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Damien Downes
Damien Downes
Подтвержден адрес электронной почты в домене ndcls.ox.ac.uk
Название
Процитировано
Процитировано
Год
Tissue-specific CTCF–cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo
LLP Hanssen, MT Kassouf, AM Oudelaar, D Biggs, C Preece, DJ Downes, ...
Nature cell biology 19 (8), 952-961, 2017
2342017
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
DJ Ahern, Z Ai, M Ainsworth, C Allan, A Allcock, B Angus, MA Ansari, ...
Cell 185 (5), 916-938. e58, 2022
2102022
Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains
AM Oudelaar, JOJ Davies, LLP Hanssen, JM Telenius, R Schwessinger, ...
Nature genetics 50 (12), 1744-1751, 2018
1992018
DeepC: predicting 3D genome folding using megabase-scale transfer learning
R Schwessinger, M Gosden, D Downes, RC Brown, AM Oudelaar, ...
Nature methods 17 (11), 1118-1124, 2020
1892020
Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus
DJ Downes, AR Cross, P Hua, N Roberts, R Schwessinger, AJ Cutler, ...
Nature genetics 53 (11), 1606-1615, 2021
1632021
Defining genome architecture at base-pair resolution
P Hua, M Badat, LLP Hanssen, LD Hentges, N Crump, DJ Downes, ...
Nature 595 (7865), 125-129, 2021
1482021
DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation
L Godfrey, NT Crump, R Thorne, IJ Lau, E Repapi, D Dimou, AL Smith, ...
Nature communications 10 (1), 2803, 2019
1392019
Absolute quantification of transcription factors reveals principles of gene regulation in erythropoiesis
MA Gillespie, CG Palii, D Sanchez-Taltavull, P Shannon, ...
Molecular cell 78 (5), 960-974. e11, 2020
1242020
Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia
S Mettananda, CA Fisher, D Hay, M Badat, L Quek, K Clark, P Hublitz, ...
Nature communications 8 (1), 424, 2017
1132017
Hypoxia induces transcriptional and translational downregulation of the type I IFN pathway in multiple cancer cell types
A Miar, E Arnaiz, E Bridges, S Beedie, AP Cribbs, DJ Downes, ...
Cancer research 80 (23), 5245-5256, 2020
722020
Characterization of the Mutagenic Spectrum of 4-Nitroquinoline 1-Oxide (4-NQO) in Aspergillus nidulans by Whole Genome Sequencing
DJ Downes, M Chonofsky, K Tan, BT Pfannenstiel, SL Reck-Peterson, ...
G3: Genes, Genomes, Genetics 4 (12), 2483-2492, 2014
632014
Comparing the two leading erythroid lines BEL-A and HUDEP-2
DE Daniels, DJ Downes, I Ferrer-Vicens, DCJ Ferguson, BK Singleton, ...
Haematologica 105 (8), e389, 2020
472020
Enhancers predominantly regulate gene expression during differentiation via transcription initiation
MSC Larke, R Schwessinger, T Nojima, J Telenius, RA Beagrie, ...
Molecular cell 81 (5), 983-997. e7, 2021
452021
Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo
CS Simon, DJ Downes, ME Gosden, J Telenius, DR Higgs, JR Hughes, ...
Development 144 (7), 1249-1260, 2017
452017
Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture
DJ Downes, AL Smith, MA Karpinska, T Velychko, K Rue-Albrecht, D Sims, ...
Nature Protocols, 1-31, 2022
432022
Multiple nuclear localization signals mediate nuclear localization of the GATA transcription factor AreA
CC Hunter, KS Siebert, DJ Downes, KH Wong, SD Kreutzberger, ...
Eukaryotic Cell 13 (4), 527-538, 2014
412014
Impaired DNA demethylation of C/EBP sites causes premature aging
A Schäfer, B Mekker, M Mallick, V Vastolo, E Karaulanov, D Sebastian, ...
Genes & development 32 (11-12), 742-762, 2018
402018
High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale
DJ Downes, RA Beagrie, ME Gosden, J Telenius, SJ Carpenter, ...
Nature Communications 12 (1), 531, 2021
392021
LanceOtron: a deep learning peak caller for genome sequencing experiments
LD Hentges, MJ Sergeant, CB Cole, DJ Downes, JR Hughes, S Taylor
Bioinformatics 38 (18), 4255-4263, 2022
38*2022
Reactivation of a developmentally silenced embryonic globin gene
AJ King, D Songdej, DJ Downes, RA Beagrie, S Liu, M Buckley, P Hua, ...
Nature communications 12 (1), 4439, 2021
332021
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Статьи 1–20