| Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments KM Wisdom, K Adebowale, J Chang, JY Lee, S Nam, R Desai, ... Nature communications 9 (1), 4144, 2018 | 387 | 2018 |
| Beyond proteases: Basement membrane mechanics and cancer invasion J Chang, O Chaudhuri Journal of Cell Biology 218 (8), 2456-2469, 2019 | 260 | 2019 |
| Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility RS Stowers, A Shcherbina, J Israeli, JJ Gruber, J Chang, S Nam, ... Nature biomedical engineering 3 (12), 1009-1019, 2019 | 202 | 2019 |
| YAP-independent mechanotransduction drives breast cancer progression JY Lee, JK Chang, AA Dominguez, H Lee, S Nam, J Chang, S Varma, ... Nature communications 10 (1), 1848, 2019 | 192 | 2019 |
| Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation A Sacher, P LoRusso, MR Patel, WH Miller Jr, E Garralda, MD Forster, ... New England Journal of Medicine 389 (8), 710-721, 2023 | 150 | 2023 |
| The nuclear piston activates mechanosensitive ion channels to generate cell migration paths in confining microenvironments H Lee, F Alisafaei, K Adebawale, J Chang, VB Shenoy, O Chaudhuri Science advances 7 (2), eabd4058, 2021 | 89 | 2021 |
| Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial J Desai, G Alonso, SH Kim, A Cervantes, T Karasic, L Medina, ... Nature Medicine 30 (1), 271-278, 2024 | 53 | 2024 |
| Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds AH Morris, DK Stamer, B Kunkemoeller, J Chang, H Xing, TR Kyriakides Biomaterials 169, 61-71, 2018 | 51 | 2018 |
| Osteogenic performance of donor-matched human adipose and bone marrow mesenchymal cells under dynamic culture W Wu, AV Le, JJ Mendez, J Chang, LE Niklason, DM Steinbacher Tissue Engineering Part A 21 (9-10), 1621-1632, 2015 | 51 | 2015 |
| Inadequate Processing of Decellularized Dermal Matrix Reduces Cell Viability In Vitro and Increases Apoptosis and Acute Inflammation In Vivo AH Morris, J Chang, TR Kyriakides BioResearch open access 5 (1), 177-187, 2016 | 45 | 2016 |
| Increased stiffness inhibits invadopodia formation and cell migration in 3D J Chang, EM Pang, K Adebowale, KM Wisdom, O Chaudhuri Biophysical Journal 119 (4), 726-736, 2020 | 44 | 2020 |
| Cell volume expansion and local contractility drive collective invasion of the basement membrane in breast cancer J Chang, A Saraswathibhatla, Z Song, S Varma, C Sanchez, NHK Alyafei, ... Nature materials 23 (5), 711-722, 2024 | 28 | 2024 |
| Recursive feedback between matrix dissipation and chemo-mechanical signaling drives oscillatory growth of cancer cell invadopodia Z Gong, KM Wisdom, E McEvoy, J Chang, K Adebowale, CC Price, ... Cell reports 35 (4), 2021 | 20 | 2021 |
| Abstract CT029: Phase Ib study of GDC-6036 in combination with cetuximab in patients with colorectal cancer (CRC) with KRAS G12C mutation J Desai, SW Han, JS Lee, E Shacham-Shmueli, E Massarelli, A Cervantes, ... Cancer Research 83 (8_Supplement), CT029-CT029, 2023 | 11 | 2023 |