Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides L Cascales, ST Henriques, MC Kerr, YH Huang, MJ Sweet, NL Daly, ... Journal of Biological Chemistry 286 (42), 36932-36943, 2011 | 221 | 2011 |
Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities ST Henriques, YH Huang, KJ Rosengren, HG Franquelim, FA Carvalho, ... Journal of Biological Chemistry 286 (27), 24231-24241, 2011 | 202 | 2011 |
Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep ML Colgrave, AC Kotze, YH Huang, J O’Grady, SM Simonsen, DJ Craik Biochemistry 47 (20), 5581-5589, 2008 | 197 | 2008 |
Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria IM Torcato, YH Huang, HG Franquelim, D Gaspar, DJ Craik, ... Biochimica et Biophysica Acta (BBA)-Biomembranes 1828 (3), 944-955, 2013 | 192 | 2013 |
The biological activity of the prototypic cyclotide kalata b1 is modulated by the formation of multimeric pores YH Huang, ML Colgrave, NL Daly, A Keleshian, B Martinac, DJ Craik Journal of Biological Chemistry 284 (31), 20699-20707, 2009 | 182 | 2009 |
High-affinity cyclic peptide matriptase inhibitors P Quimbar, U Malik, CP Sommerhoff, Q Kaas, LY Chan, YH Huang, ... Journal of Biological Chemistry 288 (19), 13885-13896, 2013 | 159 | 2013 |
Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions ST Henriques, YH Huang, MARB Castanho, LA Bagatolli, S Sonza, ... Journal of Biological Chemistry 287 (40), 33629-33643, 2012 | 144 | 2012 |
Fmoc-based synthesis of disulfide-rich cyclic peptides O Cheneval, CI Schroeder, T Durek, P Walsh, YH Huang, S Liras, ... The Journal of organic chemistry 79 (12), 5538-5544, 2014 | 138 | 2014 |
Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity YH Huang, ML Colgrave, RJ Clark, AC Kotze, DJ Craik Journal of Biological Chemistry 285 (14), 10797-10805, 2010 | 129 | 2010 |
Accurate de novo design of membrane-traversing macrocycles G Bhardwaj, J O’Connor, S Rettie, YH Huang, TA Ramelot, VK Mulligan, ... Cell 185 (19), 3520-3532. e26, 2022 | 107 | 2022 |
Semienzymatic cyclization of disulfide-rich peptides using Sortase A X Jia, S Kwon, CIA Wang, YH Huang, LY Chan, CC Tan, KJ Rosengren, ... Journal of biological chemistry 289 (10), 6627-6638, 2014 | 106 | 2014 |
The prototypic cyclotide kalata B1 has a unique mechanism of entering cells ST Henriques, YH Huang, S Chaousis, MA Sani, AG Poth, F Separovic, ... Chemistry & biology 22 (8), 1087-1097, 2015 | 99 | 2015 |
Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity LY Chan, VM Zhang, Y Huang, NC Waters, PS Bansal, DJ Craik, NL Daly ChemBioChem 14 (5), 617-624, 2013 | 96 | 2013 |
Cyclotides suppress human T-lymphocyte proliferation by an interleukin 2-dependent mechanism C Gründemann, K Thell, K Lengen, M Garcia-Käufer, YH Huang, R Huber, ... PLoS One 8 (6), e68016, 2013 | 93 | 2013 |
Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting S Troeira Henriques, YH Huang, S Chaousis, CK Wang, DJ Craik ChemBioChem 15 (13), 1956-1965, 2014 | 83 | 2014 |
Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold YH Huang, ST Henriques, CK Wang, L Thorstholm, NL Daly, Q Kaas, ... Scientific reports 5 (1), 12974, 2015 | 74 | 2015 |
Characterization of tachyplesin peptides and their cyclized analogues to improve antimicrobial and anticancer properties F Vernen, PJ Harvey, SA Dias, AS Veiga, YH Huang, DJ Craik, ... International Journal of Molecular Sciences 20 (17), 4184, 2019 | 69 | 2019 |
The antimicrobial activity of Sub3 is dependent on membrane binding and cell‐penetrating ability IM Torcato, YH Huang, HG Franquelim, DD Gaspar, DJ Craik, ... Chembiochem 14 (15), 2013-2022, 2013 | 68 | 2013 |
Redesigned spider peptide with improved antimicrobial and anticancer properties S Troeira Henriques, N Lawrence, S Chaousis, AS Ravipati, O Cheneval, ... ACS Chemical Biology 12 (9), 2324-2334, 2017 | 64 | 2017 |
Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold CK Wang, SE Northfield, YH Huang, MC Ramos, DJ Craik European journal of medicinal chemistry 109, 342-349, 2016 | 58 | 2016 |