Подписаться
David J Huggins
David J Huggins
Sanders Tri-Institutional Therapeutics Discovery Institute/Weill Cornell Medicine
Подтвержден адрес электронной почты в домене med.cornell.edu - Главная страница
Название
Процитировано
Процитировано
Год
Rational approaches to improving selectivity in drug design
DJ Huggins, W Sherman, B Tidor
Journal of medicinal chemistry 55 (4), 1424-1444, 2012
4112012
Biomolecular simulations: From dynamics and mechanisms to computational assays of biological activity
DJ Huggins, PC Biggin, MA Dämgen, JW Essex, SA Harris, ...
Wiley Interdisciplinary Reviews: Computational Molecular Science 9 (3), e1393, 2019
1712019
Overcoming chemical, biological, and computational challenges in the development of inhibitors targeting protein-protein interactions
L Laraia, G McKenzie, DR Spring, AR Venkitaraman, DJ Huggins
Chemistry & biology 22 (6), 689-703, 2015
1682015
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair
H Khoury-Haddad, N Guttmann-Raviv, I Ipenberg, D Huggins, ...
Proceedings of the National Academy of Sciences 111 (7), E728-E737, 2014
1532014
Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues
N Kastan, K Gnedeva, T Alisch, AA Petelski, DJ Huggins, J Chiaravalli, ...
Nature communications 12 (1), 3100, 2021
1452021
A role for glycine in the gating of plant NMDA‐like receptors
C Dubos, D Huggins, GH Grant, MR Knight, MM Campbell
The Plant Journal 35 (6), 800-810, 2003
1442003
Rational methods for the selection of diverse screening compounds
DJ Huggins, AR Venkitaraman, DR Spring
ACS chemical biology 6 (3), 208-217, 2011
1422011
International union of basic and clinical pharmacology. CVII. Structure and pharmacology of the apelin receptor with a recommendation that elabela/toddler is a second …
C Read, D Nyimanu, TL Williams, DJ Huggins, P Sulentic, RGC Macrae, ...
Pharmacological reviews 71 (4), 467-502, 2019
1102019
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2
M Janeček, M Rossmann, P Sharma, A Emery, DJ Huggins, SR Stockwell, ...
Scientific Reports 6 (1), 28528, 2016
1072016
Quantifying the entropy of binding for water molecules in protein cavities by computing correlations
DJ Huggins
Biophysical journal 108 (4), 928-936, 2015
842015
Correlations in liquid water for the TIP3P-Ewald, TIP4P-2005, TIP5P-Ewald, and SWM4-NDP models
DJ Huggins
The Journal of chemical physics 136 (6), 2012
712012
Characterization and tissue‐specific expression of two lepidopteran farnesyl diphosphate synthase homologs: Implications for the biosynthesis of ethyl‐substituted juvenile hormones
M Cusson, C Béliveau, SE Sen, S Vandermoten, RG Rutledge, D Stewart, ...
Proteins: Structure, function, and bioinformatics 65 (3), 742-758, 2006
682006
The function of the amino terminal domain in NMDA receptor modulation
DJ Huggins, GH Grant
Journal of Molecular Graphics and Modelling 23 (4), 381-388, 2005
672005
Systematic placement of structural water molecules for improved scoring of protein–ligand interactions
DJ Huggins, B Tidor
Protein Engineering, Design & Selection 24 (10), 777-789, 2011
632011
On-demand male contraception via acute inhibition of soluble adenylyl cyclase
M Balbach, T Rossetti, J Ferreira, L Ghanem, C Ritagliati, RW Myers, ...
Nature communications 14 (1), 637, 2023
592023
Thermodynamic properties of water molecules at a protein–protein interaction surface
DJ Huggins, M Marsh, MC Payne
Journal of chemical theory and computation 7 (11), 3514-3522, 2011
582011
Enhancing hit discovery in virtual screening through absolute protein–ligand binding free-energy calculations
W Chen, D Cui, SV Jerome, M Michino, EB Lenselink, DJ Huggins, ...
Journal of Chemical Information and Modeling 63 (10), 3171-3185, 2023
572023
Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells
E Mullarky, J Xu, AD Robin, DJ Huggins, A Jennings, N Noguchi, A Olland, ...
Bioorganic & medicinal chemistry letters 29 (17), 2503-2510, 2019
562019
Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance
MK Parai, DJ Huggins, H Cao, MNL Nalam, A Ali, CA Schiffer, B Tidor, ...
Journal of medicinal chemistry 55 (14), 6328-6341, 2012
552012
Assessing the accuracy of inhomogeneous fluid solvation theory in predicting hydration free energies of simple solutes
DJ Huggins, MC Payne
The Journal of Physical Chemistry B 117 (27), 8232-8244, 2013
482013
В данный момент система не может выполнить эту операцию. Повторите попытку позднее.
Статьи 1–20