Molecular basis of triclosan activity CW Levy, A Roujeinikova, S Sedelnikova, PJ Baker, AR Stuitje, ... Nature 398 (6726), 383-384, 1999 | 694 | 1999 |
Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation KAP Payne, CP Quezada, K Fisher, MS Dunstan, FA Collins, H Sjuts, ... Nature 517 (7535), 513-516, 2015 | 315 | 2015 |
Directed evolution of an efficient and thermostable PET depolymerase EL Bell, R Smithson, S Kilbride, J Foster, FJ Hardy, S Ramachandran, ... Nature Catalysis 5 (8), 673-681, 2022 | 261 | 2022 |
The road to fully programmable protein catalysis SL Lovelock, R Crawshaw, S Basler, C Levy, D Baker, D Hilvert, ... Nature 606 (7912), 49-58, 2022 | 236 | 2022 |
Better than nature: nicotinamide biomimetics that outperform natural coenzymes T Knaus, CE Paul, CW Levy, S De Vries, FG Mutti, F Hollmann, ... Journal of the American Chemical Society 138 (3), 1033-1039, 2016 | 192 | 2016 |
Design and evolution of an enzyme with a non-canonical organocatalytic mechanism AJ Burke, SL Lovelock, A Frese, R Crawshaw, M Ortmayer, M Dunstan, ... Nature 570 (7760), 219-223, 2019 | 154 | 2019 |
The structure of Mycobacterium tuberculosis CYP125 KJ McLean, P Lafite, C Levy, MR Cheesman, N Mast, IA Pikuleva, D Leys, ... Journal of Biological Chemistry 284 (51), 35524-35533, 2009 | 151 | 2009 |
Structural basis of kynurenine 3-monooxygenase inhibition M Amaral, C Levy, DJ Heyes, P Lafite, TF Outeiro, F Giorgini, D Leys, ... Nature 496 (7445), 382-385, 2013 | 145 | 2013 |
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen MD Driscoll, KJ McLean, C Levy, N Mast, IA Pikuleva, P Lafite, SEJ Rigby, ... Journal of biological chemistry 285 (49), 38270-38282, 2010 | 138 | 2010 |
Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis S Zhang, DJ Heyes, L Feng, W Sun, LO Johannissen, H Liu, CW Levy, ... Nature 574 (7780), 722-725, 2019 | 133 | 2019 |
Crystallographic analysis of triclosan bound to enoyl reductase A Roujeinikova, CW Levy, S Rowsell, S Sedelnikova, PJ Baker, ... Journal of molecular biology 294 (2), 527-535, 1999 | 131 | 1999 |
A designed photoenzyme for enantioselective [2+ 2] cycloadditions JS Trimble, R Crawshaw, FJ Hardy, CW Levy, MJB Brown, DE Fuerst, ... Nature 611 (7937), 709-714, 2022 | 125 | 2022 |
Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes SA Shepherd, C Karthikeyan, J Latham, AW Struck, ML Thompson, ... Chemical science 6 (6), 3454-3460, 2015 | 125 | 2015 |
Synthesis and biological evaluation of coumarin-based inhibitors of NAD (P) H: quinone oxidoreductase-1 (NQO1) KA Nolan, JR Doncaster, MS Dunstan, KA Scott, AD Frenkel, D Siegel, ... Journal of medicinal chemistry 52 (22), 7142-7156, 2009 | 120 | 2009 |
Updated structure of Drosophila cryptochrome C Levy, BD Zoltowski, AR Jones, AT Vaidya, D Top, J Widom, MW Young, ... Nature 495 (7441), E3-E4, 2013 | 119 | 2013 |
Production of propane and other short-chain alkanes by structure-based engineering of ligand specificity in aldehyde-deformylating oxygenase B Khara, N Menon, C Levy, D Mansell, D Das, ENG Marsh, D Leys, ... ChemBioChem 14 (10), 1204, 2013 | 103 | 2013 |
Crystal structure of a soluble form of human CD73 with ecto‐5′‐nucleotidase activity DPHM Heuts, MJ Weissenborn, RV Olkhov, AM Shaw, J Gummadova, ... Chembiochem 13 (16), 2384-2391, 2012 | 103 | 2012 |
A structure‐guided switch in the regioselectivity of a tryptophan halogenase SA Shepherd, BRK Menon, H Fisk, AW Struck, C Levy, D Leys, ... ChemBioChem 17 (9), 821-824, 2016 | 93 | 2016 |
Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction CR Pudney, S Hay, C Levy, J Pang, MJ Sutcliffe, D Leys, NS Scrutton Journal of the American Chemical Society 131 (47), 17072-17073, 2009 | 93 | 2009 |
Catalytic determinants of alkene production by the cytochrome P450 peroxygenase OleTJE S Matthews, JD Belcher, KL Tee, HM Girvan, KJ McLean, SEJ Rigby, ... Journal of Biological Chemistry 292 (12), 5128-5143, 2017 | 91 | 2017 |