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Aaron Fleming
Aaron Fleming
Research Scientist, University of Utah
Подтвержден адрес электронной почты в домене chem.utah.edu - Главная страница
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Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair
AM Fleming, Y Ding, CJ Burrows
Proceedings of the National Academy of Sciences 114 (10), 2604-2609, 2017
3792017
Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution
V Khoddami, A Yerra, TL Mosbruger, AM Fleming, CJ Burrows, BR Cairns
Proceedings of the National Academy of Sciences 116 (14), 6784-6789, 2019
2342019
Sequencing the mouse genome for the oxidatively modified base 8-oxo-7, 8-dihydroguanine by OG-Seq
Y Ding, AM Fleming, CJ Burrows
Journal of the American Chemical Society 139 (7), 2569-2572, 2017
1792017
The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
J Zhou, AM Fleming, AM Averill, CJ Burrows, SS Wallace
Nucleic acids research 43 (8), 4039-4054, 2015
1702015
G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA
AM Fleming, CJ Burrows
Chemical research in toxicology 26 (4), 593-607, 2013
1592013
8-Oxo-7, 8-dihydroguanine, friend and foe: Epigenetic-like regulator versus initiator of mutagenesis
AM Fleming, CJ Burrows
DNA repair 56, 75-83, 2017
1482017
A role for the fifth G-track in G-quadruplex forming oncogene promoter sequences during oxidative stress: Do these “spare tires” have an evolved function?
AM Fleming, J Zhou, SS Wallace, CJ Burrows
ACS central science 1 (5), 226-233, 2015
1452015
Zika virus genomic RNA possesses conserved G-quadruplexes characteristic of the flaviviridae family
AM Fleming, Y Ding, A Alenko, CJ Burrows
ACS infectious diseases 2 (10), 674-681, 2016
1422016
Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context
J Zhou, M Liu, AM Fleming, CJ Burrows, SS Wallace
Journal of Biological Chemistry 288 (38), 27263-27272, 2013
1382013
Interplay of guanine oxidation and G-quadruplex folding in gene promoters
AM Fleming, CJ Burrows
Journal of the American Chemical Society 142 (3), 1115-1136, 2019
1332019
4n–1 Is a “Sweet Spot” in DNA i-Motif Folding of 2′-Deoxycytidine Homopolymers
AM Fleming, Y Ding, RA Rogers, J Zhu, J Zhu, AD Burton, CB Carlisle, ...
Journal of the American Chemical Society 139 (13), 4682-4689, 2017
1262017
Nanopore detection of 8-oxo-7, 8-dihydro-2′-deoxyguanosine in immobilized single-stranded DNA via adduct formation to the DNA damage site
AEP Schibel, N An, Q Jin, AM Fleming, CJ Burrows, HS White
Journal of the American Chemical Society 132 (51), 17992-17995, 2010
1262010
Formation and processing of DNA damage substrates for the hNEIL enzymes
AM Fleming, CJ Burrows
Free Radical Biology and Medicine 107, 35-52, 2017
1232017
Crown ether–electrolyte interactions permit nanopore detection of individual DNA abasic sites in single molecules
N An, AM Fleming, HS White, CJ Burrows
Proceedings of the National Academy of Sciences 109 (29), 11504-11509, 2012
1162012
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia
Y Sejersted, GA Hildrestrand, D Kunke, V Rolseth, SZ Krokeide, ...
Proceedings of the National Academy of Sciences 108 (46), 18802-18807, 2011
1132011
Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin
SZ Krokeide, JK Laerdahl, M Salah, L Luna, FH Cederkvist, AM Fleming, ...
DNA repair 12 (12), 1159-1164, 2013
1112013
8-Oxo-7, 8-dihydroguanine in the context of a gene promoter G-quadruplex is an on–off switch for transcription
AM Fleming, J Zhu, Y Ding, CJ Burrows
ACS chemical biology 12 (9), 2417-2426, 2017
1022017
On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics
AM Fleming, CJ Burrows
Chemical Society Reviews 49 (18), 6524-6528, 2020
1002020
Unzipping kinetics of duplex DNA containing oxidized lesions in an α-hemolysin nanopore
Q Jin, AM Fleming, CJ Burrows, HS White
Journal of the American Chemical Society 134 (26), 11006-11011, 2012
982012
Nanopore detection of 8-oxoguanine in the human telomere repeat sequence
N An, AM Fleming, HS White, CJ Burrows
ACS nano 9 (4), 4296-4307, 2015
972015
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