Alessio Ciulli

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	Toate	Din 2020
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Andrea TestaTRIMTECH THERAPEUTICSAdresă de e-mail confirmată pe trimtechtherapeutics.com
Scott J. HughesUniversity of DundeeAdresă de e-mail confirmată pe dundee.ac.uk
Chiara ManiaciUniversity of DundeeAdresă de e-mail confirmată pe dundee.ac.uk
Tom L BlundellEmeritus Professor of Biochemistry, University of CambridgeAdresă de e-mail confirmată pe cam.ac.uk
Xavier LucasComputational medicinal chemist at Monte Rosa Therapeutics, BaselAdresă de e-mail confirmată pe monterosatx.com
Dennis BuckleyNIBRAdresă de e-mail confirmată pe novartis.com
Craig CrewsYale UniversityAdresă de e-mail confirmată pe yale.edu
William L. JorgensenSterling Professor of Chemistry, Yale UniversityAdresă de e-mail confirmată pe yale.edu
Sonia RochaDepartment of Biochemistry, Cell and Systems Biology, ISMIB, University of LiverpoolAdresă de e-mail confirmată pe liverpool.ac.uk
William FarnabyUniversity of DundeeAdresă de e-mail confirmată pe dundee.ac.uk
Carles GaldeanoSerra Hunter Lecturer Professor at University of BarcelonaAdresă de e-mail confirmată pe ub.edu
Danette DanielsGroup Leader, Promega CorporationAdresă de e-mail confirmată pe promega.com
Dario AlessiMRC Protein Phosphorylation and Ubiquitylation Units, University of DundeeAdresă de e-mail confirmată pe dundee.ac.uk
Matthias BaudUniversity of SouthamptonAdresă de e-mail confirmată pe soton.ac.uk
Prof. Alison G. SmithDept of Plant Sciences, University of CambridgeAdresă de e-mail confirmată pe cam.ac.uk
Panagis FilippakopoulosAssociate Professor, Oxford UniversityAdresă de e-mail confirmată pe sgc.ox.ac.uk
Fleur M. FergusonUniversity of California, San DiegoAdresă de e-mail confirmată pe ucsd.edu
Oleg FedorovUniversity of OxfordAdresă de e-mail confirmată pe cmd.ox.ac.uk
Dr Ola EpemoluPrincipal Research Scientist in In vitro/In vivo DMPK -CRLAdresă de e-mail confirmată pe crl.com
Georg E WinterPrincipal Investigator at CeMM, ViennaAdresă de e-mail confirmată pe cemm.oeaw.ac.at

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Alessio Ciulli

Professor, University of Dundee

Adresă de e-mail confirmată pe dundee.ac.uk - Pagina de pornire

Chemical Biology Structural Biology Medicinal Chemistry Drug Discovery Targeted Protein Degradation


Titlu Sortați după descrierea bibliografică Sortați după an Sortați după titlu	Citat de Citat de	Anul
Structural basis of PROTAC cooperative recognition for selective protein degradation MS Gadd, A Testa, X Lucas, KH Chan, W Chen, DJ Lamont, M Zengerle, ... Nature chemical biology 13 (5), 514-521, 2017	1106	2017
Selective small molecule induced degradation of the BET bromodomain protein BRD4 M Zengerle, KH Chan, A Ciulli ACS chemical biology 10 (8), 1770-1777, 2015	1054	2015
Targeting the von Hippel–Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction DL Buckley, I Van Molle, PC Gareiss, HS Tae, J Michel, DJ Noblin, ... Journal of the American Chemical Society 134 (10), 4465-4468, 2012	595	2012
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design W Farnaby, M Koegl, MJ Roy, C Whitworth, E Diers, N Trainor, D Zollman, ... Nature chemical biology 15 (7), 672-680, 2019	496	2019
Structure-guided design and optimization of small molecules targeting the protein–protein interaction between the von Hippel–Lindau (VHL) E3 ubiquitin ligase and the hypoxia … C Galdeano, MS Gadd, P Soares, S Scaffidi, I Van Molle, I Birced, ... Journal of Medicinal Chemistry 57 (20), 8657-8663, 2014	443	2014
Small Molecule Inhibitors of the Interaction Between the E3 Ligase VHL and HIF1α DL Buckley, JL Gustafson, I Van Molle, AG Roth, HS Tae, PC Gareiss, ... Angewandte Chemie (International Ed. in English) 51 (46), 11463, 2012	353	2012
Iterative design and optimization of initially inactive proteolysis targeting chimeras (PROTACs) identify VZ185 as a potent, fast, and selective von Hippel–Lindau (VHL) based … V Zoppi, SJ Hughes, C Maniaci, A Testa, T Gmaschitz, C Wieshofer, ... Journal of medicinal chemistry 62 (2), 699-726, 2018	315	2018
SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate MJ Roy, S Winkler, SJ Hughes, C Whitworth, M Galant, W Farnaby, ... ACS chemical biology 14 (3), 361-368, 2019	296	2019
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation C Maniaci, SJ Hughes, A Testa, W Chen, DJ Lamont, S Rocha, DR Alessi, ... Nature communications 8 (1), 830, 2017	284	2017
E3 ligase ligands for PROTACs: how they were found and how to discover new ones T Ishida, A Ciulli SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (4), 484-502, 2021	269	2021
Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation E Bulatov, A Ciulli Biochemical Journal 467 (3), 365-386, 2015	241	2015
Impact of target warhead and linkage vector on inducing protein degradation: comparison of bromodomain and extra-terminal (BET) degraders derived from triazolodiazepine (JQ1 … KH Chan, M Zengerle, A Testa, A Ciulli Journal of medicinal chemistry 61 (2), 504-513, 2018	230	2018
Dissecting fragment-based lead discovery at the von Hippel-Lindau protein: hypoxia inducible factor 1α protein-protein interface I Van Molle, A Thomann, DL Buckley, EC So, S Lang, CM Crews, A Ciulli Chemistry & biology 19 (10), 1300-1312, 2012	229	2012
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition J Frost, C Galdeano, P Soares, MS Gadd, KM Grzes, L Ellis, O Epemolu, ... Nature communications 7 (1), 13312, 2016	228	2016
Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders SJ Hughes, A Ciulli Essays in biochemistry 61 (5), 505-516, 2017	222	2017
Structure‐based design of a macrocyclic PROTAC A Testa, SJ Hughes, X Lucas, JE Wright, A Ciulli Angewandte Chemie International Edition 59 (4), 1727-1734, 2020	209	2020
Cyclic and macrocyclic peptides as chemical tools to recognise protein surfaces and probe protein–protein interactions TAF Cardote, A Ciulli ChemMedChem 11 (8), 787-794, 2016	193	2016
Application of Fragment Growing and Fragment Linking to the Discovery of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase This research was supported by the … AW Hung, HL Silvestre, S Wen, A Ciulli, TL Blundell, C Abell Angewandte Chemie-German Edition 121 (45), 8604, 2009	187	2009
Probing hot spots at Protein− Ligand binding sites: A fragment-based approach using biophysical methods A Ciulli, G Williams, AG Smith, TL Blundell, C Abell Journal of medicinal chemistry 49 (16), 4992-5000, 2006	177	2006
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity S Imaide, KM Riching, N Makukhin, V Vetma, C Whitworth, SJ Hughes, ... Nature chemical biology 17 (11), 1157–1167, 2021	176	2021

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