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Laura Greaves
Laura Greaves
Research Fellow, Newcastle University
Adresă de e-mail confirmată pe ncl.ac.uk - Pagina de pornire
Titlu
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Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
D Jurk, C Wilson, JF Passos, F Oakley, C Correia-Melo, L Greaves, ...
Nature communications 5 (1), 4172, 2014
8332014
Mitochondria are required for pro‐ageing features of the senescent phenotype
C Correia‐Melo, FDM Marques, R Anderson, G Hewitt, R Hewitt, J Cole, ...
The EMBO journal 35 (7), 724-742, 2016
7242016
Mitochondrial DNA mutations in human colonic crypt stem cells
RW Taylor, MJ Barron, GM Borthwick, A Gospel, PF Chinnery, ...
The Journal of clinical investigation 112 (9), 1351-1360, 2003
6392003
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
R Anderson, A Lagnado, D Maggiorani, A Walaszczyk, E Dookun, ...
The EMBO journal 38 (5), e100492, 2019
4692019
Mitochondrial DNA and disease
LC Greaves, AK Reeve, RW Taylor, DM Turnbull
The Journal of pathology 226 (2), 274-286, 2012
4032012
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission
LC Greaves, SL Preston, PJ Tadrous, RW Taylor, MJ Barron, D Oukrif, ...
Proceedings of the National Academy of Sciences 103 (3), 714-719, 2006
3422006
Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells
SAC McDonald, LC Greaves, L Gutierrez–Gonzalez, M Rodriguez–Justo, ...
Gastroenterology 134 (2), 500-510, 2008
2952008
Apoptotic stress causes mtDNA release during senescence and drives the SASP
S Victorelli, H Salmonowicz, J Chapman, H Martini, MG Vizioli, JS Riley, ...
Nature 622 (7983), 627-636, 2023
2442023
Locating the stem cell niche and tracing hepatocyte lineages in human liver
TG Fellous, S Islam, PJ Tadrous, G Elia, HM Kocher, S Bhattacharya, ...
Hepatology 49 (5), 1655-1663, 2009
1982009
Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing
LC Greaves, M Nooteboom, JL Elson, HAL Tuppen, GA Taylor, ...
PLoS genetics 10 (9), e1004620, 2014
1732014
The rise and rise of mitochondrial DNA mutations
C Lawless, L Greaves, AK Reeve, DM Turnbull, AE Vincent
Open biology 10 (5), 200061, 2020
1432020
Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies
SC Wilkinson, WJM Maas, JB Nielsen, LC Greaves, JJM van de Sandt, ...
International archives of occupational and environmental health 79, 405-413, 2006
1342006
A phenotype-driven approach to generate mouse models with pathogenic mtDNA mutations causing mitochondrial disease
JHK Kauppila, HL Baines, A Bratic, ML Simard, C Freyer, A Mourier, ...
Cell reports 16 (11), 2980-2990, 2016
1322016
The ageing mitochondrial genome
KJ Krishnan, LC Greaves, AK Reeve, D Turnbull
Nucleic acids research 35 (22), 7399-7405, 2007
1092007
Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis
ALM Smith, JC Whitehall, C Bradshaw, D Gay, F Robertson, AP Blain, ...
Nature cancer 1 (10), 976-989, 2020
1082020
A bioreactor technology for modeling fibrosis in human and rodent precision‐cut liver slices
HL Paish, LH Reed, H Brown, MC Bryan, O Govaere, J Leslie, BS Barksby, ...
Hepatology 70 (4), 1377-1391, 2019
1052019
Quantification of mitochondrial DNA mutation load
LC Greaves, NE Beadle, GA Taylor, D Commane, JC Mathers, K Khrapko, ...
Aging cell 8 (5), 566-572, 2009
1032009
A methodological approach to tracing cell lineage in human epithelial tissues
TG Fellous, SAC McDonald, J Burkert, A Humphries, S Islam, ...
Stem Cells 27 (6), 1410-1420, 2009
912009
Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss
PF Dobson, EP Dennis, D Hipps, A Reeve, A Laude, C Bradshaw, ...
Scientific reports 10 (1), 11643, 2020
882020
Mitochondrial DNA mutations and aging
KJ Krishnan, LC Greaves, AK Reeve, DM Turnbull
Annals of the New York Academy of Sciences 1100 (1), 227-240, 2007
882007
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