The African genome variation project shapes medical genetics in Africa D Gurdasani, T Carstensen, F Tekola-Ayele, L Pagani, I Tachmazidou, ... Nature 517 (7534), 327-332, 2015 | 679 | 2015 |
Rare variant association analysis methods for complex traits J Asimit, E Zeggini Annual review of genetics 44 (1), 293-308, 2010 | 337 | 2010 |
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes AR Majithia, J Flannick, P Shahinian, M Guo, MA Bray, P Fontanillas, ... Proceedings of the National Academy of Sciences 111 (36), 13127-13132, 2014 | 191 | 2014 |
A combined functional annotation score for non-synonymous variants MC Lopes, C Joyce, GRS Ritchie, SL John, F Cunningham, J Asimit, ... Human heredity 73 (1), 47-51, 2012 | 111 | 2012 |
Trans-ethnic study design approaches for fine-mapping JL Asimit, K Hatzikotoulas, M McCarthy, AP Morris, E Zeggini European journal of human genetics 24 (9), 1330-1336, 2016 | 99 | 2016 |
Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations Y Xue, M Mezzavilla, M Haber, S McCarthy, Y Chen, V Narasimhan, ... Nature communications 8 (1), 15927, 2017 | 84 | 2017 |
ARIEL and AMELIA: testing for an accumulation of rare variants using next-generation sequencing data JL Asimit, AG Day-Williams, AP Morris, E Zeggini Human heredity 73 (2), 84-94, 2012 | 78 | 2012 |
TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport M Schmidts, Y Hou, CR Cortés, DA Mans, C Huber, K Boldt, M Patel, ... Nature communications 6 (1), 7074, 2015 | 60 | 2015 |
Fine-mapping genetic associations A Hutchinson, J Asimit, C Wallace Human Molecular Genetics 29 (R1), R81-R88, 2020 | 50 | 2020 |
Genome‐wide association analysis of imputed rare variants: application to seven common complex diseases R Mägi, JL Asimit, AG Day‐Williams, E Zeggini, AP Morris Genetic epidemiology 36 (8), 785-796, 2012 | 40 | 2012 |
Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases JL Asimit, DB Rainbow, MD Fortune, NF Grinberg, LS Wicker, C Wallace Nature communications 10 (1), 3216, 2019 | 30 | 2019 |
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms M Horikoshi, L Pasquali, S Wiltshire, JR Huyghe, A Mahajan, JL Asimit, ... Human molecular genetics 25 (10), 2070-2081, 2016 | 26 | 2016 |
Defining the power limits of genome‐wide association scan meta‐analyses K Chapman, T Ferreira, A Morris, J Asimit, E Zeggini Genetic epidemiology 35 (8), 781-789, 2011 | 25 | 2011 |
An evaluation of different meta-analysis approaches in the presence of allelic heterogeneity J Asimit, A Day-Williams, L Zgaga, I Rudan, V Boraska, E Zeggini European Journal of Human Genetics 20 (6), 709-712, 2012 | 22 | 2012 |
Gene‐or region‐based analysis of genome‐wide association studies J Beyene, D Tritchler, JL Asimit, JS Hamid Genetic Epidemiology 33 (S1), S105-S110, 2009 | 22 | 2009 |
The flashfm approach for fine-mapping multiple quantitative traits N Hernández, J Soenksen, P Newcombe, M Sandhu, I Barroso, ... Nature communications 12 (1), 1-14, 2021 | 19 | 2021 |
Testing for rare variant associations in complex diseases J Asimit, E Zeggini Genome medicine 3, 1-3, 2011 | 19 | 2011 |
Imputation of rare variants in next-generation association studies JL Asimit, E Zeggini Human heredity 74 (3-4), 196-204, 2013 | 17 | 2013 |
Tissue-specific alteration of metabolic pathways influences glycemic regulation NHJ Ng, SM Willems, J Fernandez, RS Fine, E Wheeler, J Wessel, ... BioRxiv, 790618, 2019 | 11 | 2019 |
Region-based analysis in genome-wide association study of Framingham Heart Study blood lipid phenotypes JL Asimit, YJ Yoo, D Waggott, L Sun, SB Bull BMC proceedings 3, 1-5, 2009 | 11 | 2009 |