Scalable mRNA and siRNA lipid nanoparticle production using a parallelized microfluidic device SJ Shepherd, CC Warzecha, S Yadavali, R El-Mayta, MG Alameh, ... Nano Letters 21 (13), 5671-5680, 2021 | 198 | 2021 |
Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver R Zhang, R El-Mayta, TJ Murdoch, CC Warzecha, MM Billingsley, ... Biomaterials Science 9 (4), 1449-1463, 2021 | 171 | 2021 |
Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening PPG Guimaraes, R Zhang, R Spektor, M Tan, A Chung, MM Billingsley, ... Journal of Controlled Release 316, 404-417, 2019 | 166 | 2019 |
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis X Han, N Gong, L Xue, MM Billingsley, R El-Mayta, SJ Shepherd, ... Nature Communications 14 (1), 75, 2023 | 87 | 2023 |
In vivo mRNA CAR T cell engineering via targeted ionizable lipid nanoparticles with extrahepatic tropism MM Billingsley, N Gong, AJ Mukalel, AS Thatte, R El‐Mayta, SK Patel, ... Small 20 (11), 2304378, 2024 | 51 | 2024 |
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines SJ Shepherd, X Han, AJ Mukalel, R El-Mayta, AS Thatte, J Wu, MS Padilla, ... Proceedings of the National Academy of Sciences 120 (33), e2303567120, 2023 | 45 | 2023 |
Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy K Butowska, X Han, N Gong, R El-Mayta, RM Haley, L Xue, W Zhong, ... Acta Pharmaceutica Sinica B 13 (4), 1429-1437, 2023 | 41 | 2023 |
Delivery technologies to engineer natural killer cells for cancer immunotherapy R El-Mayta, Z Zhang, AG Hamilton, MJ Mitchell Cancer Gene Therapy 28 (9), 947-959, 2021 | 37 | 2021 |
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models L Xue, AG Hamilton, G Zhao, Z Xiao, R El-Mayta, X Han, N Gong, X Xiong, ... Nature Communications 15 (1), 1884, 2024 | 36 | 2024 |
In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity N Gong, X Han, L Xue, R El-Mayta, AE Metzloff, MM Billingsley, ... Nature Materials 22 (12), 1571-1580, 2023 | 32 | 2023 |
A Nanoparticle Platform for Accelerated In Vivo Oral Delivery Screening of Nucleic Acids R El‐Mayta, R Zhang, SJ Shepherd, F Wang, MM Billingsley, V Dudkin, ... Advanced Therapeutics 4 (1), 2000111, 2021 | 31 | 2021 |
In vivo bone marrow microenvironment siRNA delivery using lipid–polymer nanoparticles for multiple myeloma therapy PPG Guimarães, CG Figueroa-Espada, RS Riley, N Gong, L Xue, ... Proceedings of the National Academy of Sciences 120 (25), e2215711120, 2023 | 30 | 2023 |
Enhancing in situ cancer vaccines using delivery technologies N Gong, MG Alameh, R El-Mayta, L Xue, D Weissman, MJ Mitchell Nature Reviews Drug Discovery 23 (8), 607-625, 2024 | 20 | 2024 |
Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery SK Patel, MM Billingsley, AJ Mukalel, AS Thatte, AG Hamilton, N Gong, ... Theranostics 14 (1), 1, 2024 | 20 | 2024 |
In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors X Han, J Xu, Y Xu, MG Alameh, L Xue, N Gong, R El-Mayta, R Palanki, ... Nature Communications 15 (1), 1762, 2024 | 16 | 2024 |
Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction M Huang, F Yang, D Zhang, M Lin, H Duan, R El-Mayta, L Zhang, L Qin, ... Nature Cardiovascular Research 1 (4), 372-388, 2022 | 14 | 2022 |
Testing the in vitro and in vivo efficiency of mRNA-lipid nanoparticles formulated by microfluidic mixing R El-Mayta, MS Padilla, MM Billingsley, X Han, MJ Mitchell Journal of Visualized Experiments, 2023 | 12 | 2023 |
Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo X Han, MG Alameh, N Gong, L Xue, M Ghattas, G Bojja, J Xu, G Zhao, ... Nature chemistry 16 (10), 1687-1697, 2024 | 10 | 2024 |
An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma F Yang, MN Akhtar, D Zhang, R El-Mayta, J Shin, JF Dorsey, L Zhang, ... Science Advances 10 (9), eadj4678, 2024 | 9 | 2024 |
High-Throughput In Vivo Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route AG Hamilton, KL Swingle, AS Thatte, AJ Mukalel, HC Safford, ... ACS Nano, 2024 | 7 | 2024 |