Robert J Young

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	Toate	Din 2020
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Rob FieldPVC Science, UEA and Iceni GlycoscienceAdresă de e-mail confirmată pe uea.ac.uk
Paul LeesonPaul Leeson Consulting LtdAdresă de e-mail confirmată pe nottingham.ac.uk
Julia Castro-PichelAdresă de e-mail confirmată pe gsk.com
Matt CampbellCharles River LaboratoriesAdresă de e-mail confirmată pe crl.com
David O'HaganUniversity of St AndrewsAdresă de e-mail confirmată pe st-andrews.ac.uk
György M. KeserűHungarian Academy of SciencesAdresă de e-mail confirmată pe ttk.mta.hu
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Stanislav GobecFaculty of Pharmacy, University of LjubljanaAdresă de e-mail confirmată pe ffa.uni-lj.si
Izidor SosičResearch Scientist, Faculty of Pharmacy, University of LjubljanaAdresă de e-mail confirmată pe ffa.uni-lj.si
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Andrew LeachHead of Chemical Biology, European Bioinformatics InstituteAdresă de e-mail confirmată pe ebi.ac.uk
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Ronald J QuinnGriffith UniversityAdresă de e-mail confirmată pe griffith.edu.au
NJ TurnerProfessor of Chemical Biology, Manchester UniversityAdresă de e-mail confirmată pe manchester.ac.uk
John G. Cumming, PhDExperienced medicinal chemist, AstraZeneca PharmaceuticalsAdresă de e-mail confirmată pe astrazeneca.com
Gurdyal BesraBardrick Professor of Microbial Physiology & ChemistryAdresă de e-mail confirmată pe bham.ac.uk

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Robert J Young

Blue Burgundy Consulting

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Medicinal Chemistry Drug Discovery Property Based Design


Titlu Sortați după descrierea bibliografică Sortați după an Sortați după titlu	Citat de Citat de	Anul
Expanding the medicinal chemistry synthetic toolbox J Boström, DG Brown, RJ Young, GM Keserü Nature Reviews Drug Discovery 17 (10), 709-727, 2018	645	2018
The impact of aromatic ring count on compound developability: further insights by examining carbo-and hetero-aromatic and-aliphatic ring types TJ Ritchie, SJF Macdonald, RJ Young, SD Pickett Drug discovery today 16 (3-4), 164-171, 2011	434	2011
Fueling open‐source drug discovery: 177 small‐molecule leads against tuberculosis L Ballell, RH Bates, RJ Young, D Alvarez‐Gomez, E Alvarez‐Ruiz, ... ChemMedChem 8 (2), 313-321, 2013	373	2013
Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity RJ Young, DVS Green, CN Luscombe, AP Hill Drug discovery today 16 (17-18), 822-830, 2011	350	2011
Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity AP Hill, RJ Young Drug discovery today 15 (15-16), 648-655, 2010	309	2010
New small-molecule synthetic antimycobacterials L Ballell, RA Field, K Duncan, RJ Young Antimicrobial agents and chemotherapy 49 (6), 2153-2163, 2005	252	2005
New thiopyrazolo [3, 4-d] pyrimidine derivatives as anti-mycobacterial agents L Ballell, RA Field, GAC Chung, RJ Young Bioorganic & medicinal chemistry letters 17 (6), 1736-1740, 2007	157	2007
Molecular property design: does everyone get it? PD Leeson, RJ Young ACS medicinal chemistry letters 6 (7), 722-725, 2015	153	2015
An Electrostatic Gauche Effect in β‐Fluoro‐ and β‐Hydroxy‐N‐ethylpyridinium Cations NEJ Gooseman, D O'Hagan, MJG Peach, AMZ Slawin, DJ Tozer, ... Angewandte Chemie International Edition 46 (31), 5904-5908, 2007	114	2007
Mapping the efficiency and physicochemical trajectories of successful optimizations RJ Young, PD Leeson Journal of medicinal chemistry 61 (15), 6421-6467, 2018	110	2018
Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine RJ Young, RM Beams, K Carter, HAR Clark, DM Coe, CL Chambers, ... Bioorganic & medicinal chemistry letters 10 (6), 597-600, 2000	106	2000
Facts, Patterns and Principles in Drug Discovery: appraising the Rule of 5 with measured physicochemical data. CP Tinworth, RJ Young Journal of Medicinal Chemistry, 2020	98	2020
Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis R Šink, I Sosič, M Živec, R Fernandez-Menendez, S Turk, S Pajk, ... Journal of medicinal chemistry 58 (2), 613-624, 2015	84	2015
The Time and Place for Nature in Drug Discovery RJ Young, SL Flitsch, M Grigalunas, PD Leeson, RJ Quinn, NJ Turner, ... JACS Au 2 (11), 2400-2416, 2022	76	2022
Application of Biocatalysis to on‐DNA Carbohydrate Library Synthesis B Thomas, X Lu, WR Birmingham, K Huang, P Both, JE Reyes Martinez, ... ChemBioChem 18 (9), 858-863, 2017	74	2017
Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase SM Batt, M Cacho Izquierdo, J Castro Pichel, CJ Stubbs, ... ACS Infectious Diseases 1 (12), 615-626, 2015	71	2015
Synthesis and antiviral evaluation of enantiomeric 2′, 3′-dideoxy-and 2′, 3′-didehydro-2′, 3′-dideoxy-4′-thionucleosides RJ Young, S Shaw-Ponter, JB Thomson, JA Miller, JG Cumming, ... Bioorganic & Medicinal Chemistry Letters 5 (22), 2599-2604, 1995	71	1995
A new ‘golden age’for the antitubercular target InhA K Rožman, I Sosič, R Fernandez, RJ Young, A Mendoza, S Gobec, ... Drug discovery today 22 (3), 492-502, 2017	70	2017
Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl} sulfonamides C Chan, AD Borthwick, D Brown, CL Burns-Kurtis, M Campbell, ... Journal of medicinal chemistry 50 (7), 1546-1557, 2007	57	2007
Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery MJ Rebollo-Lopez, J Lelièvre, D Alvarez-Gomez, J Castro-Pichel, ... PloS one 10 (12), e0142293, 2015	50	2015

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