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David Matthew Wilson
David Matthew Wilson
VP & Head, Discovery Chemistry Europe, Janssen Pharmaceuticals
Подтвержден адрес электронной почты в домене astrazeneca.com
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Процитировано
Процитировано
Год
Bedmap2: improved ice bed, surface and thickness datasets for Antarctica
P Fretwell, HD Pritchard, DG Vaughan, JL Bamber, NE Barrand, R Bell, ...
The cryosphere 7 (1), 375-393, 2013
22362013
Organic synthesis provides opportunities to transform drug discovery
DC Blakemore, L Castro, I Churcher, DC Rees, AW Thomas, DM Wilson, ...
Nature chemistry 10 (4), 383-394, 2018
12972018
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
L Kruidenier, C Chung, Z Cheng, J Liddle, KH Che, G Joberty, ...
Nature 488 (7411), 404-408, 2012
9942012
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation
HD Lewis, J Liddle, JE Coote, SJ Atkinson, MD Barker, BD Bax, KL Bicker, ...
Nature chemical biology 11 (3), 189-191, 2015
7242015
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia
AE Tron, MA Belmonte, A Adam, BM Aquila, LH Boise, E Chiarparin, ...
Nature communications 9 (1), 5341, 2018
5032018
GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models
AD Medhurst, AR Atkins, IJ Beresford, K Brackenborough, MA Briggs, ...
Journal of Pharmacology and Experimental Therapeutics 321 (3), 1032-1045, 2007
3562007
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885
AJ King, DR Patrick, RS Batorsky, ML Ho, HT Do, SY Zhang, R Kumar, ...
Cancer research 66 (23), 11100-11105, 2006
3092006
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase
AK Takle, MJB Brown, S Davies, DK Dean, G Francis, A Gaiba, AW Hird, ...
Bioorganic & medicinal chemistry letters 16 (2), 378-381, 2006
2622006
Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A)
J Seal, Y Lamotte, F Donche, A Bouillot, O Mirguet, F Gellibert, ...
Bioorganic & medicinal chemistry letters 22 (8), 2968-2972, 2012
2562012
DNA damage and associated DNA repair defects in disease and premature aging
V Tiwari, DM Wilson
The American Journal of Human Genetics 105 (2), 237-257, 2019
2472019
iPTF16geu: A multiply imaged, gravitationally lensed type Ia supernova
A Goobar, R Amanullah, SR Kulkarni, PE Nugent, J Johansson, C Steidel, ...
Science 356 (6335), 291-295, 2017
2412017
Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides
P Bamborough, H Diallo, JD Goodacre, L Gordon, A Lewis, JT Seal, ...
Journal of medicinal chemistry 55 (2), 587-596, 2012
2152012
EED-targeted PROTACs degrade EED, EZH2, and SUZ12 in the PRC2 complex
JHR Hsu, T Rasmusson, J Robinson, F Pachl, J Read, S Kawatkar, ...
Cell chemical biology 27 (1), 41-46. e17, 2020
1912020
Palladium catalysed tandem cyclisation-anion capture processes. Part 3. Organoboron anion transfer agents
R Grigg, JM Sansano, V Santhakumar, V Sridharan, R Thangavelanthum, ...
Tetrahedron 53 (34), 11803-11826, 1997
1761997
Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions
RW Maul, H Saribasak, SA Martomo, RL McClure, W Yang, A Vaisman, ...
Nature immunology 12 (1), 70-76, 2011
1582011
Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders
J Spaas, L Van Veggel, M Schepers, A Tiane, J Van Horssen, ...
Cellular and Molecular Life Sciences 78 (10), 4615-4637, 2021
1502021
Potent and selective bivalent inhibitors of BET bromodomains
MJ Waring, H Chen, AA Rabow, G Walker, R Bobby, S Boiko, ...
Nature chemical biology 12 (12), 1097-1104, 2016
1452016
Development of a novel B-cell lymphoma 6 (BCL6) PROTAC to provide insight into small molecule targeting of BCL6
W McCoull, T Cheung, E Anderson, P Barton, J Burgess, K Byth, Q Cao, ...
ACS Chemical Biology 13 (11), 3131-3141, 2018
1412018
Somatostatin receptor-binding peptides labeled with technetium-99m: chemistry and initial biological studies
DA Pearson, J Lister-James, WJ McBride, DM Wilson, LJ Martel, ...
Journal of medicinal chemistry 39 (7), 1361-1371, 1996
1301996
Palladium Catalysed Tandem Cyclisation–Anion Capture Processes. Part 4: Organotin (IV) Transfer Agents
P Fretwell, R Grigg, JM Sansano, V Sridharan, S Sukirthalingam, ...
Tetrahedron 56 (38), 7525-7539, 2000
1042000
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