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Madison Doolittle
Madison Doolittle
Assistant Professor, UConn Health
Подтвержден адрес электронной почты в домене uchc.edu
Название
Процитировано
Процитировано
Год
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
D Saul, RL Kosinsky, EJ Atkinson, ML Doolittle, X Zhang, NK LeBrasseur, ...
Nature communications 13 (1), 4827, 2022
4302022
Targeting the gut microbiome to treat the osteoarthritis of obesity
EM Schott, CW Farnsworth, A Grier, JA Lillis, S Soniwala, GH Dadourian, ...
JCI insight 3 (8), 2018
2642018
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner
A Lagnado, J Leslie, MH Ruchaud‐Sparagano, S Victorelli, P Hirsova, ...
The EMBO journal 40 (9), e106048, 2021
1622021
Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity
A Chandra, AB Lagnado, JN Farr, M Doolittle, T Tchkonia, JL Kirkland, ...
Aging Cell 21 (5), e13602, 2022
762022
SenNet recommendations for detecting senescent cells in different tissues
V Suryadevara, AD Hudgins, A Rajesh, A Pappalardo, A Karpova, AK Dey, ...
Nature Reviews Molecular Cell Biology, 1-23, 2024
692024
Modulation of fracture healing by the transient accumulation of senescent cells
D Saul, DG Monroe, JL Rowsey, RL Kosinsky, SJ Vos, ML Doolittle, ...
Elife 10, e69958, 2021
542021
Local senolysis in aged mice only partially replicates the benefits of systemic senolysis
JN Farr, D Saul, ML Doolittle, J Kaur, JL Rowsey, SJ Vos, MN Froemming, ...
The Journal of clinical investigation 133 (8), 2023
452023
Osteocyte cellular senescence
JN Farr, J Kaur, ML Doolittle, S Khosla
Current osteoporosis reports 18, 559-567, 2020
342020
The role of senolytics in osteoporosis and other skeletal pathologies
ML Doolittle, DG Monroe, JN Farr, S Khosla
Mechanisms of ageing and development 199, 111565, 2021
302021
Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton
ML Doolittle, D Saul, J Kaur, JL Rowsey, SJ Vos, KD Pavelko, JN Farr, ...
Nature communications 14 (1), 4587, 2023
252023
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nat Commun 13: 4827
D Saul, RL Kosinsky, EJ Atkinson, ML Doolittle, X Zhang, NK LeB-rasseur, ...
242022
Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass
ML Doolittle, GM Calabrese, LD Mesner, DA Godfrey, RD Maynard, ...
PLoS genetics 16 (6), e1008805, 2020
212020
In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers
P Samakkarnthai, D Saul, L Zhang, Z Aversa, ML Doolittle, JG Sfeir, ...
Aging (Albany NY) 15 (9), 3331, 2023
192023
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nat Commun. 2022; 13: 4827
D Saul, RL Kosinsky, EJ Atkinson, ML Doolittle, X Zhang, NK LeBrasseur, ...
18
Identification of a suitable endogenous control miRNA in bone aging and senescence
J Kaur, D Saul, ML Doolittle, JL Rowsey, SJ Vos, JN Farr, S Khosla, ...
Gene 835, 146642, 2022
162022
Isolation and culture of neonatal mouse calvarial osteoblasts
ML Doolittle, CL Ackert-Bicknell, JH Jonason
Skeletal Development and Repair: Methods and Protocols, 425-436, 2021
132021
Skeletal effects of inducible ERα deletion in osteocytes in adult mice
ML Doolittle, D Saul, J Kaur, JL Rowsey, B Eckhardt, S Vos, S Grain, ...
Journal of Bone and Mineral Research 37 (9), 1750-1760, 2020
122020
Distinct secretomes in p16-and p21-positive senescent cells across tissues
D Saul, D Jurk, ML Doolittle, RL Kosinsky, DG Monroe, NK LeBrasseur, ...
bioRxiv, 2023
112023
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial
JN Farr, EJ Atkinson, SJ Achenbach, TL Volkman, AJ Tweed, SJ Vos, ...
Nature Medicine 30 (9), 2605-2612, 2024
82024
Senescent skeletal muscle fibroadipogenic progenitors recruit and promote M2 polarization of macrophages
X Zhang, YE Ng, LCS Chini, AA Heeren, TA White, H Li, H Huang, ...
Aging Cell 23 (3), e14069, 2024
82024
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Статьи 1–20