| Synthesis and applications of small molecule libraries LA Thompson, JA Ellman Chemical reviews 96 (1), 555-600, 1996 | 2129 | 1996 |
| Presenilin-1 and-2 are molecular targets for γ-secretase inhibitors D Seiffert, JD Bradley, CM Rominger, DH Rominger, F Yang, ... Journal of Biological Chemistry 275 (44), 34086-34091, 2000 | 434 | 2000 |
| Recent applications of polymer-supported reagents and scavengers in combinatorial, parallel, or multistep synthesis LA Thompson Current Opinion in Chemical Biology 4 (3), 324-337, 2000 | 291 | 2000 |
| Straightforward and general method for coupling alcohols to solid supports LA Thompson, JA Ellman Tetrahedron letters 35 (50), 9333-9336, 1994 | 272 | 1994 |
| Solid-phase synthesis of 1, 4-benzodiazepine-2, 5-diones. Library preparation and demonstration of synthesis generality CG Boojamra, KM Burow, LA Thompson, JA Ellman The Journal of Organic Chemistry 62 (5), 1240-1256, 1997 | 253 | 1997 |
| Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-α PH Carter, PA Scherle, JA Muckelbauer, ME Voss, RQ Liu, LA Thompson, ... Proceedings of the National Academy of Sciences 98 (21), 11879-11884, 2001 | 216 | 2001 |
| A counterselection for the tryptophan pathway in yeast: 5‐fluoroanthranilic acid resistance JH Toyn, PL Gunyuzlu, W Hunter White, LA Thompson, GF Hollis Yeast 16 (6), 553-560, 2000 | 141 | 2000 |
| Both 5-arylidene-2-thioxodihydropyrimidine-4, 6 (1H, 5H)-diones and 3-thioxo-2, 3-dihydro-1H-imidazo [1, 5-a] indol-1-ones are light-dependent tumor necrosis factor-α antagonists ME Voss, PH Carter, AJ Tebben, PA Scherle, GD Brown, LA Thompson, ... Bioorganic & medicinal chemistry letters 13 (3), 533-538, 2003 | 97 | 2003 |
| Solid-phase synthesis of diverse E-and F-series prostaglandins LA Thompson, FL Moore, YC Moon, JA Ellman The Journal of Organic Chemistry 63 (7), 2066-2067, 1998 | 95 | 1998 |
| Progress in the discovery of BACE inhibitors LA Thompson, JJ Bronson, FC Zusi Current pharmaceutical design 11 (26), 3383-3404, 2005 | 72 | 2005 |
| Parallel Synthesis of Prostaglandin E1 Analogues DR Dragoli, LA Thompson, J O'Brie, JA Ellman Journal of Combinatorial Chemistry 1 (6), 534-539, 1999 | 71 | 1999 |
| Identification and characterization of presenilin-independent Notch signaling BE Berechid, M Kitzmann, DR Foltz, AH Roach, D Seiffert, LA Thompson, ... Journal of Biological Chemistry 277 (10), 8154-8165, 2002 | 70 | 2002 |
| Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid-and solution-phase library synthesis SW Gerritz, W Zhai, S Shi, S Zhu, JH Toyn, JE Meredith Jr, LG Iben, ... Journal of Medicinal Chemistry 55 (21), 9208-9223, 2012 | 58 | 2012 |
| P-glycoprotein efflux and other factors limit brain amyloid β reduction by β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice JE Meredith Jr, LA Thompson, JH Toyn, L Marcin, DM Barten, ... The Journal of pharmacology and experimental therapeutics 326 (2), 502-513, 2008 | 53 | 2008 |
| Centrally delivered BACE1 inhibitor activates microglia, and reverses amyloid pathology and cognitive deficit in aged Tg2576 mice DR Thakker, S Sankaranarayanan, MR Weatherspoon, J Harrison, ... Journal of Neuroscience 35 (17), 6931-6936, 2015 | 49 | 2015 |
| The γ-secretase modulator, BMS-932481, modulates Aβ peptides in the plasma and cerebrospinal fluid of healthy volunteers HD Soares, M Gasior, JH Toyn, JS Wang, Q Hong, F Berisha, MT Furlong, ... The Journal of Pharmacology and Experimental Therapeutics 358 (1), 138-150, 2016 | 48 | 2016 |
| p38α regulates expression of DUX4 in a model of facioscapulohumeral muscular dystrophy LA Rojas, E Valentine, A Accorsi, J Maglio, N Shen, A Robertson, ... The Journal of Pharmacology and Experimental Therapeutics 374 (3), 489-498, 2020 | 44 | 2020 |
| Compounds for the reduction of beta-amyloid production KM Boy, JM Guernon, JE Macor, RE Olson, J Shi, LA Thompson III, YJ Wu, ... US Patent 8,637,525, 2014 | 40 | 2014 |
| Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain YJ Wu, J Guernon, J Shi, J Ditta, KJ Robbins, R Rajamani, A Easton, ... Journal of Medicinal Chemistry 60 (6), 2513-2525, 2017 | 39 | 2017 |
| Targeting the BACE1 active site flap leads to a potent inhibitor that elicits robust brain Aβ reduction in rodents YJ Wu, J Guernon, F Yang, L Snyder, J Shi, A Mcclure, R Rajamani, ... ACS Medicinal Chemistry Letters 7 (3), 271-276, 2016 | 35 | 2016 |
