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Ake Tzu-Hui Lu
Ake Tzu-Hui Lu
Senior Scientist, Computational, San Diego Institute of Science, Altos Labs
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An epigenetic biomarker of aging for lifespan and healthspan
ME Levine, AT Lu, A Quach, BH Chen, TL Assimes, S Bandinelli, L Hou, ...
Aging (albany NY) 10 (4), 573, 2018
24942018
DNA methylation GrimAge strongly predicts lifespan and healthspan
AT Lu, A Quach, JG Wilson, AP Reiner, A Aviv, K Raj, L Hou, ...
Aging (albany NY) 11 (2), 303, 2019
17732019
DNA methylation-based measures of biological age: meta-analysis predicting time to death
BH Chen, RE Marioni, E Colicino, MJ Peters, CK Ward-Caviness, PC Tsai, ...
Aging (Albany NY) 8 (9), 1844, 2016
10712016
Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography
O Tan, V Chopra, ATH Lu, JS Schuman, H Ishikawa, G Wollstein, ...
Ophthalmology 116 (12), 2305-2314. e2, 2009
8802009
An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease
S Horvath, M Gurven, ME Levine, BC Trumble, H Kaplan, H Allayee, ...
Genome biology 17, 1-23, 2016
7282016
Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
A Quach, ME Levine, T Tanaka, AT Lu, BH Chen, L Ferrucci, B Ritz, ...
Aging (albany NY) 9 (2), 419, 2017
7232017
Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
S Horvath, J Oshima, GM Martin, AT Lu, A Quach, H Cohen, S Felton, ...
Aging (Albany NY) 10 (7), 1758, 2018
5942018
Mapping of macular substructures with optical coherence tomography for glaucoma diagnosis
O Tan, G Li, ATH Lu, R Varma, D Huang, ...
Ophthalmology 115 (6), 949-956, 2008
5252008
Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning
ME Levine, AT Lu, DA Bennett, S Horvath
Aging (Albany NY) 7 (12), 1198, 2015
4862015
Menopause accelerates biological aging
ME Levine, AT Lu, BH Chen, DG Hernandez, AB Singleton, L Ferrucci, ...
Proceedings of the National Academy of Sciences 113 (33), 9327-9332, 2016
4832016
GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality
C McCrory, G Fiorito, B Hernandez, S Polidoro, AM O’Halloran, A Hever, ...
The Journals of Gerontology: Series A 76 (5), 741-749, 2021
3402021
DNA methylation-based estimator of telomere length
AT Lu, A Seeboth, PC Tsai, D Sun, A Quach, AP Reiner, C Kooperberg, ...
Aging (Albany NY) 11 (16), 5895, 2019
3162019
Keratoconus diagnosis with optical coherence tomography pachymetry mapping
Y Li, DM Meisler, M Tang, ATH Lu, V Thakrar, BJ Reiser, D Huang
Ophthalmology 115 (12), 2159-2166, 2008
3122008
The cerebellum ages slowly according to the epigenetic clock
S Horvath, V Mah, AT Lu, JS Woo, OW Choi, AJ Jasinska, JA Riancho, ...
Aging (Albany NY) 7 (5), 294, 2015
2152015
Universal DNA methylation age across mammalian tissues
AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li, R Lowe, Q Yan, ...
Nature aging 3 (9), 1144-1166, 2023
1972023
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
DL McCartney, JL Min, RC Richmond, AT Lu, MK Sobczyk, G Davies, ...
Genome biology 22, 1-25, 2021
1882021
GWAS of epigenetic aging rates in blood reveals a critical role for TERT
AT Lu, L Xue, EL Salfati, BH Chen, L Ferrucci, D Levy, R Joehanes, ...
Nature communications 9 (1), 387, 2018
1772018
A mammalian methylation array for profiling methylation levels at conserved sequences
A Arneson, A Haghani, MJ Thompson, M Pellegrini, SB Kwon, H Vu, ...
Nature communications 13 (1), 783, 2022
1742022
A quantitative trait locus analysis of social responsiveness in multiplex autism families
JA Duvall, A Lu, RM Cantor, RD Todd, JN Constantino, DH Geschwind
American Journal of Psychiatry 164 (4), 656-662, 2007
1722007
Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography
Y Wang, A Lu, J Gil-Flamer, O Tan, JA Izatt, D Huang
British Journal of Ophthalmology 93 (5), 634-637, 2009
1532009
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