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Deeptak Verma
Deeptak Verma
Merck
Подтвержден адрес электронной почты в домене merck.com - Главная страница
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Процитировано
Год
Design of an in vitro biocatalytic cascade for the manufacture of islatravir
MA Huffman, A Fryszkowska, O Alvizo, M Borra-Garske, KR Campos, ...
Science 366 (6470), 1255-1259, 2019
5162019
Deep dive into machine learning models for protein engineering
Y Xu, D Verma, RP Sheridan, A Liaw, J Ma, NM Marshall, J McIntosh, ...
Journal of chemical information and modeling 60 (6), 2773-2790, 2020
2162020
Engineered ribosyl-1-kinase enables concise synthesis of molnupiravir, an antiviral for COVID-19
JA McIntosh, T Benkovics, SM Silverman, MA Huffman, J Kong, ...
ACS Central Science 7 (12), 1980-1985, 2021
1362021
A kinase-cGAS cascade to synthesize a therapeutic STING activator
JA McIntosh, Z Liu, BM Andresen, NS Marzijarani, JC Moore, NM Marshall, ...
Nature 603 (7901), 439-444, 2022
882022
Using enzymes to tame nitrogen-centred radicals for enantioselective hydroamination
Y Ye, J Cao, DG Oblinsky, D Verma, CK Prier, GD Scholes, TK Hyster
Nature chemistry 15 (2), 206-212, 2023
752023
Depletion of T cell epitopes in lysostaphin mitigates anti-drug antibody response and enhances antibacterial efficacy in vivo
H Zhao, D Verma, W Li, Y Choi, C Ndong, SN Fiering, C Bailey-Kellogg, ...
Chemistry & biology 22 (5), 629-639, 2015
602015
Changes in lysozyme flexibility upon mutation are frequent, large and long-ranged
D Verma, DJ Jacobs, DR Livesay
PLoS computational biology 8 (3), e1002409, 2012
562012
Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity
RS Salvat, D Verma, AS Parker, JR Kirsch, SA Brooks, C Bailey-Kellogg, ...
Proceedings of the National Academy of Sciences 114 (26), E5085-E5093, 2017
432017
Docking mode of delvardine and its analogues into the p66 domain of HIV-1 reverse transcriptase: screening using molecular mechanics-generalized born/surface area and …
D Sengupta, D Verma, PK Naik
Journal of biosciences 32, 1307-1316, 2007
422007
Diverse catalytic reactions for the stereoselective synthesis of cyclic dinucleotide MK-1454
T Benkovics, F Peng, EM Phillips, C An, RS Bade, CK Chung, ZEX Dance, ...
Journal of the American Chemical Society 144 (13), 5855-5863, 2022
362022
EpiSweep: Computationally driven reengineering of therapeutic proteins to reduce immunogenicity while maintaining function
Y Choi, D Verma, KE Griswold, C Bailey-Kellogg
Computational protein design, 375-398, 2017
352017
Globally deimmunized lysostaphin evades human immune surveillance and enables highly efficacious repeat dosing
H Zhao, SA Brooks, S Eszterhas, S Heim, L Li, YQ Xiong, Y Fang, ...
Science advances 6 (36), eabb9011, 2020
332020
Variations within class-A β-lactamase physiochemical properties reflect evolutionary and environmental patterns, but not antibiotic specificity
D Verma, DJ Jacobs, DR Livesay
PLoS computational biology 9 (7), e1003155, 2013
322013
Characterization of potent RSV neutralizing antibodies isolated from human memory B cells and identification of diverse RSV/hMPV cross-neutralizing epitopes
X Xiao, A Tang, KS Cox, Z Wen, C Callahan, NL Sullivan, DD Nahas, ...
MAbs 11 (8), 1415-1427, 2019
282019
Evolving to an ideal synthesis of molnupiravir, an investigational treatment for COVID-19
T Benkovics, J McIntosh, S Silverman, J Kong, P Maligres, T Itoh, H Yang, ...
222020
Thermodynamic stability and flexibility characteristics of antibody fragment complexes
T Li, D Verma, M B Tracka, J Casas-Finet, D R Livesay, D J Jacobs
Protein and peptide letters 21 (8), 752-765, 2014
202014
Ensemble properties of network rigidity reveal allosteric mechanisms
DJ Jacobs, DR Livesay, JM Mottonen, OK Vorov, AY Istomin, D Verma
Allostery: Methods and Protocols, 279-304, 2012
202012
Similarity based enzymatic retrosynthesis
K Sankaranarayanan, E Heid, CW Coley, D Verma, WH Green, ...
Chemical Science 13 (20), 6039-6053, 2022
192022
Building blocks and blueprints for bacterial autolysins
SJ Mitchell, D Verma, KE Griswold, C Bailey-Kellogg
PLoS Computational Biology 17 (4), e1008889, 2021
192021
Enantioselective enzymatic reduction of acrylic acids
C An, MH Shaw, A Tharp, D Verma, H Li, H Wang, X Wang
Organic Letters 22 (21), 8320-8325, 2020
182020
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