| Deuterium in drug discovery: progress, opportunities and challenges RMC Di Martino, BD Maxwell, T Pirali Nature Reviews Drug Discovery 22 (7), 562-584, 2023 | 229 | 2023 |
| Versatility of the curcumin scaffold: discovery of potent and balanced dual BACE-1 and GSK-3β inhibitors RMC Di Martino, A De Simone, V Andrisano, P Bisignano, A Bisi, S Gobbi, ... Journal of medicinal chemistry 59 (2), 531-544, 2016 | 128 | 2016 |
| Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity A Bisi, C Cappadone, A Rampa, G Farruggia, A Sargenti, F Belluti, ... European journal of medicinal chemistry 127, 577-585, 2017 | 96 | 2017 |
| Identification of chalcone-based antileishmanial agents targeting trypanothione reductase M Ortalli, A Ilari, G Colotti, I De Ionna, T Battista, A Bisi, S Gobbi, A Rampa, ... European journal of medicinal chemistry 152, 527-541, 2018 | 78 | 2018 |
| GSK-3β, FYN, and DYRK1A: master regulators in neurodegenerative pathways S Demuro, RMC Di Martino, JA Ortega, A Cavalli International journal of molecular sciences 22 (16), 9098, 2021 | 66 | 2021 |
| Novel curcumin-diethyl fumarate hybrid as a dualistic GSK-3β inhibitor/Nrf2 inducer for the treatment of Parkinson’s disease RMC Di Martino, L Pruccoli, A Bisi, S Gobbi, A Rampa, A Martinez, ... ACS Chemical Neuroscience 11 (17), 2728-2740, 2020 | 45 | 2020 |
| Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: curcumin RMC Di Martino, B Luppi, A Bisi, S Gobbi, A Rampa, A Abruzzo, F Belluti Expert Opinion on Therapeutic Patents 27 (5), 579-590, 2017 | 44 | 2017 |
| Investigating drug–target residence time in kinases through enhanced sampling simulations D Gobbo, V Piretti, RMC Di Martino, SK Tripathi, B Giabbai, P Storici, ... Journal of Chemical Theory and Computation 15 (8), 4646-4659, 2019 | 41 | 2019 |
| Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration RMC Di Martino, A Bisi, A Rampa, S Gobbi, F Belluti Expert Opinion on Therapeutic Patents 27 (8), 953-965, 2017 | 38 | 2017 |
| From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold A Rampa, F Mancini, A De Simone, F Falchi, F Belluti, RMC Di Martino, ... Bioorganic & Medicinal Chemistry Letters 25 (14), 2804-2808, 2015 | 38 | 2015 |
| A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs IP Bhela, A Ranza, FC Balestrero, M Serafini, S Aprile, RMCD Martino, ... Journal of Medicinal Chemistry 65 (22), 15282–15299, 2022 | 37 | 2022 |
| Design, synthesis, structure–activity relationship studies, and three-dimensional quantitative structure–activity relationship (3D-QSAR) modeling of a series of o-biphenyl … A De Simone, D Russo, GF Ruda, A Micoli, M Ferraro, RMC Di Martino, ... Journal of medicinal chemistry 60 (6), 2287-2304, 2017 | 35 | 2017 |
| Phenolic 1, 3‐diketones attenuate lipopolysaccharide‐induced inflammatory response by an alternative magnesium‐mediated mechanism M Zusso, G Mercanti, F Belluti, RMC Di Martino, A Pagetta, C Marinelli, ... British Journal of Pharmacology 174 (10), 1090-1103, 2017 | 30 | 2017 |
| Modulation of amyloid β-induced microglia activation and neuronal cell death by curcumin and analogues E De Lorenzi, D Franceschini, C Contardi, RMC Di Martino, F Seghetti, ... International Journal of Molecular Sciences 23 (8), 4381, 2022 | 23 | 2022 |
| Curcumin-1, 2, 3-triazole conjugation for targeting the cancer apoptosis machinery F Seghetti, RMC Di Martino, E Catanzaro, A Bisi, S Gobbi, A Rampa, ... Molecules 25 (13), 3066, 2020 | 23 | 2020 |
| Naturally inspired molecules as multifunctional agents for Alzheimer’s disease treatment A Rampa, A Tarozzi, F Mancini, L Pruccoli, RMC Di Martino, S Gobbi, ... Molecules 21 (5), 643, 2016 | 23 | 2016 |
| Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents NM de la Roche, T Mühlethaler, RMC Di Martino, JA Ortega, D Gioia, ... European Journal of Medicinal Chemistry 241, 114614, 2022 | 21 | 2022 |
| ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders S Demuro, C Sauvey, SK Tripathi, RMC Di Martino, D Shi, JA Ortega, ... European journal of medicinal chemistry 229, 114054, 2022 | 17 | 2022 |
| Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold E De Lorenzi, F Seghetti, A Tarozzi, L Pruccoli, C Contardi, M Serra, A Bisi, ... European Journal of Medicinal Chemistry 252, 115297, 2023 | 5 | 2023 |
| The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male rats V Lunerti, H Li, F Benvenuti, Q Shen, A Domi, L Soverchia, ... European Journal of Pharmacology 928, 175088, 2022 | 5 | 2022 |
