| Computational tools help improve protein stability but with a solubility tradeoff A Broom, Z Jacobi, K Trainor, EM Meiering Journal of Biological Chemistry 292 (35), 14349-14361, 2017 | 119 | 2017 |
| Modular evolution and the origins of symmetry: reconstruction of a three-fold symmetric globular protein A Broom, AC Doxey, YD Lobsanov, LG Berthin, DR Rose, PL Howell, ... Structure 20 (1), 161-171, 2012 | 108 | 2012 |
| Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico A Broom, RV Rakotoharisoa, MC Thompson, N Zarifi, E Nguyen, ... Nature communications 11 (1), 4808, 2020 | 98 | 2020 |
| Exploring the relationships between protein sequence, structure and solubility K Trainor, A Broom, EM Meiering Current opinion in structural biology 42, 136-146, 2017 | 80 | 2017 |
| Energetics of oligomeric protein folding and association CM Doyle, JA Rumfeldt, HR Broom, A Broom, PB Stathopulos, KA Vassall, ... Archives of biochemistry and biophysics 531 (1-2), 44-64, 2013 | 63 | 2013 |
| Computational modeling of protein stability: quantitative analysis reveals solutions to pervasive problems A Broom, K Trainor, Z Jacobi, EM Meiering Structure 28 (6), 717-726. e3, 2020 | 43 | 2020 |
| Designed protein reveals structural determinants of extreme kinetic stability A Broom, SM Ma, K Xia, H Rafalia, K Trainor, W Colón, S Gosavi, ... Proceedings of the National Academy of Sciences 112 (47), 14605-14610, 2015 | 39 | 2015 |
| Protein unfolding rates correlate as strongly as folding rates with native structure A Broom, S Gosavi, EM Meiering Protein Science 24 (4), 580-587, 2015 | 33 | 2015 |
| Nonnative interactions regulate folding and switching of myristoylated protein D Shental-Bechor, MTJ Smith, D MacKenzie, A Broom, A Marcovitz, ... Proceedings of the National Academy of Sciences 109 (44), 17839-17844, 2012 | 32 | 2012 |
| Kinetic stability of the streptavidin–biotin interaction enhanced in the gas phase L Deng, A Broom, EN Kitova, MR Richards, RB Zheng, GK Shoemaker, ... Journal of the American Chemical Society 134 (40), 16586-16596, 2012 | 30 | 2012 |
| Origin of conformational dynamics in a globular protein AM Damry, MM Mayer, A Broom, NK Goto, RA Chica Communications Biology 2 (1), 433, 2019 | 14 | 2019 |
| Folding and association of thermophilic dimeric and trimeric DsrEFH proteins: Tm0979 and Mth1491 C Galvagnion, MTJ Smith, A Broom, KA Vassall, G Meglei, JA Gaspar, ... Biochemistry 48 (13), 2891-2906, 2009 | 14 | 2009 |
| Asymmetric anchoring is required for efficient Ω-loop opening and closing in cytosolic phosphoenolpyruvate carboxykinase DS Cui, A Broom, MJ Mcleod, EM Meiering, T Holyoak Biochemistry 56 (15), 2106-2115, 2017 | 13 | 2017 |
| Evolution of an enzyme conformational ensemble guides design of an efficient biocatalyst A Broom, RV Rakotoharisoa, MC Thompson, N Zarifi, E Nguyen, ... bioRxiv, 2020.03. 19.999235, 2020 | 12 | 2020 |
| Using natural sequences and modularity to design common and novel protein topologies A Broom, K Trainor, DWS MacKenzie, EM Meiering Current Opinion in Structural Biology 38, 26-36, 2016 | 12 | 2016 |
| A fine balance of hydrophobic-electrostatic communication pathways in a pH-switching protein DWS MacKenzie, A Schaefer, J Steckner, CA Leo, D Naser, E Artikis, ... Proceedings of the National Academy of Sciences 119 (26), e2119686119, 2022 | 7 | 2022 |
| Personalized oncology and BRAFK601N melanoma: model development, drug discovery, and clinical correlation BA Keller, BJ Laight, O Varette, A Broom, MÈ Wedge, B McSweeney, ... Journal of Cancer Research and Clinical Oncology 147, 1365-1378, 2021 | 5 | 2021 |
| On the analytical representation of free energy profiles with a Morse/long-range model: Application to the water dimer Y Tritzant-Martinez, T Zeng, A Broom, E Meiering, RJ Le Roy, PN Roy The Journal of Chemical Physics 138 (23), 2013 | 5 | 2013 |
| Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico RV Rakotoharisoa, A Broom, MC Thompson, N Zarifi, E Nguyen, ... PROTEIN SCIENCE 30, 93-93, 2021 | | 2021 |
