| Diversity-oriented synthesis yields novel multistage antimalarial inhibitors N Kato, E Comer, T Sakata-Kato, A Sharma, M Sharma, M Maetani, ... Nature 538 (7625), 344-349, 2016 | 265 | 2016 |
| UCT943, a next generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria C Brunschwig, N Lawrence, D Taylor, E Abay, M Njoroge, GS Basarab, ... Antimicrobial Agents and Chemotherapy, AAC. 00012-18, 2018 | 72 | 2018 |
| Design and structural characterization of potent and selective inhibitors of phosphatidylinositol 4 kinase IIIβ FU Rutaganira, ML Fowler, JA McPhail, MA Gelman, K Nguyen, A Xiong, ... Journal of medicinal chemistry 59 (5), 1830-1839, 2016 | 64 | 2016 |
| (S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable … D Rageot, T Bohnacker, E Keles, JA McPhail, RM Hoffmann, A Melone, ... Journal of medicinal chemistry 62 (13), 6241-6261, 2019 | 56 | 2019 |
| Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11 ML Fowler, JA McPhail, ML Jenkins, GR Masson, FU Rutaganira, ... Protein Science 25 (4), 826-839, 2016 | 50 | 2016 |
| The molecular basis of Aichi virus 3A protein activation of phosphatidylinositol 4 kinase IIIβ, PI4KB, through ACBD3 JA McPhail, EH Ottosen, ML Jenkins, JE Burke Structure 25 (1), 121-131, 2017 | 49 | 2017 |
| Covalent proximity scanning of a distal cysteine to target PI3Kα C Borsari, E Keles, JA McPhail, A Schaefer, R Sriramaratnam, W Goch, ... Journal of the American Chemical Society 144 (14), 6326-6342, 2022 | 47 | 2022 |
| Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 ML Jenkins, JP Margaria, JTB Stariha, RM Hoffmann, JA McPhail, ... Nature Communications 9 (1), 3772, 2018 | 42 | 2018 |
| Type III phosphatidylinositol 4 kinases: structure, function, regulation, signalling and involvement in disease GL Dornan, JA McPhail, JE Burke Biochemical Society transactions 44 (1), 260-266, 2016 | 41 | 2016 |
| Characterization of the c10orf76‐PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication JA McPhail, H Lyoo, JG Pemberton, RM Hoffmann, W van Elst, ... EMBO reports 21 (2), e48441, 2020 | 39 | 2020 |
| Molecular mechanisms of PI4K regulation and their involvement in viral replication. JA McPhail, JE Burke Traffic (Copenhagen, Denmark), 2022 | 34 | 2022 |
| Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors S Fienberg, CJ Eyermann, LB Arendse, GS Basarab, JA McPhail, ... ACS Infectious Diseases 6 (11), 3048-3063, 2020 | 27 | 2020 |
| Drugging the phosphoinositide 3-kinase (PI3K) and phosphatidylinositol 4-kinase (PI4K) family of enzymes for treatment of cancer, immune disorders, and viral/parasitic infections JA McPhail, JE Burke Druggable Lipid Signaling Pathways, 203-222, 2020 | 23 | 2020 |
| Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates RS Saleeb, C Leighton, JE Lee, J O’Shaughnessy, K Jeacock, ... Science Advances 9 (46), eadi7359, 2023 | 2 | 2023 |
| Microglia internalize tau monomers and fibrils using distinct receptors but similar mechanisms KF Falkon, L Danford, E Gutierrez Kuri, P Esquinca‐Moreno, ... Alzheimer's & Dementia, 2024 | 1 | 2024 |
| Defining how viruses manipulate lipid phosphoinositides through activation of PI4P kinases to mediate viral replication JE Burke, JA McPhail, M Rathinaswamy, ML Jenkins The FASEB Journal 34 (S1), 1-1, 2020 | 1 | 2020 |
| Characterization of the Golgi c10orf76-PI4KB complex, and its necessity for Golgi PI4P levels and enterovirus replication JA McPhail, HR Lyoo, JG Pemberton, RM Hoffmann, W van Elst, J Strating, ... bioRxiv, 634592, 2019 | 1 | 2019 |
| Driving Tau Pathogenicity Seeding‐How Fibril Structure and Post‐Translational Modifications Alter Seeding Capacity A Kasen, L Breton, L Meyerdirk, S Lövestam, J McPhail, A Louwrier, ... Alzheimer's & Dementia 20, e094584, 2024 | | 2024 |
| Development of optimized chemical probes targeting PI3Ka to deconvolute the role of class I PI3Ks isoforms in insulin signaling M De Pascale, C Borsari, E Keles, J McPhail, A Schäfer, R Sriramaratnam, ... Cancer Research 81 (13_Supplement), 291-291, 2021 | | 2021 |
| Volume scanning, a rational approach to covalent PI3Kα inhibitors C Borsari, E Keles, J McPhail, A Schäfer, R Sriramaratnam, M De Pascale, ... Cancer Research 81 (13_Supplement), 1377-1377, 2021 | | 2021 |
