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Shane W. Krska
Shane W. Krska
Distinguished Scientist, Merck Research Laboratories
Подтвержден адрес электронной почты в домене merck.com
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Процитировано
Процитировано
Год
The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
T Cernak, KD Dykstra, S Tyagarajan, P Vachal, SW Krska
Chemical Society Reviews 45 (3), 546-576, 2016
15792016
Late‐stage functionalization of biologically active heterocycles through photoredox catalysis
DA DiRocco, K Dykstra, S Krska, P Vachal, DV Conway, M Tudge
Angewandte Chemie International Edition 53 (19), 4802-4806, 2014
4942014
Cobalt precursors for high-throughput discovery of base metal asymmetric alkene hydrogenation catalysts
MR Friedfeld, M Shevlin, JM Hoyt, SW Krska, MT Tudge, PJ Chirik
Science 342 (6162), 1076-1080, 2013
3792013
Highly efficient asymmetric synthesis of sitagliptin
KB Hansen, Y Hsiao, F Xu, N Rivera, A Clausen, M Kubryk, S Krska, ...
Journal of the American Chemical Society 131 (25), 8798-8804, 2009
3562009
The evolution of chemical high-throughput experimentation to address challenging problems in pharmaceutical synthesis
SW Krska, DA DiRocco, SD Dreher, M Shevlin
Accounts of chemical research 50 (12), 2976-2985, 2017
3132017
Highly efficient synthesis of β-amino acid derivatives via asymmetric hydrogenation of unprotected enamines
Y Hsiao, NR Rivera, T Rosner, SW Krska, E Njolito, F Wang, Y Sun, ...
Journal of the American Chemical Society 126 (32), 9918-9919, 2004
3112004
High-throughput optimization of Ir-catalyzed C–H borylation: a tutorial for practical applications
SM Preshlock, B Ghaffari, PE Maligres, SW Krska, RE Maleczka Jr, ...
Journal of the American Chemical Society 135 (20), 7572-7582, 2013
2452013
A traceless directing group for C–H borylation
SM Preshlock, DL Plattner, PE Maligres, SW Krska, RE Maleczka Jr, ...
Angewandte Chemie (International ed. in English) 52 (49), 12915, 2013
2182013
Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods
PS Kutchukian, JF Dropinski, KD Dykstra, B Li, DA DiRocco, ...
Chemical science 7 (4), 2604-2613, 2016
2112016
Unlocking the potential of asymmetric hydrogenation at Merck
CS Shultz, SW Krska
Accounts of chemical research 40 (12), 1320-1326, 2007
2102007
Silyl phosphorus and nitrogen donor chelates for homogeneous ortho borylation catalysis
B Ghaffari, SM Preshlock, DL Plattner, RJ Staples, PE Maligres, SW Krska, ...
Journal of the American Chemical Society 136 (41), 14345-14348, 2014
1682014
C (sp3)–H methylation enabled by peroxide photosensitization and Ni-mediated radical coupling
A Vasilopoulos, SW Krska, SS Stahl
Science 372 (6540), 398-403, 2021
1582021
Zirconium-mediated metathesis of imines: A study of the scope, longevity, and mechanism of a complicated catalytic system
RL Zuckerman, SW Krska, RG Bergman
Journal of the American Chemical Society 122 (5), 751-761, 2000
1542000
Pharmaceutical diversification via palladium oxidative addition complexes
MR Uehling, RP King, SW Krska, T Cernak, SL Buchwald
Science 363 (6425), 405-408, 2019
1532019
Copper-catalysed benzylic C–H coupling with alcohols via radical relay enabled by redox buffering
H Hu, SJ Chen, M Mandal, SM Pratik, JA Buss, SW Krska, CJ Cramer, ...
Nature catalysis 3 (4), 358-367, 2020
1502020
Photoredox-catalyzed hydroxymethylation of heteroaromatic bases
CA Huff, RD Cohen, KD Dykstra, E Streckfuss, DA DiRocco, SW Krska
The Journal of Organic Chemistry 81 (16), 6980-6987, 2016
1372016
Synthesis of water-soluble carbosilane dendrimers
SW Krska, D Seyferth
Journal of the American Chemical Society 120 (15), 3604-3612, 1998
1271998
Reaction development and mechanistic study of a ruthenium catalyzed intramolecular asymmetric reductive amination en route to the dual orexin inhibitor suvorexant (MK-4305)
NA Strotman, CA Baxter, KMJ Brands, E Cleator, SW Krska, RA Reamer, ...
Journal of the American Chemical Society 133 (21), 8362-8371, 2011
1262011
Designed Ligands as Probes for the Catalytic Binding Mode in Mo-Catalyzed Asymmetric Allylic Alkylation We thank the National Science Foundation and the National Institutes of …
BM Trost, K Dogra, I Hachiya, T Emura, DL Hughes, S Krska, RA Reamer, ...
Angewandte Chemie 114 (11), 2009, 2002
1242002
Protecting group free radical C–H trifluoromethylation of peptides
N Ichiishi, JP Caldwell, M Lin, W Zhong, X Zhu, E Streckfuss, HY Kim, ...
Chemical science 9 (17), 4168-4175, 2018
1192018
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