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Alex S. Holehouse
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A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins
J Wang, JM Choi, AS Holehouse, HO Lee, X Zhang, M Jahnel, ...
Cell 174 (3), 688-699. e16, 2018
17572018
Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
EW Martin*, AS Holehouse*, I Peran*, M Farag, JJ Incicco, A Bremer, ...
Science 367 (6478), 694-699, 2020
8612020
Sequence determinants of intracellular phase separation by complex coacervation of a disordered protein
CW Pak, M Kosno, AS Holehouse, SB Padrick, A Mittal, R Ali, AA Yunus, ...
Molecular Cell 63 (1), 72-85, 2016
7682016
RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation
J Guillén-Boixet*, A Kopach*, AS Holehouse, S Wittmann, M Jahnel, ...
Cell 181 (2), 346-361. e17, 2020
7152020
Physical principles underlying the complex biology of intracellular phase transitions
JM Choi-✝, AS Holehouse-✝, RV Pappu-✝
Annual Review of Biophysics 49, 107-133, 2020
7132020
Phase separation of a yeast prion protein promotes cellular fitness
TM Franzmann, M Jahnel, A Pozniakovsky, J Mahamid, AS Holehouse, ...
Science 359 (6371), eaao5654, 2018
6812018
Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins
TS Harmon, AS Holehouse, MK Rosen, RV Pappu
elife 6, e30294, 2017
6312017
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
J Cubuk, JJ Alston, J Jeremías Incicco, S Singh, MD Stuchell-Brereton, ...
Nature Communications 12 (1), 1–17, 2021
5612021
Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles
MT Wei*, S Elbaum-Garfinkle*, AS Holehouse*, CCH Chen, M Feric, ...
Nature Chemistry 9, 1118–1125, 2017
5392017
CIDER: resources to analyze sequence-ensemble relationships of intrinsically disordered proteins
AS Holehouse, RK Das, JN Ahad, MOG Richardson, RV Pappu
Biophysical journal 112 (1), 16-21, 2017
5122017
Spontaneous driving forces give rise to protein− RNA condensates with coexisting phases and complex material properties
S Boeynaems, AS Holehouse, V Weinhardt, D Kovacs, J Van Lindt, ...
Proceedings of the National Academy of Sciences 116 (16), 7889-7898, 2019
4372019
Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution
J Fei, M Jadaliha, TS Harmon, ITS Li, B Hua, Q Hao, AS Holehouse, ...
Journal of cell science 130 (24), 4180-4192, 2017
2652017
Sequence determinants of the conformational properties of an intrinsically disordered protein prior to and upon multisite phosphorylation
EW Martin*, AS Holehouse*, CR Grace, A Hughes, RV Pappu, T Mittag
Journal of the American Chemical Society 138 (47), 15323-15335, 2016
2652016
Nucleo-cytoplasmic partitioning of ARF proteins controls auxin responses in Arabidopsis thaliana
SK Powers, AS Holehouse, DA Korasick, KH Schreiber, NM Clark, H Jing, ...
Molecular cell 76 (1), 177-190. e5, 2019
2442019
The molecular basis for cellular function of intrinsically disordered protein regions
AS Holehouse, BB Kragelund
Nature Reviews Molecular Cell Biology 25 (3), 187-211, 2024
2342024
Functional implications of intracellular phase transitions
AS Holehouse, RV Pappu
Biochemistry 57 (17), 2415-2423, 2018
2312018
Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof.
EW Martin, AS Holehouse
Emerging topics in life sciences 4 (3), 307-329, 2020
2172020
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation
DW Sanders, CC Jumper, PJ Ackerman, D Bracha, A Donlic, H Kim, ...
elife 10, e65962, 2021
2112021
Phase Separation of Intrinsically Disordered Proteins
AE Posey*, AS Holehouse*, RV Pappu
Methods in Enzymology, 2018
1892018
Arginine-enriched mixed-charge domains provide cohesion for nuclear speckle condensation
JA Greig, TA Nguyen, M Lee, AS Holehouse, AE Posey, RV Pappu, ...
Molecular cell 77 (6), 1237-1250. e4, 2020
1842020
Systém momentálne nemôže vykonať operáciu. Skúste to neskôr.
Články 1–20