| SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase Q Zheng, JL Woehl, S Kitamura, D Santos-Martins, CJ Smedley, G Li, ... Proceedings of the National Academy of Sciences 116 (38), 18808-18814, 2019 | 171 | 2019 |
| Sulfur (VI) fluoride exchange (SuFEx)-enabled high-throughput medicinal chemistry S Kitamura, Q Zheng, JL Woehl, A Solania, E Chen, N Dillon, MV Hull, ... Journal of the American Chemical Society 142 (25), 10899-10904, 2020 | 145 | 2020 |
| Diversity oriented clicking (DOC): divergent synthesis of SuFExable pharmacophores from 2‐substituted‐alkynyl‐1‐sulfonyl fluoride (SASF) hubs CJ Smedley, G Li, AS Barrow, TL Gialelis, MC Giel, A Ottonello, Y Cheng, ... Angewandte Chemie 132 (30), 12560-12569, 2020 | 113 | 2020 |
| Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria EN Bess, JE Bisanz, F Yarza, A Bustion, BE Rich, X Li, S Kitamura, ... Nature microbiology 5 (1), 56-66, 2020 | 96 | 2020 |
| Chemical inhibition of ENL/AF9 YEATS domains in acute leukemia L Garnar-Wortzel, TR Bishop, S Kitamura, N Milosevich, JN Asiaban, ... ACS central science 7 (5), 815-830, 2021 | 69 | 2021 |
| Discovery of small-molecule enzyme activators by activity-based protein profiling BP Kok, S Ghimire, W Kim, S Chatterjee, T Johns, S Kitamura, J Eberhardt, ... Nature chemical biology 16 (9), 997-1005, 2020 | 43 | 2020 |
| Lipoprotein signal peptidase inhibitors with antibiotic properties identified through design of a robust in vitro HT platform S Kitamura, A Owensby, D Wall, DW Wolan Cell chemical biology 25 (3), 301-308. e12, 2018 | 39 | 2018 |
| An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen Y Yao, RU Kadam, CCD Lee, JL Woehl, NC Wu, X Zhu, S Kitamura, ... Proceedings of the National Academy of Sciences 117 (31), 18431-18438, 2020 | 38 | 2020 |
| Potent Natural Soluble Epoxide Hydrolase Inhibitors from Pentadiplandra brazzeana Baillon: Synthesis, Quantification, and Measurement of Biological Activities In Vitro and … S Kitamura, C Morisseau, B Inceoglu, SG Kamita, GR De Nicola, ... PLoS One 10 (2), e0117438, 2015 | 29 | 2015 |
| Metabolomics activity screening of T cell–induced colitis reveals anti-inflammatory metabolites JR Montenegro-Burke, BP Kok, C Guijas, X Domingo-Almenara, C Moon, ... Science signaling 14 (702), eabf6584, 2021 | 27 | 2021 |
| Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa S Kitamura, KL Hvorecny, J Niu, BD Hammock, DR Madden, C Morisseau Journal of medicinal chemistry 59 (10), 4790-4799, 2016 | 27 | 2016 |
| Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors Y Cheng, G Li, CJ Smedley, MC Giel, S Kitamura, JL Woehl, G Bianco, ... Proceedings of the National Academy of Sciences 119 (37), e2208540119, 2022 | 22 | 2022 |
| Structural requirement and stereospecificity of tetrahydroquinolines as potent ecdysone agonists S Kitamura, T Harada, H Hiramatsu, R Shimizu, H Miyagawa, ... Bioorganic & medicinal chemistry letters 24 (7), 1715-1718, 2014 | 21 | 2014 |
| Synthetic elaboration of native DNA by RASS (SenDr) DT Flood, KW Knouse, JC Vantourout, S Kitamura, BB Sanchez, ... ACS Central Science 6 (10), 1789-1799, 2020 | 19 | 2020 |
| Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif) N Vasylieva, S Kitamura, J Dong, B Barnych, KL Hvorecny, DR Madden, ... Analytica chimica acta 1057, 106-113, 2019 | 18 | 2019 |
| Active-site flexibility and substrate specificity in a bacterial virulence factor: crystallographic snapshots of an epoxide hydrolase KL Hvorecny, CD Bahl, S Kitamura, KSS Lee, BD Hammock, C Morisseau, ... Structure 25 (5), 697-707. e4, 2017 | 17 | 2017 |
| Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales S Kitamura, C Morisseau, TR Harris, B Inceoglu, BD Hammock PloS one 12 (5), e0176571, 2017 | 15 | 2017 |
| An Irreversible Inhibitor to Probe the Role of Streptococcus pyogenes Cysteine Protease SpeB in Evasion of Host Complement Defenses JL Woehl, S Kitamura, N Dillon, Z Han, LJ Edgar, V Nizet, DW Wolan ACS chemical biology 15 (8), 2060-2069, 2020 | 11 | 2020 |
| The genetic basis for the cooperative bioactivation of plant lignans by a human gut bacterial consortium EN Bess, JE Bisanz, P Spanogiannopoulos, QY Ang, A Bustion, ... bioRxiv, 357640, 2018 | 10 | 2018 |
| The development of the bengamides as new antibiotics against drug-resistant bacteria C Porras-Alcalá, F Moya-Utrera, M García-Castro, A Sánchez-Ruiz, ... Marine Drugs 20 (6), 373, 2022 | 9 | 2022 |
Dennis WolanSenior Principal Scientist, GenentechAdresă de e-mail confirmată pe gene.com
