, V Schmieder, V Jadhav, ... Biotechnology Journal 14 (5), 1800477, 2019 | 50 | 2019 |
| Breaking limitations of complex culture media: functional non-viral miRNA delivery into pharmaceutical production cell lines S Fischer, A Wagner, A Kos, A Aschrafi, R Handrick, J Hannemann, K Otte Journal of biotechnology 168 (4), 589-600, 2013 | 49 | 2013 |
| Enhanced protein production by microRNA-30 family in CHO cells is mediated by the modulation of the ubiquitin pathway S Fischer, S Mathias, S Schaz, VV Emmerling, T Buck, M Kleemann, ... Journal of biotechnology 212, 32-43, 2015 | 44 | 2015 |
| Temperature‐sensitive miR‐483 is a conserved regulator of recombinant protein and viral vector production in mammalian cells VV Emmerling, S Fischer, F Stiefel, K Holzmann, R Handrick, F Hesse, ... Biotechnology and bioengineering 113 (4), 830-841, 2016 | 43 | 2016 |
| Visualisation of intracellular production bottlenecks in suspension-adapted CHO cells producing complex biopharmaceuticals using fluorescence microscopy S Mathias, S Fischer, R Handrick, J Fieder, P Schulz, H Bradl, I Gorr, ... Journal of biotechnology 271, 47-55, 2018 | 39 | 2018 |
| Induction of apoptosis in ovarian cancer cells by miR-493-3p directly targeting AKT2, STK38L, HMGA2, ETS1 and E2F5 M Kleemann, H Schneider, K Unger, J Bereuther, S Fischer, P Sander, ... Cellular and Molecular Life Sciences 76, 539-559, 2019 | 38 | 2019 |
| miRNA profiling of high, low and non-producing CHO cells during biphasic fed-batch cultivation reveals process relevant targets for host cell engineering F Stiefel, S Fischer, A Sczyrba, K Otte, F Hesse Journal of Biotechnology 225, 31-43, 2016 | 31 | 2016 |
| Towards maximum acceleration of monoclonal antibody development: Leveraging transposase-mediated cell line generation to enable GMP manufacturing within 3 months using a stable … V Schmieder, J Fieder, R Drerup, EA Gutierrez, C Guelch, J Stolzenberger, ... Journal of biotechnology 349, 53-64, 2022 | 28 | 2022 |
| miR‐143 targets MAPK7 in CHO cells and induces a hyperproductive phenotype to enhance production of difficult‐to‐express proteins M Schoellhorn, S Fischer, A Wagner, R Handrick, K Otte Biotechnology Progress 33 (4), 1046-1058, 2017 | 27 | 2017 |
