TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A AL Brown, OG Wilkins, MJ Keuss, SE Hill, M Zanovello, WC Lee, ... Nature 603 (7899), 131-137, 2022 | 326 | 2022 |
Highly disordered histone H1− DNA model complexes and their condensates AL Turner, M Watson, OG Wilkins, L Cato, A Travers, JO Thomas, K Stott Proceedings of the National Academy of Sciences 115 (47), 11964-11969, 2018 | 204 | 2018 |
Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD S Seddighi, YA Qi, AL Brown, OG Wilkins, C Bereda, C Belair, YJ Zhang, ... Science translational medicine 16 (734), eadg7162, 2024 | 82 | 2024 |
FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation N Birsa, AM Ule, MG Garone, B Tsang, F Mattedi, PA Chong, J Humphrey, ... Science Advances 7 (30), eabf8660, 2021 | 57 | 2021 |
MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration R Simone, F Javad, W Emmett, OG Wilkins, FL Almeida, ... Nature 594 (7861), 117-123, 2021 | 50 | 2021 |
Ultraplex: A rapid, flexible, all-in-one fastq demultiplexer OG Wilkins, C Capitanchik, NM Luscombe, J Ule Wellcome Open Research 6, 2021 | 28 | 2021 |
Consortium AL Brown, OG Wilkins, MJ Keuss, SE Hill, M Zanovello, WC Lee, ... NA, Newcombe, J., Gustavsson, EK, Seddighi, S.,… Maggin, D, 2022 | 23 | 2022 |
An improved iCLIP protocol FCY Lee, AM Chakrabarti, H Hänel, E Monzón-Casanova, M Hallegger, ... BioRxiv, 2021.08. 27.457890, 2021 | 23 | 2021 |
Identifying ribosome heterogeneity using ribosome profiling F Alkan, OG Wilkins, S Hernández-Pérez, S Ramalho, J Silva, J Ule, ... Nucleic acids research 50 (16), e95-e95, 2022 | 18 | 2022 |
Creation of de novo cryptic splicing for ALS and FTD precision medicine OG Wilkins, MZYJ Chien, JJ Wlaschin, S Barattucci, P Harley, F Mattedi, ... Science 386 (6717), 61-69, 2024 | 7 | 2024 |
TDP-43 loss induces extensive cryptic polyadenylation in ALS/FTD S Bryce-Smith, AL Brown, PR Mehta, F Mattedi, A Mikheenko, S Barattucci, ... BioRxiv, 2024 | 7 | 2024 |
Loss of TDP-43 induces synaptic dysfunction that is rescued by UNC13A splice-switching ASOs MJ Keuss, P Harley, E Ryadnov, RE Jackson, M Zanovello, OG Wilkins, ... BioRxiv, 2024 | 6 | 2024 |
Ribocutter: Cas9-mediated rRNA depletion from multiplexed Ribo-seq libraries OG Wilkins, J Ule bioRxiv, 2021.07. 14.451473, 2021 | 6 | 2021 |
From computational models of the splicing code to regulatory mechanisms and therapeutic implications C Capitanchik, OG Wilkins, N Wagner, J Gagneur, J Ule Nature Reviews Genetics, 1-20, 2024 | 2 | 2024 |
Flow: a web platform and open database to analyse, store, curate and share bioinformatics data at scale C Capitanchik, S Ireland, A Harston, C Cheshire, DM Jones, FCY Lee, ... bioRxiv, 2023.08. 22.544179, 2023 | 2 | 2023 |
Mutual homeostasis of charged proteins R Faraway, NC Heaven, H Digby, OG Wilkins, AM Chakrabarti, IA Iosub, ... bioRxiv, 2023.08. 21.554177, 2023 | 1 | 2023 |
THERAPEUTICS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS P Fratta, AL Brown, O Wilkins, M Keuss, M Ward, S Hill US Patent App. 18/266,210, 2024 | | 2024 |
Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A AL Brown, OG Wilkins, MJ Keuss, SE Hill, M Zanovello, WC Lee, ... Nature, 1-1, 2024 | | 2024 |
Riboseq-flow: A streamlined, reliable pipeline for ribosome profiling data analysis and quality control IA Iosub, OG Wilkins, J Ule Wellcome Open Research 9, 2024 | | 2024 |
Identifying and rectifying aberrant RNA metabolism in amyotrophic lateral sclerosis OG Wilkins UCL (University College London), 2023 | | 2023 |