| Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice TP Prakash, MJ Graham, J Yu, R Carty, A Low, A Chappell, K Schmidt, ... Nucleic acids research 42 (13), 8796-8807, 2014 | 644 | 2014 |
| 6-modified bicyclic nucleic acid analogs EES Punit P. Seth US Patent 7,741,457, 2010 | 520* | 2010 |
| 6-modified bicyclic nucleic acid analogs PP Seth, EE Swayze US Patent 7,399,845, 2008 | 520 | 2008 |
| The medicinal chemistry of therapeutic oligonucleotides WB Wan, PP Seth Journal of medicinal chemistry 59 (21), 9645-9667, 2016 | 437 | 2016 |
| 5′-modified bicyclic nucleic acid analogs PP Seth, EE Swayze, B Bhat US Patent 7,547,684, 2009 | 411 | 2009 |
| Short antisense oligonucleotides with novel 2′− 4′ conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals PP Seth, A Siwkowski, CR Allerson, G Vasquez, S Lee, TP Prakash, ... Journal of medicinal chemistry 52 (1), 10-13, 2009 | 294 | 2009 |
| Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index W Shen, CL De Hoyos, MT Migawa, TA Vickers, H Sun, A Low, TA Bell III, ... Nature biotechnology 37 (6), 640-650, 2019 | 287 | 2019 |
| Single-stranded siRNAs activate RNAi in animals WF Lima, TP Prakash, HM Murray, GA Kinberger, W Li, AE Chappell, ... Cell 150 (5), 883-894, 2012 | 282 | 2012 |
| Compounds and methods for synthesis of bicyclic nucleic acid analogs B Bhat, J Xia, PP Seth, G Vasquez, MT Migawa, C Allerson, TP Prakash, ... US Patent 7,569,686, 2009 | 263 | 2009 |
| Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′O-Methoxyethyl and 2′,4′-Constrained 2′O-Ethyl Nucleic Acid Analogues PP Seth, G Vasquez, CA Allerson, A Berdeja, H Gaus, GA Kinberger, ... The Journal of organic chemistry 75 (5), 1569-1581, 2010 | 262 | 2010 |
| Bis-modified bicyclic nucleic acid analogs PP Seth, EE Swayze US Patent 7,666,854, 2010 | 236 | 2010 |
| SAR by MS: discovery of a new class of RNA-binding small molecules for the hepatitis C virus: internal ribosome entry site IIA subdomain PP Seth, A Miyaji, EA Jefferson, KA Sannes-Lowery, SA Osgood, ... Journal of medicinal chemistry 48 (23), 7099-7102, 2005 | 210 | 2005 |
| Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts SA Burel, CE Hart, P Cauntay, J Hsiao, T Machemer, M Katz, A Watt, ... Nucleic acids research 44 (5), 2093-2109, 2016 | 193 | 2016 |
| Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS ME Østergaard, AL Southwell, H Kordasiewicz, AT Watt, NH Skotte, ... Nucleic acids research 41 (21), 9634-9650, 2013 | 187 | 2013 |
| Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver CM Miller, AJ Donner, EE Blank, AW Egger, BM Kellar, ME Østergaard, ... Nucleic acids research 44 (6), 2782-2794, 2016 | 181 | 2016 |
| Targeted delivery of antisense oligonucleotides to pancreatic β-cells C Ämmälä, WJ Drury III, L Knerr, I Ahlstedt, P Stillemark-Billton, ... Science advances 4 (10), eaat3386, 2018 | 180 | 2018 |
| Carbocyclic alpha-L-bicyclic nucleic acid analogs PP Seth, EE Swayze US Patent 8,546,556, 2013 | 170 | 2013 |
| Substituted alpha-L-bicyclic nucleosides PP Seth, EE Swayze US Patent 8,501,805, 2013 | 170 | 2013 |
| In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides AL Southwell, NH Skotte, HB Kordasiewicz, ME Østergaard, AT Watt, ... Molecular Therapy 22 (12), 2093-2106, 2014 | 168 | 2014 |
| Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients NH Skotte, AL Southwell, ME Østergaard, JB Carroll, SC Warby, CN Doty, ... PloS one 9 (9), e107434, 2014 | 164 | 2014 |