| Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate A Salmeen, JN Andersen, MP Myers, TC Meng, JA Hinks, NK Tonks, ... Nature 423 (6941), 769-773, 2003 | 1156 | 2003 |
| Structural and evolutionary relationships among protein tyrosine phosphatase domains JN Andersen, OH Mortensen, GH Peters, PG Drake, LF Iversen, OH Olsen, ... Molecular and cellular biology, 2001 | 925 | 2001 |
| Cancer genomics: from discovery science to personalized medicine L Chin, JN Andersen, PA Futreal Nature medicine 17 (3), 297-303, 2011 | 762 | 2011 |
| TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B MP Myers, JN Andersen, A Cheng, ML Tremblay, CM Horvath, ... Journal of Biological Chemistry 276 (51), 47771-47774, 2001 | 647 | 2001 |
| Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B A Salmeen, JN Andersen, MP Myers, NK Tonks, D Barford Molecular cell 6 (6), 1401-1412, 2000 | 567 | 2000 |
| A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage JN Andersen, PG Jansen, SM Echwald, OH Mortensen, T Fukada, ... The FASEB journal 18 (1), 8-30, 2004 | 441 | 2004 |
| The SMARCA2/4 ATPase domain surpasses the bromodomain as a drug target in SWI/SNF-mutant cancers: insights from cDNA rescue and PFI-3 inhibitor studies B Vangamudi, TA Paul, PK Shah, M Kost-Alimova, L Nottebaum, X Shi, ... Cancer research 75 (18), 3865-3878, 2015 | 266 | 2015 |
| Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors JN Andersen, S Sathyanarayanan, A Di Bacco, A Chi, T Zhang, AH Chen, ... Science translational medicine 2 (43), 43ra55-43ra55, 2010 | 226 | 2010 |
| A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors A Loboda, M Nebozhyn, R Klinghoffer, J Frazier, M Chastain, W Arthur, ... BMC medical genomics 3, 1-11, 2010 | 187 | 2010 |
| Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity A Haque, JN Andersen, A Salmeen, D Barford, NK Tonks Cell 147 (1), 185-198, 2011 | 172 | 2011 |
| Structure-guided design of IACS-9571, a selective high-affinity dual TRIM24-BRPF1 bromodomain inhibitor WS Palmer, G Poncet-Montange, G Liu, A Petrocchi, N Reyna, ... Journal of medicinal chemistry 59 (4), 1440-1454, 2016 | 169 | 2016 |
| Cellular effects of small molecule PTP1B inhibitors on insulin signaling L Xie, SY Lee, JN Andersen, S Waters, K Shen, XL Guo, NPH Moller, ... Biochemistry 42 (44), 12792-12804, 2003 | 163 | 2003 |
| Sensitive multiplexed analysis of kinase activities and activity-based kinase identification K Kubota, R Anjum, Y Yu, RC Kunz, JN Andersen, M Kraus, H Keilhack, ... Nature biotechnology 27 (10), 933-940, 2009 | 122 | 2009 |
| Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor K Nagashima, SD Shumway, S Sathyanarayanan, AH Chen, B Dolinski, ... Journal of Biological Chemistry 286 (8), 6433-6448, 2011 | 83 | 2011 |
| Comparative study of protein tyrosine phosphatase-ɛ isoforms: membrane localization confers specificity in cellular signalling JN ANDERSEN, A Elson, R LAMMERS, J RØMER, JT CLAUSEN, ... Biochemical Journal 354 (3), 581-590, 2001 | 69 | 2001 |
| TRIM28 multi-domain protein regulates cancer stem cell population in breast tumor development P Czerwińska, PK Shah, K Tomczak, M Klimczak, S Mazurek, B Sozańska, ... Oncotarget 8 (1), 863, 2016 | 64 | 2016 |
| TRIM24 links glucose metabolism with transformation of human mammary epithelial cells TN Pathiraja, KN Thakkar, S Jiang, S Stratton, Z Liu, M Gagea, X Shi, ... Oncogene 34 (22), 2836-2845, 2015 | 60 | 2015 |
| Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening EV Bobkova, MJ Weber, Z Xu, YL Zhang, J Jung, P Blume-Jensen, ... Journal of Biological Chemistry 285 (24), 18838-18846, 2010 | 59 | 2010 |
| Molecular dynamics simulations of protein-tyrosine phosphatase 1B. II. Substrate-enzyme interactions and dynamics GH Peters, TM Frimurer, JN Andersen, OH Olsen Biophysical Journal 78 (5), 2191-2200, 2000 | 59 | 2000 |
| Molecular dynamics simulations of protein-tyrosine phosphatase 1B. I. Ligand-induced changes in the protein motions GH Peters, TM Frimurer, JN Andersen, OH Olsen Biophysical Journal 77 (1), 505-515, 1999 | 57 | 1999 |
David BarfordMRC Laboratory of Molecular BiologyOverená e-mailová adresa na: mrc-lmb.cam.ac.uk
