| Ultra-large library docking for discovering new chemotypes J Lyu, S Wang, TE Balius, I Singh, A Levit, YS Moroz, MJ O’Meara, T Che, ... Nature 566 (7743), 224-229, 2019 | 866 | 2019 |
| Crystal structure of an LSD-bound human serotonin receptor D Wacker, S Wang, JD McCorvy, RM Betz, AJ Venkatakrishnan, A Levit, ... Cell 168 (3), 377-389. e12, 2017 | 501 | 2017 |
| Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone S Wang, T Che, A Levit, BK Shoichet, D Wacker, BL Roth Nature 555 (7695), 269-273, 2018 | 477 | 2018 |
| TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome RHJ Olsen, JF DiBerto, JG English, AM Glaudin, BE Krumm, ST Slocum, ... Nature chemical biology 16 (8), 841-849, 2020 | 430 | 2020 |
| Structure of a hallucinogen-activated Gq-coupled 5-HT2A serotonin receptor K Kim, T Che, O Panova, JF DiBerto, J Lyu, BE Krumm, D Wacker, ... Cell 182 (6), 1574-1588. e19, 2020 | 408 | 2020 |
| Structure of the nanobody-stabilized active state of the kappa opioid receptor T Che, S Majumdar, SA Zaidi, P Ondachi, JD McCorvy, S Wang, ... Cell 172 (1), 55-67. e15, 2018 | 388 | 2018 |
| Virtual discovery of melatonin receptor ligands to modulate circadian rhythms RM Stein, HJ Kang, JD McCorvy, GC Glatfelter, AJ Jones, T Che, ... Nature 579 (7800), 609-614, 2020 | 278 | 2020 |
| In silico design of novel probes for the atypical opioid receptor MRGPRX2 K Lansu, J Karpiak, J Liu, XP Huang, JD McCorvy, WK Kroeze, T Che, ... Nature chemical biology 13 (5), 529-536, 2017 | 272 | 2017 |
| 5-HT2C receptor structures reveal the structural basis of GPCR polypharmacology Y Peng, JD McCorvy, K Harpsøe, K Lansu, S Yuan, P Popov, L Qu, M Pu, ... Cell 172 (4), 719-730. e14, 2018 | 249 | 2018 |
| D4 dopamine receptor high-resolution structures enable the discovery of selective agonists S Wang, D Wacker, A Levit, T Che, RM Betz, JD McCorvy, ... Science 358 (6361), 381-386, 2017 | 245 | 2017 |
| Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity AL Kaplan, DN Confair, K Kim, X Barros-Álvarez, RM Rodriguiz, Y Yang, ... Nature 610 (7932), 582-591, 2022 | 180 | 2022 |
| Structural determinants of 5-HT2B receptor activation and biased agonism JD McCorvy, D Wacker, S Wang, B Agegnehu, J Liu, K Lansu, AR Tribo, ... Nature structural & molecular biology 25 (9), 787-796, 2018 | 156 | 2018 |
| Nanobody-enabled monitoring of kappa opioid receptor states T Che, J English, BE Krumm, K Kim, E Pardon, RHJ Olsen, S Wang, ... Nature communications 11 (1), 1145, 2020 | 123 | 2020 |
| Biased ligands at opioid receptors: Current status and future directions T Che, H Dwivedi-Agnihotri, AK Shukla, BL Roth Science signaling 14 (677), eaav0320, 2021 | 97 | 2021 |
| Structure determination of inactive-state GPCRs with a universal nanobody MJ Robertson, MM Papasergi-Scott, F He, AB Seven, JG Meyerowitz, ... Nature Structural & Molecular Biology 29 (12), 1188-1195, 2022 | 89 | 2022 |
| Insights into distinct signaling profiles of the µOR activated by diverse agonists Q Qu, W Huang, D Aydin, JM Paggi, AB Seven, H Wang, S Chakraborty, ... Nature chemical biology 19 (4), 423-430, 2023 | 81 | 2023 |
| Structure-based design of bitopic ligands for the µ-opioid receptor A Faouzi, H Wang, SA Zaidi, JF DiBerto, T Che, Q Qu, MJ Robertson, ... Nature 613 (7945), 767-774, 2023 | 78 | 2023 |
| Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site R Uprety, T Che, SA Zaidi, SG Grinnell, BR Varga, A Faouzi, ST Slocum, ... Elife 10, e56519, 2021 | 61 | 2021 |
| Molecular mechanism of biased signaling at the kappa opioid receptor A El Daibani, JM Paggi, K Kim, YD Laloudakis, P Popov, SM Bernhard, ... Nature communications 14 (1), 1338, 2023 | 56 | 2023 |
| A novel mitragynine analog with low-efficacy mu opioid receptor agonism displays antinociception with attenuated adverse effects S Chakraborty, JF DiBerto, A Faouzi, SM Bernhard, AM Gutridge, ... Journal of medicinal chemistry 64 (18), 13873-13892, 2021 | 51 | 2021 |
BL RothDepartment of Pharmacology, University of North Carolina Medical SchoolПодтвержден адрес электронной почты в домене med.unc.edu