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Anna Fryszkowska
Anna Fryszkowska
Merck & Co, Inc.
Подтвержден адрес электронной почты в домене merck.com - Главная страница
Название
Процитировано
Процитировано
Год
Design of an in vitro biocatalytic cascade for the manufacture of islatravir
MA Huffman, A Fryszkowska, O Alvizo, M Borra-Garske, KR Campos, ...
Science 366 (6470), 1255-1259, 2019
555*2019
Biocatalysis in drug discovery and development
A Fryszkowska, PN Devine
Current Opinion in Chemical Biology 55, 151-160, 2020
1602020
Biocatalysis with thermostable enzymes: structure and properties of a thermophilic ‘ene’‐reductase related to old yellow enzyme
BV Adalbjörnsson, HS Toogood, A Fryszkowska, CR Pudney, TA Jowitt, ...
ChemBioChem 11 (2), 197-207, 2010
1452010
Asymmetric reduction of activated alkenes by pentaerythritol tetranitrate reductase: specificity and control of stereochemical outcome by reaction optimisation
A Fryszkowska, H Toogood, M Sakuma, JM Gardiner, GM Stephens, ...
Advanced synthesis & catalysis 351 (17), 2976-2990, 2009
1422009
Engineered ribosyl-1-kinase enables concise synthesis of molnupiravir, an antiviral for COVID-19
JA McIntosh, T Benkovics, SM Silverman, MA Huffman, J Kong, ...
ACS Central Science 7 (12), 1980-1985, 2021
1362021
Highly Enantioselective Reduction of β,β-Disubstituted Aromatic Nitroalkenes Catalyzed by Clostridium sporogenes
A Fryszkowska, K Fisher, JM Gardiner, GM Stephens
The Journal of organic chemistry 73 (11), 4295-4298, 2008
1212008
Structure‐based insight into the asymmetric bioreduction of the C C double bond of α, β‐unsaturated nitroalkenes by pentaerythritol tetranitrate reductase
HS Toogood, A Fryszkowska, V Hare, K Fisher, A Roujeinikova, D Leys, ...
Advanced synthesis & catalysis 350 (17), 2789-2803, 2008
1082008
A site‐saturated mutagenesis study of pentaerythritol tetranitrate reductase reveals that residues 181 and 184 influence ligand binding, stereochemistry and reactivity
HS Toogood, A Fryszkowska, M Hulley, M Sakuma, D Mansell, ...
ChemBioChem 12 (5), 738-749, 2011
842011
Focused directed evolution of pentaerythritol tetranitrate reductase by using automated anaerobic kinetic screening of site‐saturated libraries
ME Hulley, HS Toogood, A Fryszkowska, D Mansell, GM Stephens, ...
ChemBioChem 11 (17), 2433-2447, 2010
712010
Canada, KA; Devine, PN; Duan, D
MA Huffman, A Fryszkowska, O Alvizo, M Borra-Garske, KR Campos
Forstater, J. H, 1255-1259, 2019
682019
Enzymatic desymmetrization of 3-arylglutaric acid anhydrides
A Fryszkowska, M Komar, D Koszelewski, R Ostaszewski
Tetrahedron: Asymmetry 16 (14), 2475-2485, 2005
472005
Asymmetric synthetic strategies of (R)-(–)-baclofen: an antispastic drug
P Ramesh, D Suman, KSN Reddy
Synthesis 50 (02), 211-226, 2018
412018
A short, chemoenzymatic route to chiral β-aryl-γ-amino acids using reductases from anaerobic bacteria
A Fryszkowska, K Fisher, JM Gardiner, GM Stephens
Organic & biomolecular chemistry 8 (3), 533-535, 2010
362010
A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins
A Fryszkowska, C An, O Alvizo, G Banerjee, KA Canada, Y Cao, ...
Science 376 (6599), 1321-1327, 2022
342022
Active site modifications in pentaerythritol tetranitrate reductase can lead to improved product enantiopurity, decreased by-product formation and altered stereochemical …
A Fryszkowska, H Toogood, M Sakuma, GM Stephens, JM Gardiner, ...
Catalysis Science & Technology 1 (6), 948-957, 2011
312011
Synthesis of Liquid Crystalline 4H-Benzo[1,2,4]thiadiazines and Generation of Persistent Radicals
J Zienkiewicz, A Fryszkowska, K Zienkiewicz, F Guo, P Kaszynski, ...
The Journal of Organic Chemistry 72 (9), 3510-3520, 2007
302007
Synthesis of islatravir enabled by a catalytic, enantioselective alkynylation of a ketone
NR Patel, CC Nawrat, M McLaughlin, Y Xu, MA Huffman, H Yang, H Li, ...
Organic Letters 22 (12), 4659-4664, 2020
292020
Electrochemical activation of galactose oxidase: Mechanistic studies and synthetic applications
S Zhang, S Ruccolo, A Fryszkowska, A Klapars, N Marshall, NA Strotman
ACS Catalysis 11 (12), 7270-7280, 2021
272021
Structural insights into the ene-reductase synthesis of profens
J Waller, HS Toogood, V Karuppiah, NJW Rattray, DJ Mansell, D Leys, ...
Organic & Biomolecular Chemistry 15 (20), 4440-4448, 2017
262017
Studies on enzymatic synthesis of chiral non-racemic 3-arylglutaric acid monoesters
A Fryszkowska, M Komar, D Koszelewski, R Ostaszewski
Tetrahedron: Asymmetry 17 (6), 961-966, 2006
262006
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