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Ortwin Naujok
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Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors
O Naujok, J Lentes, U Diekmann, C Davenport, S Lenzen
BMC research notes 7, 1-8, 2014
1392014
The generation of definitive endoderm from human embryonic stem cells is initially independent from activin A but requires canonical Wnt-signaling
O Naujok, U Diekmann, S Lenzen
Stem Cell Reviews and Reports 10, 480-493, 2014
802014
Anterior–posterior patterning of definitive endoderm generated from human embryonic stem cells depends on the differential signaling of retinoic acid, Wnt-, and BMP-signaling
C Davenport, U Diekmann, I Budde, N Detering, O Naujok
Stem Cells 34 (11), 2635-2647, 2016
752016
Reversal of diabetes through gene therapy of diabetic rats by hepatic insulin expression via lentiviral transduction
M Elsner, T Terbish, A Jörns, O Naujok, D Wedekind, HJ Hedrich, ...
Molecular Therapy 20 (5), 918-926, 2012
652012
Insulin-producing surrogate β-cells from embryonic stem cells: are we there yet?
O Naujok, C Burns, PM Jones, S Lenzen
Molecular Therapy 19 (10), 1759-1768, 2011
622011
40th EASD Annual Meeting of the European Association for the Study of Diabetes: Munich, Germany, 5–9 September 2004
M Veitenhansl, K Stegner, FX Hierl, C Dieterle, H Feldmeier, B Gutt, ...
Diabetologia 47, A1-A464, 2004
562004
Overexpression of the antioxidant enzyme catalase does not interfere with the glucose responsiveness of insulin-secreting INS-1E cells and rat islets
S Lortz, E Gurgul-Convey, O Naujok, S Lenzen
Diabetologia 56, 774-782, 2013
512013
Selective removal of undifferentiated embryonic stem cells from differentiation cultures through HSV1 thymidine kinase and ganciclovir treatment
O Naujok, J Kaldrack, T Taivankhuu, A Jörns, S Lenzen
Stem cell reviews and reports 6, 450-461, 2010
492010
Changes in gene expression and morphology of mouse embryonic stem cells on differentiation into insulin‐producing cells in vitro and in vivo
O Naujok, F Francini, S Picton, CJ Bailey, S Lenzen, A Jörns
Diabetes/metabolism research and reviews 25 (5), 464-476, 2009
362009
A reliable and efficient protocol for human pluripotent stem cell differentiation into the definitive endoderm based on dispersed single cells
U Diekmann, S Lenzen, O Naujok
Stem cells and development 24 (2), 190-204, 2015
342015
A new experimental protocol for preferential differentiation of mouse embryonic stem cells into insulin-producing cells
O Naujok, F Francini, S Picton, A Jörns, CJ Bailey, S Lenzen
Cell transplantation 17 (10-11), 1231-1242, 2008
312008
miRNome profiling of purified endoderm and mesoderm differentiated from hESCs reveals functions of miR-483-3p and miR-1263 for cell-fate decisions
D Ishikawa, U Diekmann, J Fiedler, A Just, T Thum, S Lenzen, O Naujok
Stem cell reports 9 (5), 1588-1603, 2017
262017
An efficient experimental strategy for mouse embryonic stem cell differentiation and separation of a cytokeratin‐19‐positive population of insulin‐producing cells
O Naujok, F Francini, A Jörns, S Lenzen
Cell Proliferation 41 (4), 607-624, 2008
252008
Chemically-defined, xeno-free, scalable production of hPSC-derived definitive endoderm aggregates with multi-lineage differentiation potential
A Sahabian, M Sgodda, O Naujok, R Dettmer, J Dahlmann, F Manstein, ...
Cells 8 (12), 1571, 2019
242019
A critical re-evaluation of CD24-positivity of human embryonic stem cells differentiated into pancreatic progenitors
O Naujok, S Lenzen
Stem Cell Reviews and Reports 8, 779-791, 2012
242012
Coaxial alginate hydrogels: from self-assembled 3D cellular constructs to long-term storage
O Gryshkov, V Mutsenko, D Tarusin, D Khayyat, O Naujok, E Riabchenko, ...
International journal of molecular sciences 22 (6), 3096, 2021
232021
FGF2 inhibits early pancreatic lineage specification during differentiation of human embryonic stem cells
R Dettmer, K Cirksena, J Münchhoff, J Kresse, U Diekmann, I Niwolik, ...
Cells 9 (9), 1927, 2020
202020
Proinflammatory cytokines induce rapid, NO-independent apoptosis, expression of chemotactic mediators and interleukin-32 secretion in human pluripotent stem cell-derived beta cells
R Dettmer, I Niwolik, K Cirksena, T Yoshimoto, Y Tang, I Mehmeti, ...
Diabetologia 65 (5), 829-843, 2022
192022
Chemically defined and xenogeneic-free differentiation of human pluripotent stem cells into definitive endoderm in 3D culture
U Diekmann, H Wolling, R Dettmer, I Niwolik, O Naujok, FFR Buettner
Scientific Reports 9 (1), 996, 2019
192019
Embryonic stem cells of the non‐human primate Callithrix jacchus can be differentiated into definitive endoderm by Activin‐A but not IDE‐1/2
U Diekmann, O Naujok, R Blasczyk, T Müller
Journal of tissue engineering and regenerative medicine 9 (4), 473-479, 2015
162015
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