PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect S Tunaru, J Kero, A Schaub, C Wufka, A Blaukat, K Pfeffer, S Offermanns Nature medicine 9 (3), 352-355, 2003 | 927 | 2003 |
An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81 K Ahmed, S Tunaru, C Tang, M Müller, A Gille, A Sassmann, J Hanson, ... Cell metabolism 11 (4), 311-319, 2010 | 459 | 2010 |
Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes C Tang, K Ahmed, A Gille, S Lu, HJ Gröne, S Tunaru, S Offermanns Nature medicine 21 (2), 173-177, 2015 | 375 | 2015 |
Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors S Tunaru, TF Althoff, RM Nüsing, M Diener, S Offermanns Proceedings of the National Academy of Sciences 109 (23), 9179-9184, 2012 | 296 | 2012 |
GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors K Ahmed, S Tunaru, S Offermanns Trends in pharmacological sciences 30 (11), 557-562, 2009 | 287 | 2009 |
Nicotinic acid–and monomethyl fumarate–induced flushing involves GPR109A expressed by keratinocytes and COX-2–dependent prostanoid formation in mice J Hanson, A Gille, S Zwykiel, M Lukasova, BE Clausen, K Ahmed, ... The Journal of clinical investigation 120 (8), 2910-2919, 2010 | 222 | 2010 |
Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development J Kero, K Ahmed, N Wettschureck, S Tunaru, T Wintermantel, E Greiner, ... The Journal of clinical investigation 117 (9), 2399-2407, 2007 | 157 | 2007 |
Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G) S Tunaru, J Lättig, J Kero, G Krause, S Offermanns Molecular pharmacology 68 (5), 1271-1280, 2005 | 148 | 2005 |
Conserved MIP receptor–ligand pair regulates Platynereis larval settlement M Conzelmann, EA Williams, S Tunaru, N Randel, R Shahidi, A Asadulina, ... Proceedings of the National Academy of Sciences 110 (20), 8224-8229, 2013 | 128 | 2013 |
Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials M Lukasova, J Hanson, S Tunaru, S Offermanns Trends in pharmacological sciences 32 (12), 700-707, 2011 | 118 | 2011 |
Deorphanization of GPR109B as a receptor for the β-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis K Ahmed, S Tunaru, CD Langhans, J Hanson, CW Michalski, S Kölker, ... Journal of Biological Chemistry 284 (33), 21928-21933, 2009 | 100 | 2009 |
20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1 S Tunaru, R Bonnavion, I Brandenburger, J Preussner, D Thomas, ... Nature communications 9 (1), 177, 2018 | 95 | 2018 |
Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63 A Niedernberg, S Tunaru, A Blaukat, A Ardati, E Kostenis Cellular signalling 15 (4), 435-446, 2003 | 77 | 2003 |
Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis K Schmitz, R Brunkhorst, N De Bruin, CA Mayer, A Häussler, N Ferreiros, ... Acta neuropathologica communications 5, 1-18, 2017 | 59 | 2017 |
The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity SW Hohmann, C Angioni, S Tunaru, S Lee, CJ Woolf, S Offermanns, ... Scientific Reports 7 (1), 446, 2017 | 54 | 2017 |
A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development CSM Helker, ST Mullapudi, LM Mueller, J Preussner, S Tunaru, O Skog, ... Development 146 (14), dev172569, 2019 | 39 | 2019 |
Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors A Niedernberg, S Tunaru, A Blaukat, B Harris, E Kostenis Journal of biomolecular screening 8 (5), 500-510, 2003 | 38 | 2003 |
Arachidonic acid metabolite 19 (S)-HETE induces vasorelaxation and platelet inhibition by activating prostacyclin (IP) receptor S Tunaru, R Chennupati, RM Nüsing, S Offermanns PloS one 11 (9), e0163633, 2016 | 36 | 2016 |
The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons S Zinn, M Sisignano, K Kern, S Pierre, S Tunaru, H Jordan, J Suo, ... Journal of Biological Chemistry 292 (15), 6123-6134, 2017 | 31 | 2017 |
A novel luminescence-based method for the detection of functionally active antibodies to muscarinic acetylcholine receptors of the M3 type (mAchR3) in patients' sera B Preuss, S Tunaru, J Henes, S Offermanns, R Klein Clinical & Experimental Immunology 177 (1), 179-189, 2014 | 27 | 2014 |