| Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans KC Nicolaou, JA Pfefferkorn, AJ Roecker, GQ Cao, S Barluenga, ... Journal of the American Chemical Society 122 (41), 9939-9953, 2000 | 943 | 2000 |
| Natural product-like combinatorial libraries based on privileged structures. 2. Construction of a 10 000-membered benzopyran library by directed split-and-pool chemistry using … KC Nicolaou, JA Pfefferkorn, HJ Mitchell, AJ Roecker, S Barluenga, ... Journal of the American Chemical Society 122 (41), 9954-9967, 2000 | 384 | 2000 |
| Natural product-like combinatorial libraries based on privileged structures. 3. The “libraries from libraries” principle for diversity enhancement of benzopyran libraries KC Nicolaou, JA Pfefferkorn, S Barluenga, HJ Mitchell, AJ Roecker, ... Journal of the American Chemical Society 122 (41), 9968-9976, 2000 | 284 | 2000 |
| Selenium‐based solid‐phase synthesis of benzopyrans I: applications to combinatorial synthesis of natural products KC Nicolaou, JA Pfefferkorn, GQ Cao Angewandte Chemie 112 (4), 750-755, 2000 | 217 | 2000 |
| Solid and solution phase synthesis and biological evaluation of combinatorial sarcodictyin libraries KC Nicolaou, N Winssinger, D Vourloumis, T Ohshima, S Kim, ... Journal of the American Chemical Society 120 (42), 10814-10826, 1998 | 211 | 1998 |
| ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials RA Calle, NB Amin, S Carvajal-Gonzalez, TT Ross, A Bergman, ... Nature medicine 27 (10), 1836-1848, 2021 | 163 | 2021 |
| A novel strategy for the solid-phase synthesis of substituted indolines KC Nicolaou, AJ Roecker, JA Pfefferkorn, GQ Cao Journal of the American Chemical Society 122 (12), 2966-2967, 2000 | 147 | 2000 |
| Total synthesis of sarcodictyins A and B KC Nicolaou, JY Xu, S Kim, J Pfefferkorn, T Ohshima, D Vourloumis, ... Journal of the American Chemical Society 120 (34), 8661-8673, 1998 | 147 | 1998 |
| Total synthesis of eleutherobin KC Nicolaou, F Van Delft, T Ohshima, D Vourloumis, J Xu, S Hosokawa, ... Angewandte Chemie International Edition in English 36 (22), 2520-2524, 1997 | 147 | 1997 |
| Synthesis of the tricyclic core of eleutherobin and sarcodictyins and total synthesis of sarcodictyin A KC Nicolaou, JY Xu, S Kim, T Ohshima, S Hosokawa, J Pfefferkorn Journal of the American Chemical Society 119 (46), 11353-11354, 1997 | 147 | 1997 |
| Total synthesis of eleutherobin and eleuthosides A and B KC Nicolaou, T Ohshima, S Hosokawa, FL Van Delft, D Vourloumis, JY Xu, ... Journal of the American Chemical Society 120 (34), 8674-8680, 1998 | 143 | 1998 |
| Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical … JA Pfefferkorn, A Guzman-Perez, J Litchfield, R Aiello, JL Treadway, ... Journal of medicinal chemistry 55 (3), 1318-1333, 2012 | 135 | 2012 |
| Combinatorial synthesis through disulfide exchange: Discovery of potent psammaplin A type antibacterial agents active against methicillin‐resistant Staphylococcus aureus (MRSA) KC Nicolaou, R Hughes, JA Pfefferkorn, S Barluenga, AJ Roecker Chemistry–A European Journal 7 (19), 4280-4295, 2001 | 133 | 2001 |
| Glycomimetic ligands for the human asialoglycoprotein receptor SK Mamidyala, S Dutta, BA Chrunyk, C Préville, H Wang, JM Withka, ... Journal of the American Chemical Society 134 (4), 1978-1981, 2012 | 130 | 2012 |
| Selenium‐Based Solid‐Phase Synthesis of Benzopyrans II: Applications to Combinatorial Synthesis of Medicinally Relevant Small Organic Molecules KC Nicolaou, GQ Cao, JA Pfefferkorn Angewandte Chemie 112 (4), 755-759, 2000 | 114 | 2000 |
| A facile method for the solution and solid-phase synthesis of substituted [3.3. 1] bicycles KC Nicolaou, JA Pfefferkorn, GQ Cao, S Kim, J Kessabi Organic Letters 1 (5), 807-810, 1999 | 113 | 1999 |
| Combinatorial synthesis of novel and potent inhibitors of NADH: ubiquinone oxidoreductase KC Nicolaou, JA Pfefferkorn, F Schuler, AJ Roecker, GQ Cao, JE Casida Chemistry & biology 7 (12), 979-992, 2000 | 109 | 2000 |
| Solution and Solid‐Phase Synthesis of Functionalized 3‐Arylbenzofurans by a Novel Cyclofragmentation–Release Pathway KC Nicolaou, SA Snyder, A Bigot, JA Pfefferkorn Angewandte Chemie 112 (6), 1135-1138, 2000 | 106 | 2000 |
| Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells JEC Jones, WP Esler, R Patel, A Lanba, NB Vera, JA Pfefferkorn, ... PloS one 12 (1), e0169566, 2017 | 102 | 2017 |
| Synthesis of the fully functionalized bicyclic core of garsubellin A KC Nicolaou, JA Pfefferkorn, S Kim, HX Wei Journal of the American Chemical Society 121 (19), 4724-4725, 1999 | 98 | 1999 |
