| Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser Y Kang, XE Zhou, X Gao, Y He, W Liu, A Ishchenko, A Barty, TA White, ... Nature 523 (7562), 561, 2015 | 869 | 2015 |
| Identification of phosphorylation codes for arrestin recruitment by G protein-coupled receptors XE Zhou, Y He, PW de Waal, X Gao, Y Kang, N Van Eps, Y Yin, K Pal, ... Cell 170 (3), 457-469. e13, 2017 | 444 | 2017 |
| Cryo-EM structure of human rhodopsin bound to an inhibitory G protein Y Kang, O Kuybeda, PW de Waal, S Mukherjee, N Van Eps, P Dutka, ... Nature, 2018 | 281 | 2018 |
| Structure and dynamics of the active human parathyroid hormone receptor-1 LH Zhao, S Ma, I Sutkeviciute, DD Shen, XE Zhou, PW de Waal, CY Li, ... Science 364 (6436), 148-153, 2019 | 218 | 2019 |
| A complex structure of arrestin-2 bound to a G protein-coupled receptor W Yin, Z Li, M Jin, YL Yin, PW De Waal, K Pal, Y Yin, X Gao, Y He, J Gao, ... Cell research 29 (12), 971-983, 2019 | 208 | 2019 |
| Structural basis of AMPK regulation by adenine nucleotides and glycogen X Li, L Wang, XE Zhou, J Ke, PW de Waal, X Gu, MHE Tan, D Wang, ... Cell research 25 (1), 50, 2015 | 199 | 2015 |
| Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3 LH Zhao, XE Zhou, W Yi, Z Wu, Y Liu, Y Kang, L Hou, PW de Waal, S Li, ... Cell research 25 (11), 1219, 2015 | 189 | 2015 |
| Crystal structure of the Frizzled 4 receptor in a ligand-free state. S Yang, Y Wu, TH Xu, PW de Waal, Y He, M Pu, Y Chen, ZJ DeBruine, ... Nature, 2018 | 115 | 2018 |
| Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling Y Zhuang, H Liu, X Edward Zhou, R Kumar Verma, PW de Waal, W Jang, ... Nature communications 11 (1), 885, 2020 | 107 | 2020 |
| Crystal structure of the human 5-HT 1B serotonin receptor bound to an inverse agonist W Yin, XE Zhou, D Yang, PW de Waal, M Wang, A Dai, X Cai, CY Huang, ... Cell discovery 4 (1), 12, 2018 | 85 | 2018 |
| Molecular basis for hormone recognition and activation of corticotropin-releasing factor receptors S Ma, Q Shen, LH Zhao, C Mao, XE Zhou, DD Shen, PW de Waal, P Bi, ... Molecular cell 77 (3), 669-680. e4, 2020 | 79 | 2020 |
| The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer P Liu, M Jia, XE Zhou, PW de Waal, BM Dickson, B Liu, L Hou, Y Yin, ... Acta Pharmacologica Sinica, 2016 | 67 | 2016 |
| Structural mechanism of a drug-binding process involving a large conformational change of the protein target P Ayaz, A Lyczek, YT Paung, VR Mingione, RE Iacob, PW de Waal, ... Nature communications 14 (1), 1885, 2023 | 66 | 2023 |
| X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex XE Zhou, X Gao, A Barty, Y Kang, Y He, W Liu, A Ishchenko, TA White, ... Scientific data 3 (1), 1-13, 2016 | 65 | 2016 |
| Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing X Gu, Y Yan, SJ Novick, A Kovach, D Goswami, J Ke, MHE Tan, L Wang, ... Journal of Biological Chemistry 292 (30), 12653-12666, 2017 | 63 | 2017 |
| Molecular mechanisms of fentanyl mediated β-arrestin biased signaling PW de Waal, J Shi, E You, X Wang, K Melcher, Y Jiang, HE Xu, ... PLOS Computational Biology 16 (4), e1007394, 2020 | 55 | 2020 |
| Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and … LK Golani, A Wallace-Povirk, SM Deis, J Wong, J Ke, X Gu, S Raghavan, ... Journal of medicinal chemistry 59 (17), 7856-7876, 2016 | 45 | 2016 |
| Molecular dynamics of CYP2D6 polymorphisms in the absence and presence of a mechanism-based inactivator reveals changes in local flexibility and dominant substrate access channels PW de Waal, KF Sunden, LL Furge PLoS One 9 (10), e108607, 2014 | 27 | 2014 |
| Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class BG protein-coupled receptors Y Yin, PW de Waal, Y He, LH Zhao, D Yang, X Cai, Y Jiang, K Melcher, ... Journal of Biological Chemistry, jbc. M117. 782987, 2017 | 26 | 2017 |
| Development of “plug and play” fiducial marks for structural studies of GPCR signaling complexes by single-particle cryo-EM P Dutka, S Mukherjee, X Gao, Y Kang, PW de Waal, L Wang, Y Zhuang, ... Structure 27 (12), 1862-1874. e7, 2019 | 23 | 2019 |
Karsten MelcherVan Andel InstituteOverená e-mailová adresa na: vai.org