Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice YJ Xie, M Dougan, N Jailkhani, J Ingram, T Fang, L Kummer, N Momin, ... Proceedings of the National Academy of Sciences 116 (16), 7624-7631, 2019 | 282 | 2019 |
Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy N Momin, NK Mehta, NR Bennett, L Ma, JR Palmeri, MM Chinn, EA Lutz, ... Science translational medicine 11 (498), eaaw2614, 2019 | 204 | 2019 |
Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity Y Li, Z Su, W Zhao, X Zhang, N Momin, C Zhang, KD Wittrup, Y Dong, ... Nature cancer 1 (9), 882-893, 2020 | 191 | 2020 |
Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis FE Pulous, JC Cruz-Hernández, C Yang, Ζ Kaya, A Paccalet, ... Nature neuroscience 25 (5), 567-576, 2022 | 126 | 2022 |
Lack of CD8+ T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer BL Horton, DM Morgan, N Momin, M Zagorulya, E Torres-Mejia, ... Science immunology 6 (64), eabi8800, 2021 | 114 | 2021 |
Steric pressure between membrane-bound proteins opposes lipid phase separation CS Scheve, PA Gonzales, N Momin, JC Stachowiak Journal of the American Chemical Society 135 (4), 1185-1188, 2013 | 105 | 2013 |
Recruited macrophages elicit atrial fibrillation M Hulsmans, MJ Schloss, IH Lee, A Bapat, Y Iwamoto, C Vinegoni, ... Science 381 (6654), 231-239, 2023 | 97 | 2023 |
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer M Zagorulya, L Yim, DM Morgan, A Edwards, E Torres-Mejia, N Momin, ... Immunity 56 (2), 386-405. e10, 2023 | 83 | 2023 |
Improved antitumor efficacy of chimeric antigen receptor T cells that secrete single-domain antibody fragments YJ Xie, M Dougan, JR Ingram, N Pishesha, T Fang, N Momin, HL Ploegh Cancer immunology research 8 (4), 518-529, 2020 | 81 | 2020 |
Maximizing response to intratumoral immunotherapy in mice by tuning local retention N Momin, JR Palmeri, EA Lutz, N Jailkhani, H Mak, A Tabet, MM Chinn, ... Nature communications 13 (1), 109, 2022 | 67 | 2022 |
Pharmacokinetic tuning of protein–antigen fusions enhances the immunogenicity of T-cell vaccines NK Mehta, RV Pradhan, AP Soleimany, KD Moynihan, AM Rothschilds, ... Nature biomedical engineering 4 (6), 636-648, 2020 | 63 | 2020 |
Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses BH Kwan, EF Zhu, A Tzeng, HR Sugito, AA Eltahir, B Ma, MK Delaney, ... Journal of Experimental Medicine 214 (6), 1679-1690, 2017 | 54 | 2017 |
Designing lipids for selective partitioning into liquid ordered membrane domains N Momin, S Lee, AK Gadok, DJ Busch, GD Bachand, CC Hayden, ... Soft matter 11 (16), 3241-3250, 2015 | 45 | 2015 |
Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies EA Lutz, Y Agarwal, N Momin, SC Cowles, JR Palmeri, E Duong, V Hornet, ... Proceedings of the National Academy of Sciences 119 (36), e2205983119, 2022 | 27 | 2022 |
Combining the specific anti-MUC1 antibody TAB004 and lip-MSA-IL-2 limits pancreatic cancer progression in immune competent murine models of pancreatic ductal adenocarcinoma D Dréau, LJ Moore, M Wu, LD Roy, L Dillion, T Porter, R Puri, N Momin, ... Frontiers in oncology 9, 330, 2019 | 17 | 2019 |
Intratumoral nanobody–IL-2 fusions that bind the tumor extracellular matrix suppress solid tumor growth in mice EA Lutz, N Jailkhani, N Momin, Y Huang, A Sheen, BH Kang, KD Wittrup, ... PNAS nexus 1 (5), pgac244, 2022 | 16 | 2022 |
Overcoming lung cancer immunotherapy resistance by combining nontoxic variants of IL-12 and IL-2 BL Horton, A D D’Souza, M Zagorulya, CV McCreery, GC Abhiraman, ... JCI insight 8 (19), e172728, 2023 | 9 | 2023 |
Collagen-anchored interleukin-2 and interleukin-12 safely reprogram the tumor microenvironment in canine soft-tissue sarcomas JA Stinson, A Sheen, N Momin, J Hampel, R Bernstein, R Kamerer, ... Clinical Cancer Research 29 (11), 2110-2122, 2023 | 9 | 2023 |
Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice BH Kang, N Momin, KD Moynihan, M Silva, Y Li, DJ Irvine, KD Wittrup PloS One 16 (4), e0248903, 2021 | 7 | 2021 |
Co‐anchoring of engineered immunogen and immunostimulatory cytokines to alum promotes enhanced‐humoral immunity JYH Chang, Y Agarwal, KA Rodrigues, N Momin, K Ni, BJ Read, TJ Moyer, ... Advanced Therapeutics 5 (7), 2100235, 2022 | 6 | 2022 |