| Optogenetic protein clustering and signaling activation in mammalian cells LJ Bugaj, AT Choksi, CK Mesuda, RS Kane, DV Schaffer Nature methods 10 (3), 249-252, 2013 | 518 | 2013 |
| Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats JH Kim, LJ Bugaj, YJ Oh, TJ Bivalacqua, S Ryoo, KG Soucy, L Santhanam, ... Journal of applied physiology 107 (4), 1249-1257, 2009 | 296 | 2009 |
| Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway LJ Bugaj, AJ Sabnis, A Mitchell, JE Garbarino, JE Toettcher, TG Bivona, ... Science 361 (6405), eaao3048, 2018 | 160 | 2018 |
| Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal H Yousef, MJ Conboy, A Morgenthaler, C Schlesinger, L Bugaj, P Paliwal, ... Oncotarget 6 (14), 11959, 2015 | 129 | 2015 |
| Age-associated increase in BMP signaling inhibits hippocampal neurogenesis H Yousef, A Morgenthaler, C Schlesinger, L Bugaj, IM Conboy, ... Stem cells 33 (5), 1577-1588, 2015 | 119 | 2015 |
| High-throughput multicolor optogenetics in microwell plates LJ Bugaj, WA Lim Nature protocols 14 (7), 2205-2228, 2019 | 116 | 2019 |
| Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering LJ Bugaj, DP Spelke, CK Mesuda, M Varedi, RS Kane, DV Schaffer Nature communications 6 (1), 6898, 2015 | 112 | 2015 |
| Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism J Steppan, S Ryoo, KH Schuleri, C Gregg, RK Hasan, AR White, LJ Bugaj, ... Proceedings of the National Academy of Sciences 103 (12), 4759-4764, 2006 | 106 | 2006 |
| Vertebrate cells differentially interpret ciliary and extraciliary cAMP ME Truong, S Bilekova, SP Choksi, W Li, LJ Bugaj, K Xu, JF Reiter Cell 184 (11), 2911-2926. e18, 2021 | 96 | 2021 |
| Modular engineering of cellular signaling proteins and networks RM Gordley, LJ Bugaj, WA Lim Current opinion in structural biology 39, 106-114, 2016 | 79 | 2016 |
| Interrogating cellular perception and decision making with optogenetic tools LJ Bugaj, GP O’Donoghue, WA Lim The Journal of cell biology 216 (1), 25, 2017 | 55 | 2017 |
| Optogenetic control reveals differential promoter interpretation of transcription factor nuclear translocation dynamics SY Chen, LC Osimiri, M Chevalier, LJ Bugaj, TH Nguyen, RA Greenstein, ... Cell systems 11 (4), 336-353. e24, 2020 | 54 | 2020 |
| T cells selectively filter oscillatory signals on the minutes timescale GP O’Donoghue, LJ Bugaj, W Anderson, KG Daniels, DJ Rawlings, ... Proceedings of the National Academy of Sciences 118 (9), e2019285118, 2021 | 47 | 2021 |
| β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells AB Rosenbloom, M Tarczyński, N Lam, RS Kane, LJ Bugaj, DV Schaffer Proceedings of the National Academy of Sciences 117 (46), 28828-28837, 2020 | 46 | 2020 |
| Light-inducible activation of target mRNA translation in mammalian cells J Cao, M Arha, C Sudrik, LJ Bugaj, DV Schaffer, RS Kane Chemical Communications 49 (75), 8338-8340, 2013 | 41 | 2013 |
| Single‐component optogenetic tools for inducible RhoA GTPase signaling EE Berlew, IA Kuznetsov, K Yamada, LJ Bugaj, JD Boerckel, BY Chow Advanced Biology 5 (9), 2100810, 2021 | 31 | 2021 |
| Temperature-responsive optogenetic probes of cell signaling W Benman, EE Berlew, H Deng, C Parker, IA Kuznetsov, B Lim, ... Nature chemical biology 18 (2), 152-160, 2022 | 30 | 2022 |
| Optogenetic Rac1 engineered from membrane lipid-binding RGS-LOV for inducible lamellipodia formation EE Berlew, IA Kuznetsov, K Yamada, LJ Bugaj, BY Chow Photochemical & Photobiological Sciences 19, 353-361, 2020 | 27 | 2020 |
| Bringing next-generation therapeutics to the clinic through synthetic biology LJ Bugaj, DV Schaffer Current Opinion in Chemical Biology 16 (3-4), 355-361, 2012 | 19 | 2012 |
| Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway AR White, S Ryoo, L Bugaj, DO Attarzadeh, S Thiyagarajan, K Chen, ... European journal of applied physiology 110, 395-404, 2010 | 18 | 2010 |
David SchafferProfessor of Chemical and Biomolecular Engineering, Bioengineering, and Neuroscience, UC BerkeleyOverená e-mailová adresa na: berkeley.edu
